Anticonvulsant Medications: Uses and Adverse Reactions
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Questions and Answers

A patient taking carbamazepine (Tegretol) is exhibiting edema and increased blood pressure. Which of the following mechanisms is the MOST likely cause of these symptoms?

  • Promotion of antidiuretic hormone (ADH) secretion leading to fluid retention. (correct)
  • Decreased antidiuretic hormone (ADH) secretion causing dehydration.
  • Increased potassium excretion leading to fluid retention.
  • Inhibition of sodium reabsorption in the kidneys, causing fluid loss.

A patient is prescribed phenytoin (Dilantin). What common adverse effect requires diligent oral hygiene to manage?

  • Glossitis
  • Stomatitis
  • Xerostomia
  • Gingival Hyperplasia (correct)

A patient who has been taking an anticonvulsant reports experiencing double vision. Which of the following adverse reactions is the MOST likely cause?

  • Ataxia
  • Tinnitus
  • Diplopia (correct)
  • Nystagmus

Why is combining anticonvulsants with alcohol particularly dangerous?

<p>Both substances are CNS depressants, and their combined use can lead to excessive central nervous system depression. (D)</p> Signup and view all the answers

Which of the listed anticonvulsants is also commonly used to treat neuropathic pain?

<p>Gabapentin (Neurontin) (C)</p> Signup and view all the answers

A patient is prescribed lorazepam (Ativan) before surgery. What is the PRIMARY purpose of this medication in the pre-anesthetic setting?

<p>To relax the patient and alleviate anxiety (B)</p> Signup and view all the answers

Which of the following is a potentially life-threatening adverse reaction associated with lamotrigine (Lamictal)?

<p>Stevens-Johnson Syndrome (B)</p> Signup and view all the answers

What is the MOST important consideration regarding anticonvulsant use during pregnancy?

<p>There is a known association between anticonvulsant use and birth defects. (C)</p> Signup and view all the answers

A patient with a history of bipolar disorder and seizure disorder is being treated with valproic acid. During a routine check-up, the patient reports persistent nausea, vomiting, and severe abdominal pain. Which of the following is the MOST critical initial diagnostic step?

<p>Order liver function tests (LFTs) and amylase/lipase levels to assess for potential hepatotoxicity and pancreatitis. (C)</p> Signup and view all the answers

A pregnant patient with a pre-existing seizure disorder requires anticonvulsant therapy. Considering the teratogenic potential of many anticonvulsants, which agent, used judiciously and with appropriate monitoring, may be considered the LEAST teratogenic?

<p>Levetiracetam (Keppra) (B)</p> Signup and view all the answers

A patient is admitted to the emergency department experiencing status epilepticus. After administering the initial dose of diazepam, which of the following interventions is MOST critical in preventing respiratory depression and ensuring patient safety?

<p>Preparing for possible intubation and mechanical ventilation; closely monitoring respiratory rate, oxygen saturation, and level of consciousness. (D)</p> Signup and view all the answers

A patient on carbamazepine develops SIADH (syndrome of inappropriate antidiuretic hormone secretion). Beyond fluid restriction, which of the following pharmacological interventions would MOST directly address the underlying mechanism of carbamazepine-induced SIADH?

<p>Administering a vasopressin receptor antagonist (e.g., tolvaptan) to directly block the effects of ADH. (D)</p> Signup and view all the answers

An elderly patient with a history of renal impairment is prescribed gabapentin for neuropathic pain. What adjustments to the dosing regimen are MOST critical to prevent adverse effects?

<p>Initiate gabapentin at a significantly reduced starting dose and titrate slowly based on renal function and patient tolerance. (B)</p> Signup and view all the answers

A patient is started on lamotrigine and develops a rash. Which clinical feature would MOST strongly suggest that the rash is progressing towards Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN), necessitating immediate discontinuation of the medication?

<p>Rapidly spreading, painful rash with blistering, mucosal involvement (oral, ocular, genital), and systemic symptoms such as fever. (B)</p> Signup and view all the answers

A patient on long-term phenytoin therapy exhibits signs of cerebellar dysfunction. Which of the following mechanisms BEST explains this adverse effect?

<p>Direct neurotoxic effect of phenytoin metabolites on cerebellar Purkinje cells. (A)</p> Signup and view all the answers

Which of the following laboratory findings would be MOST concerning in a patient taking carbamazepine and warrant immediate discontinuation of the drug?

<p>Marked decrease in white blood cell (WBC) count with an absolute neutrophil count (ANC) below 1000/µL. (D)</p> Signup and view all the answers

A patient with a known seizure disorder and comorbid depression is being considered for anticonvulsant therapy. Which of the following anticonvulsants may offer dual benefits, potentially addressing both conditions?

<p>Lamotrigine (A)</p> Signup and view all the answers

A patient who has been successfully managed on Phenobarbital for years now requires a new medication to manage severe pain. What consideration regarding drug metabolism is MOST critical when adding opioid analgesics to this patient's regimen?

<p>Phenobarbital induces hepatic CYP450 enzymes; therefore, the opioid dose may need to be increased due to accelerated metabolism. (A)</p> Signup and view all the answers

Flashcards

Anticonvulsant Medications

Medications used to treat seizures and certain pain disorders.

Status Epilepticus

A medical emergency characterized by continuous seizures without interruption.

Valium

The drug of choice for treating status epilepticus, helps stop seizures.

CNS Depressant

Substances that suppress the central nervous system, reducing neuron activity.

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Common Adverse Reactions of Anticonvulsants

Include drowsiness, headache, and gastrointestinal issues.

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Gingival Hyperplasia

Overgrowth of gums commonly associated with phenytoin (Dilantin) use.

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Tegretol (Carbamazepine) Uses

Used for seizures, bipolar disorder, and promoting ADH secretion.

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Lyrica (Pregabalin)

Used for neuropathic pain and as an anticonvulsant.

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Anticonvulsants

Medications primarily used to treat all types of seizures.

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Common Side Effects

Common side effects include drowsiness and gastrointestinal issues.

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Serious Adverse Reactions

Serious reactions include Steven-Johnson Syndrome and pancytopenia.

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Phenobarbital

A barbiturate used as an anticonvulsant medication.

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Dilantin

Another name for phenytoin, known for causing gingival hyperplasia.

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Carbamazepine (Tegretol)

An anticonvulsant used for seizures and mood stabilizing in bipolar disorder.

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Benzodiazepines

A class including diazepam and lorazepam, used for seizures and anxiety.

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Valproic Acid (Depakote)

An anticonvulsant used for seizures and can cause liver damage.

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Magnesium Sulfate

Used to control seizures in eclampsia during pregnancy.

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Study Notes

Anticonvulsant Medications

  • Primarily used to treat seizures of all types
  • Also used for neuropathic pain, bipolar disorders, and anxiety disorders
  • Valium (diazepam) is the drug of choice for status epilepticus, a medical emergency of continuous seizures
  • Anticonvulsants are known as anti-epileptics and are central nervous system (CNS) depressants
  • Combining anticonvulsants with other CNS depressants (like alcohol) can worsen effects
  • Anticonvulsant use during pregnancy may be associated with birth defects

Adverse Reactions

  • Common: Drowsiness, headache, somnolence, nystagmus (involuntary eye movements), ataxia (lack of coordination), slurred speech, diplopia (double vision), gastrointestinal issues (nausea, vomiting, diarrhea, anorexia, constipation)
  • Gingival hyperplasia: Gum overgrowth, frequently seen with Dilantin (phenytoin)
  • Cardiovascular: Irregular heartbeat (dysrhythmias)
  • Skin: Rashes, particularly with Lamictal (lamotrigine)
  • Urinary: Increased frequency
  • Serious: Steven-Johnson Syndrome (serious skin reaction), pancytopenia (decrease in all blood cells), leukopenia, aplastic anemia, thrombocytopenia

Classification of Anticonvulsants

  • Barbiturates: Phenobarbital
  • Hydantoins: Phenytoin (Dilantin)
  • Succinimides: Ethosuximide
  • Sodium Channel Blockers: Carbamazepine (Tegretol)
  • Benzodiazepines: Diazepam (Valium), Lorazepam (Ativan)
  • Miscellaneous: Gabapentin (Neurontin), Pregabalin (Lyrica), Valproic Acid (Depakote), Topiramate (Topamax)

Additional Uses of Anticonvulsants

  • Lyrica (pregabalin): Neuropathic pain, postherpetic neuralgia, anticonvulsant
  • Ativan (lorazepam): Pre-anesthetic medication
  • Tegretol (carbamazepine): Bipolar disorder, neuralgia, increases ADH (antidiuretic hormone) potentially leading to fluid retention, edema, and heart failure.
  • Neurontin (gabapentin): Neuralgia
  • Magnesium Sulfate: Seizures in eclampsia (pregnant women) and acute nephritis in children.

Additional Uses and Side Effects

  • Depakote (valproic acid) and Topamax (topiramate): Migraine headaches
  • Depakote (valproic acid): Mania, hepatotoxic (liver damage), pancreatitis (inflammation of the pancreas)
  • Pancreatitis symptoms: Nausea, vomiting, abdominal pain

Contraindications and Interactions

  • Contraindications: Phenytoin: Heart block, pregnancy, lactation; Valproic Acid: Renal impairment, pregnancy; Carbamazepine: Bone marrow depression, hepatic impairment, pregnancy.
  • General Contraindication: All anticonvulsants should not be given within 14 days of monoamine oxidase inhibitors (MAOIs)
  • Interactions: Antibiotics and antifungals may increase anticonvulsant effects

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Description

This lesson covers anticonvulsant medications, their primary use in treating seizures, and their applications for neuropathic pain, bipolar disorders, and anxiety. It highlights common and severe adverse reactions including drowsiness, cardiovascular issues and skin rashes. It also advises against combining these depressants with other CNS depressants like alcohol.

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