Antidepressant Mechanisms
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Questions and Answers

Imipramine is known to induce seizure.

False (B)

Doxepin is used for withdrawn patients.

False (B)

Cocaine and amphetamines inhibit the uptake of NA and 5-HT.

False (B)

REuptake inhibition of NA and 5-HT causes a decrease of these amines in the synaptic cleft.

<p>False (B)</p> Signup and view all the answers

Imipramine inhibits the uptake of DA, NA, and 5-HT.

<p>False (B)</p> Signup and view all the answers

Fluoxetine is used in depression and OCDs in adults only.

<p>False (B)</p> Signup and view all the answers

Trazodone has anticholinergic action.

<p>False (B)</p> Signup and view all the answers

Venlafaxine is a selective serotonin reuptake inhibitor.

<p>False (B)</p> Signup and view all the answers

Mirtazapine enhances the release of serotonin.

<p>False (B)</p> Signup and view all the answers

Bupropion is used in depression and cessation of smoking.

<p>True (A)</p> Signup and view all the answers

Paroxetine has a half-life of 2 days.

<p>False (B)</p> Signup and view all the answers

MAO-A inhibitors are mainly serotonergic.

<p>False (B)</p> Signup and view all the answers

SSRIs inhibit the reuptake of NA and dopamine.

<p>False (B)</p> Signup and view all the answers

MAO-B is primarily found in the brain and platelets.

<p>True (A)</p> Signup and view all the answers

Tranylcypromine is a reversible MAO inhibitor.

<p>False (B)</p> Signup and view all the answers

Moclobemide is an irreversible MAO inhibitor.

<p>False (B)</p> Signup and view all the answers

TCAs inhibit the reuptake of 5-HT and dopamine only.

<p>False (B)</p> Signup and view all the answers

The blockade of antidepressants starts immediately.

<p>True (A)</p> Signup and view all the answers

Postural hypotension is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs) in older patients.

<p>False (B)</p> Signup and view all the answers

α2 and 5-HT1 receptors are activated by a lack of NA/5HT.

<p>False (B)</p> Signup and view all the answers

Selective Serotonin Reuptake Inhibitors (SSRIs) can cause sedation and mental confusion.

<p>False (B)</p> Signup and view all the answers

Imipramine can interact with sympathomimetics to cause hypertensive crisis.

<p>False (B)</p> Signup and view all the answers

Imipramine undergoes minimal first-pass effect.

<p>False (B)</p> Signup and view all the answers

The therapeutic window of Imipramine is between 200-500 ng/ml.

<p>False (B)</p> Signup and view all the answers

Bupropion is an example of a Selective Serotonin Reuptake Inhibitor (SSRI).

<p>False (B)</p> Signup and view all the answers

Imipramine is primarily excreted through the feces.

<p>False (B)</p> Signup and view all the answers

Selective Serotonin Reuptake Inhibitors (SSRIs) can cause arrhythmia in patients with IHD.

<p>False (B)</p> Signup and view all the answers

Weight gain is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs).

<p>False (B)</p> Signup and view all the answers

Imipramine has a half-life of 6-8 hours.

<p>False (B)</p> Signup and view all the answers

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