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Antidotes for Acetaminophen Overdose

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Questions and Answers

What is the function of N-acetylcysteine in acetaminophen overdose?

Increasing liver injury

Enhancing the activity of cytochrome P450

Detoxifying the toxic metabolite NAPQI (correct)

Promoting the formation of harmful metabolites

What is the role of Flumazenil in benzodiazepine overdose?

Reverting the effects of intoxication (correct)

Inducing acute withdrawal syndrome

Acting as a benzodiazepine receptor agonist

Precipitating cell injury

Why is careful monitoring necessary when administering Naloxone?

To prevent acute withdrawal syndrome

As the naloxone effects wear off (correct)

To prolong the naloxone effects

To induce renarcotisation

What can happen if the detoxification pathway for NAPQI becomes saturated?

Increased liver injury Signup and view all the answers

What is the impact of acetaminophen overdose on liver cells?

Cell injury and death Signup and view all the answers

In what scenario is Naloxone used as a treatment?

Opiate overdose Signup and view all the answers

What is the mechanism of action of naloxone in opiate overdose?

Competitive antagonist at opioid receptors Signup and view all the answers

Why is dual consultation between a psychiatrist and pain management specialist essential for pain management in cases of opiate ingestion with suicidal intent?

To manage psychiatric comorbidity Signup and view all the answers

What is the primary function of flumazenil in managing benzodiazepine overdose?

Competitively inhibiting benzodiazepine activity Signup and view all the answers

When should high-risk patients with paracetamol overdose be treated with N-acetylcysteine?

At a paracetamol concentration above the treatment line Signup and view all the answers

What effect can discontinuing naloxone therapy have on chronic pain patients who are not using opiates recreationally?

Increase in pain Signup and view all the answers

Which route of administration is suitable for giving flumazenil in benzodiazepine overdose?

Intravenous or infusion routes Signup and view all the answers

Why is it important to assess paracetamol concentration 4 hours after overdose when considering N-acetylcysteine treatment?

To evaluate risk of hepatotoxicity Signup and view all the answers

What effect does N-acetylcysteine have on hepatic glutathione stores in cases of paracetamol overdose?

Replace exhausted stores Signup and view all the answers

Which characteristic differentiates naloxone from flumazenil in their respective mechanisms of action?

Receptor selectivity Signup and view all the answers

What is a key determinant of liver damage after paracetamol overdose?

Alanine transferase levels Signup and view all the answers