Podcast
Questions and Answers
What is the primary function of sulfonylureas in diabetes management?
What is the primary function of sulfonylureas in diabetes management?
Which medication class is most likely to cause flatulence and abdominal bloating?
Which medication class is most likely to cause flatulence and abdominal bloating?
What potential side effects are associated with thiazolidinediones (TZDs)?
What potential side effects are associated with thiazolidinediones (TZDs)?
What are DPP-4 inhibitors known to do in the context of GLP-1?
What are DPP-4 inhibitors known to do in the context of GLP-1?
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Which class of drugs is primarily used for patients with variable meal schedules?
Which class of drugs is primarily used for patients with variable meal schedules?
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Why was phenformin removed from the market?
Why was phenformin removed from the market?
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Which of the following is a characteristic of GLP-1 Receptor Agonists?
Which of the following is a characteristic of GLP-1 Receptor Agonists?
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What common adverse effect is shared by sulfonylureas and meglitinides?
What common adverse effect is shared by sulfonylureas and meglitinides?
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Study Notes
Antidiabetic Drugs
- Meglitinides (e.g., Repaglinide, Nateglinide): Used for patients with meal schedules that vary daily, increase risk of hypoglycemia.
- Biguanides (e.g., Metformin): Often used alone or with other medications, can cause lactic acidosis. Phenformin removed from market due to risk.
- Thiazolidinediones (e.g., Pioglitazone, Rosiglitazone): Used as an adjunct to diet and exercise for type 2 diabetes management. Can cause edema, increased plasma volume, and higher risk of heart failure. Rosiglitazone has a higher risk of heart attack than pioglitazone.
- α-Glucosidase Inhibitors (e.g., Acarbose, Miglitol): Cause flatulence and abdominal bloating.
- GLP-1 Receptor Agonists (GLP-1RAs) and DPP-4 Inhibitors: GLP-1 is quickly broken down, therefore it must be prepared as a sustained-release preparation for weekly use, e.g., Exenatide. Liraglutide is another example of a sustained-release.
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Description
This quiz covers various classes of antidiabetic drugs including Meglitinides, Biguanides, Thiazolidinediones, α-Glucosidase Inhibitors, and GLP-1 Receptor Agonists. It discusses their uses, side effects, and mechanisms. Test your knowledge on the important aspects of these medications!
