23 Questions
Which of the following best defines chronic pain?
Pain that persists beyond wound healing
Which of the following can cause neuropathic pain?
Peripheral nerve injury
What is hyperalgesia?
Reduced pain response threshold
Which of the following methods is used to induce inflammatory pain in animal models?
Injection of carrageenan
What is the purpose of using von Frey filaments in measuring responses to pain?
To assess mechanical allodynia
Which of the following is NOT a potential effect of chronic opioid use?
Increased analgesia
What happens to surviving primary afferents in cases of partial damage?
They sprout into pain pathways
Which of the following is a characteristic of opioids in treating chronic pain?
They have little/no effect on non-noxious afferents
Which type of VGCC is found in the central presynaptic terminals of afferents entering the spinal cord?
N-type VGCC
Which type of VGCC blocker is derived from cone-snail toxins?
N-type blockers
What is the mechanism of action of GABA analogues in treating neuropathic pain?
They reduce NT release by binding to VGCCs
What is the current 'best practice' approach to treating neuropathic pain?
GABA analogues
What are some side effects of GABA analogues in treating neuropathic pain?
Dizziness, sedation, memory loss
Which class of antidepressants includes amitriptyline and nortriptyline?
TCA's
Which neurotransmitters do antidepressants primarily target?
Norepinephrine and serotonin
Which receptors do some antidepressants have mixed actions at?
5-HT2, H1, H2, mAChR
Which neurotransmitter is involved in the mood modulation of pain pathways?
Serotonin
What is the mechanism of action of topical TRPV1 agonists like capsaicin?
Depletion of nociceptors
What is the function of TRPV1 receptors in the body?
Sensing painful heat
Which of the following is NOT a first-line treatment for neuropathic pain?
Ziconotide
What is the main mechanism of action of gabapentin and pregabalin in treating neuropathic pain?
Enhancement of GABA activity
Which type of chronic pain can be treated with topical capsaicin?
Neuropathic pain
Which class of drugs is considered a second-line treatment for neuropathic pain?
Opioids
Test your knowledge on classifying chronic pain with this informative quiz. Learn about the different types of chronic pain, including inflammatory pain, and understand how it can impact various aspects of life. Explore the multidimensional nature of chronic pain and its potential consequences.
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