Anticholinesterases in Myasthenia Gravis
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Questions and Answers

What is the main site of action of edrophonium, neostigmine, and pyridostigmine?

  • Motor neuron
  • Neuromuscular junction (NMJ) (correct)
  • Skeletal muscle
  • Muscle fibers

    • Why is edrophonium not used therapeutically for myasthenia gravis?

  • It is not effective in treating myasthenia gravis
  • It has severe visceral side effects
  • It is only used orally
  • It is too short-acting for therapeutic use (correct)

    • What might occur with very high doses of AChE inhibitors?

  • Increased muscle strength
  • Paradoxical weakness (correct)
  • Total remission of myasthenia gravis
  • Rapid disease progression

    • How do immunosuppressant drugs work in the treatment of myasthenia gravis?

    <p>By inhibiting Ab production (A)</p> Signup and view all the answers

    What is the mechanism of action of efgartigimod?

    <p>Binding to the neonatal Fc receptor and blocking its interaction with IgG (C)</p> Signup and view all the answers

    In what year was efgartigimod approved in the USA for the treatment of generalized myasthenia gravis?

    <p>2021 (A)</p> Signup and view all the answers

    What is the mechanism of action of eculizumab?

    <p>It inhibits the cleavage of complement protein C5 and prevents autoimmune damage (C)</p> Signup and view all the answers

    What is the indication of amifampridine?

    <p>Treatment of Lambert-Eaton myasthenic syndrome (C)</p> Signup and view all the answers

    What is the main side effect of eculizumab?

    <p>Headache (C)</p> Signup and view all the answers

    What is the underlying mechanism of Lambert-Eaton myasthenic syndrome?

    <p>Antitumor antibodies cross-reacting with Ca2+ channels on the presynaptic membrane (C)</p> Signup and view all the answers

    What is the role of tetraethylammonium (TEA) in the development of anticholinesterase drugs?

    <p>It is a ganglion-blocking drug that reverses the action of tubocurarine (D)</p> Signup and view all the answers

    What is the indication of eculizumab in neurology?

    <p>Treatment of neuromyelitis optica spectrum disorders (B)</p> Signup and view all the answers

    What is the primary function of anticholinesterase drugs in the treatment of Myasthenia Gravis?

    <p>Inhibiting the breakdown of acetylcholine at the neuromuscular junction (A)</p> Signup and view all the answers

    What is the characteristic of the quaternary amine structure of anticholinesterase drugs?

    <p>It makes the drug more hydrophilic (A)</p> Signup and view all the answers

    Which of the following is NOT a subtype of nicotinic acetylcholine receptors?

    <p>α2β1γ1 (A)</p> Signup and view all the answers

    What is the mechanism of action of direct-acting nicotinic stimulants, such as Neonicotinoids?

    <p>Acting as agonists on the postsynaptic nicotinic receptor (A)</p> Signup and view all the answers

    What is the effect of atropine treatment in Myasthenia Gravis?

    <p>Increasing the amount of acetylcholine available to bind to the nicotinic receptor (C)</p> Signup and view all the answers

    What is the primary function of the presynaptic nicotinic receptor in the neuromuscular junction?

    <p>Controlling the release of acetylcholine from the presynaptic neuron (C)</p> Signup and view all the answers

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