Antidepressants: Pharmacology and Mechanism of Action

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What is the primary use of antidepressants?

Treating chronic pain

Treating depression (correct)

Treating obsessive-compulsive disorder

Treating anxiety disorders

What is the effect of SSRIs on serotonin levels in the synaptic cleft?

Increased (correct)

Unknown

No change

Decreased

Which type of antidepressant is used to treat fibromyalgia?

MAOIs

SSRIs

SNRIs (correct)

TCAs

What is the mechanism of action of TCAs?

Inhibiting the reuptake of serotonin and norepinephrine, and antagonizing histamine and muscarinic receptors Signup and view all the answers

What is the favorable side effect profile of SSRIs related to?

Clinical indications for use as first-line agents Signup and view all the answers

What is the primary mechanism of action of Monoamine Oxidase Inhibitors?

Inhibiting the activity of monoamine oxidase enzymes Signup and view all the answers

Which of the following antidepressants is a selective MAO-B inhibitor?

Selegiline Signup and view all the answers

What is a potential advantage of atypical antidepressants compared to traditional antidepressants?

Unique side effect profiles Signup and view all the answers

What is the primary reason why MAOIs are used less frequently than other antidepressants?

They have dietary restrictions and potential for drug interactions Signup and view all the answers

What is the purpose of combination therapy or augmentation therapy in treating depression?

To enhance the efficacy of antidepressants Signup and view all the answers

Antidepressants: Pharmacology and Mechanism of Action

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Questions and Answers

What is the primary use of antidepressants?

What is the effect of SSRIs on serotonin levels in the synaptic cleft?

Which type of antidepressant is used to treat fibromyalgia?

What is the mechanism of action of TCAs?

What is the favorable side effect profile of SSRIs related to?

What is the primary mechanism of action of Monoamine Oxidase Inhibitors?

Which of the following antidepressants is a selective MAO-B inhibitor?

What is a potential advantage of atypical antidepressants compared to traditional antidepressants?

What is the primary reason why MAOIs are used less frequently than other antidepressants?

What is the purpose of combination therapy or augmentation therapy in treating depression?

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