Antidepressants: Pharmacology and Mechanism of Action
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Questions and Answers

What is the primary use of antidepressants?

  • Treating chronic pain
  • Treating depression (correct)
  • Treating obsessive-compulsive disorder
  • Treating anxiety disorders

What is the effect of SSRIs on serotonin levels in the synaptic cleft?

  • Increased (correct)
  • Unknown
  • No change
  • Decreased

Which type of antidepressant is used to treat fibromyalgia?

  • MAOIs
  • SSRIs
  • SNRIs (correct)
  • TCAs

What is the mechanism of action of TCAs?

<p>Inhibiting the reuptake of serotonin and norepinephrine, and antagonizing histamine and muscarinic receptors (D)</p> Signup and view all the answers

What is the favorable side effect profile of SSRIs related to?

<p>Clinical indications for use as first-line agents (A)</p> Signup and view all the answers

What is the primary mechanism of action of Monoamine Oxidase Inhibitors?

<p>Inhibiting the activity of monoamine oxidase enzymes (D)</p> Signup and view all the answers

Which of the following antidepressants is a selective MAO-B inhibitor?

<p>Selegiline (B)</p> Signup and view all the answers

What is a potential advantage of atypical antidepressants compared to traditional antidepressants?

<p>Unique side effect profiles (D)</p> Signup and view all the answers

What is the primary reason why MAOIs are used less frequently than other antidepressants?

<p>They have dietary restrictions and potential for drug interactions (C)</p> Signup and view all the answers

What is the purpose of combination therapy or augmentation therapy in treating depression?

<p>To enhance the efficacy of antidepressants (D)</p> Signup and view all the answers

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