Antidepressants: TCA's vs. SSRI's

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46 Questions

What are the most commonly used drugs for bipolar disorder?

Lithium and valproate

Which drug used for bipolar disorder has a low therapeutic index?

Lithium

What adverse effect is associated with therapeutic doses of lithium?

Fine hand tremor

Which drug is used for psychotic mania and to prevent bipolar mania and depression?

Olanzapine

What can happen if there is low plasma sodium in a patient on lithium therapy?

Retention of lithium leading to toxicity

Which type of antidepressant selectively blocks the reuptake of serotonin into nerves?

Selective Serotonin Reuptake Inhibitors (SSRI’s)

What is a side effect associated with Tricyclic Antidepressants (TCA’s overdose?

Lower margin of safety

Which antidepressants have a black box warning for suicidal thinking in children, adolescents, and young adults?

Selective Serotonin Reuptake Inhibitors (SSRI’s)

Which drug is known to cause yawngasm as a side effect?

Clomipramine

What is the main therapeutic use of Selective Serotonin Reuptake Inhibitors (SSRI’s)?

Antidepressant effects

What are some common withdrawal symptoms associated with Selective Serotonin Reuptake Inhibitors (SSRI’s)?

Headache, nausea, anxiety

Which class of antidepressants is known for having effects similar to SSRI's but with more adverse effects?

Serotonin/norepinephrine reuptake inhibitors (SNRI’s)

Which atypical drug is known for its stimulant activity and is used for treating depression and smoking cessation?

Bupropion (Wellbutrin, Zyban)

Which adverse effect is commonly associated with Bupropion (Wellbutrin, Zyban)?

Agitation

Which neurotransmitters does Mirtazepine (Remeron) release?

NE and 5-HT

What severe adverse effect is associated with Monoamine Oxidase Inhibitors (MAOI’s) when taken with norepinephrine releasing drugs?

Hypertensive crisis

In the treatment of which disorder should St. John’s Wort be used with caution due to its potential to induce fluctuations in mood?

Bipolar Disorder

What is the main mechanism of action for tricyclic antidepressants (TCAs)?

Block the reuptake of norepinephrine and serotonin into nerves.

Which group of drugs is considered the second line for depression treatment due to a higher incidence of adverse effects?

Tricyclic antidepressants (TCAs)

What is the main neurotransmitter deficiency implicated in depression according to the text?

Norepinephrine (NE) and/or serotonin (5-HT)

Which class of drugs is commonly used as first-line treatment for neuropathic pain and fibromyalgia besides depression?

Tricyclic antidepressants (TCAs)

Which group of antidepressants typically takes weeks to develop their full therapeutic effects?

Tricyclic antidepressants (TCAs)

What is the main reason tricyclic antidepressants (TCAs) are not commonly used as first-line drugs for depression?

Longer time to reach maximal antidepressant effects.

What is the main reason for measuring plasma lithium levels when using lithium to treat bipolar disorder?

To ensure therapeutic levels and avoid toxicity

Which adverse effect is NOT associated with therapeutic doses of lithium in treating bipolar disorder?

Coarse tremor

Which neurotransmitter system is primarily affected by mood stabilizers like valproate in the treatment of bipolar disorder?

GABAergic system

What is a potential consequence of low plasma sodium levels in a patient on lithium therapy?

Risk of lithium toxicity

Which psychiatric symptom can olanzapine and risperidone help manage in bipolar disorder?

Psychotic mania

What is a common adverse effect associated with Venlafaxine (Effexor) and Duloxetine (Cymbalta)?

Hypertensive crisis

What is the primary mechanism of action of tricyclic antidepressants (TCA’s)?

Blocking the reuptake of dopamine and serotonin

Which group of antidepressants is characterized by a higher incidence of adverse effects and not commonly used as first-line drugs for depression treatment?

Tricyclic antidepressants (TCA’s)

Which atypical drug is known for causing little sexual dysfunction and common drowsiness?

Mirtazapine (Remeron)

Which adverse effect is commonly seen with Monoamine Oxidase Inhibitors (MAOIs) like Phenelzine (Nardil)?

Orthostatic hypotension

What neurotransmitter deficiency is associated with the monoamine neurotransmitter deficiency hypothesis of depression?

Serotonin and norepinephrine

What is the primary reason why Monoamine Oxidase Inhibitors (MAOIs) are considered third-line antidepressants?

High efficacy but severe adverse effects

Which antidepressant group typically requires months for maximal therapeutic effects to be achieved?

Tricyclic antidepressants (TCA’s)

Which drug is known to have a stimulant activity, no weight gain, and is used for smoking cessation?

Bupropion (Wellbutrin)

Which group of drugs is considered first-line for neuropathic pain and fibromyalgia treatment besides depression?

Tricyclic antidepressants (TCA’s)

What is a significant adverse effect associated with St. John’s Wort when used in individuals with bipolar disorder?

Mania

What is a common adverse effect associated with therapeutic doses of lithium in bipolar disorder treatment?

Hypothyroidism

Which group of antidepressants is associated with the risk of neonatal effects in newborns, such as abstinence syndrome and pulmonary hypertension?

Selective Serotonin Reuptake Inhibitors (SSRI’s)

Which class of antidepressants is known for causing withdrawal symptoms such as headache, nausea, anxiety, and dysphoria when the dose is tapered off?

Selective Serotonin Reuptake Inhibitors (SSRI’s)

Which antidepressant class is specifically noted for a side effect known as 'Yawngasm'?

Tricyclic Antidepressants (TCA’s)

Which class of antidepressants is considered the first-line treatment due to being effective with fewer adverse effects and developing maximal antidepressant effects in months?

Selective Serotonin Reuptake Inhibitors (SSRI’s)

Which type of antidepressants have a black box warning specifically for an increased risk of suicidal thinking and behavior in children, adolescents, and young adults?

Selective Serotonin Reuptake Inhibitors (SSRI’s)

Which class of antidepressants is noted to have a lower margin of safety in cases of overdose leading to cardiac arrhythmias and toxicity?

Tricyclic Antidepressants (TCA’s)

Test your knowledge on Tricyclic Antidepressants (TCA's) and Selective Serotonin Reuptake Inhibitors (SSRI's). Explore their mechanisms, therapeutic uses, side effects, and more in this quiz.

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