Antidepressants and Stress Impact Quiz

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What role does chronic stress play in the development of depression?

It increases neurogenesis in the brain.

It solely influences emotional responses without affecting neurobiology.

It reduces neurogenesis and damages neurons in specific brain regions. (correct)

It enhances memory and attention functions.

How do antidepressants contribute to neurogenesis in the brain?

They enhance the rapid development of previously damaged neurons.

They immediately restore cognitive functions.

They act only on the emotional symptoms of depression without neurobiological impact.

They promote neurogenesis slowly, correlating with their delayed effects. (correct)

What percentage of individuals with depression exhibit abnormal stress responses?

90%

25%

75%

50% (correct)

What is a common side effect associated with the use of tricyclic antidepressants (TCAs)?

Cognitive impairments Signup and view all the answers

What is a significant characteristic of antidepressants concerning neuronal health?

They promote the stability and health of newly formed neurons while protecting existing neurons. Signup and view all the answers

What is one way that stress impacts the hippocampus and frontal cortex?

It leads to structural damage and reduces neurogenesis. Signup and view all the answers

Which of the following best describes the mechanism of action of monoamine oxidase inhibitors (MAOIs)?

Inhibit MAO enzymes that degrade neurotransmitters Signup and view all the answers

What distinguishes reversible MAOIs from irreversible MAOIs?

They have a safer profile and transient inhibition of MAO Signup and view all the answers

Which therapeutic use is NOT typically associated with first-generation antidepressants?

Generalized anxiety disorder Signup and view all the answers

What dietary restriction is advised for patients taking MAOIs?

Avoiding tyramine-rich foods Signup and view all the answers

Which class of antidepressants primarily blocks the reuptake of serotonin?

Selective Serotonin Reuptake Inhibitors Signup and view all the answers

What is a significant risk associated with Paroxetine (Paxil)?

Serotonin syndrome Signup and view all the answers

Which antidepressant is known for being effective in smoking cessation without causing sexual dysfunction?

Bupropion (Wellbutrin) Signup and view all the answers

What is the typical duration for symptoms of serotonin syndrome to resolve after discontinuation of the offending drug?

24-48 hours Signup and view all the answers

What percentage of patients experience SSRI Discontinuation Syndrome after abruptly stopping SSRIs?

50-60% Signup and view all the answers

What is a significant risk associated with the use of 5-HT2 antagonists like Nefazodone?

Liver failure Signup and view all the answers

Which antidepressant is classified as a Specific Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)?

Mirtazapine Signup and view all the answers

What is a potential benefit of using Mirtazapine compared to traditional antidepressants?

Decreased sexual dysfunction Signup and view all the answers

Which of the following combinations may provide enhanced antidepressant action?

Olanzapine + Fluoxetine Signup and view all the answers

What is the relationship between folate and Major Depressive Disorder (MDD)?

Low folate levels are linked to MDD. Signup and view all the answers

What is Major Depressive Disorder (MDD) commonly known to be?

A chronic, recurring, and potentially life-threatening illness Signup and view all the answers

Which neurotransmitters are primarily associated with the Monoamine Hypothesis in relation to depression?

Serotonin, norepinephrine, and dopamine Signup and view all the answers

What is a common criticism of the Monoamine Hypothesis?

It lacks consistent findings on neurotransmitter levels Signup and view all the answers

What is the role of neurogenesis in the adult brain according to the neurogenic theory?

It is essential for producing new neurons throughout life Signup and view all the answers

Which statement accurately reflects the relationship between anxiety and depression?

Anxiety can be a comorbid condition that may require antidepressant treatment Signup and view all the answers

What primary treatment focus should be prioritized in managing depression?

Addressing both neurogenesis and neural repair Signup and view all the answers

What is a key advantage of antidepressants over benzodiazepines?

Less risk of dependence and abuse Signup and view all the answers

Which class of antidepressants blocks the presynaptic reuptake of serotonin and norepinephrine?

Tricyclic Antidepressants (TCAs) Signup and view all the answers

Which mechanism characterizes the action of Monoamine Oxidase Inhibitors (MAOIs)?

Inhibiting the MAO enzyme Signup and view all the answers

What significant shift was observed with the introduction of Selective Serotonin Reuptake Inhibitors (SSRIs)?

Fewer instances of overdose Signup and view all the answers