Antidepressant Mechanisms

Imipramine is known to induce seizure.

Doxepin is used for withdrawn patients.

Cocaine and amphetamines inhibit the uptake of NA and 5-HT.

REuptake inhibition of NA and 5-HT causes a decrease of these amines in the synaptic cleft.

Imipramine inhibits the uptake of DA, NA, and 5-HT.

Fluoxetine is used in depression and OCDs in adults only.

Trazodone has anticholinergic action.

Venlafaxine is a selective serotonin reuptake inhibitor.

Mirtazapine enhances the release of serotonin.

Bupropion is used in depression and cessation of smoking.

Paroxetine has a half-life of 2 days.

MAO-A inhibitors are mainly serotonergic.

SSRIs inhibit the reuptake of NA and dopamine.

MAO-B is primarily found in the brain and platelets.

Tranylcypromine is a reversible MAO inhibitor.

Moclobemide is an irreversible MAO inhibitor.

TCAs inhibit the reuptake of 5-HT and dopamine only.

The blockade of antidepressants starts immediately.

Postural hypotension is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs) in older patients.

α2 and 5-HT1 receptors are activated by a lack of NA/5HT.

Selective Serotonin Reuptake Inhibitors (SSRIs) can cause sedation and mental confusion.

Imipramine can interact with sympathomimetics to cause hypertensive crisis.

Imipramine undergoes minimal first-pass effect.

The therapeutic window of Imipramine is between 200-500 ng/ml.

Bupropion is an example of a Selective Serotonin Reuptake Inhibitor (SSRI).

Imipramine is primarily excreted through the feces.

Selective Serotonin Reuptake Inhibitors (SSRIs) can cause arrhythmia in patients with IHD.

Weight gain is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs).

Imipramine has a half-life of 6-8 hours.