Anticholinesterases in Myasthenia Gravis
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Questions and Answers

What is the main site of action of edrophonium, neostigmine, and pyridostigmine?

  • Motor neuron
  • Neuromuscular junction (NMJ) (correct)
  • Skeletal muscle
  • Muscle fibers

Why is edrophonium not used therapeutically for myasthenia gravis?

  • It is not effective in treating myasthenia gravis
  • It has severe visceral side effects
  • It is only used orally
  • It is too short-acting for therapeutic use (correct)

What might occur with very high doses of AChE inhibitors?

  • Increased muscle strength
  • Paradoxical weakness (correct)
  • Total remission of myasthenia gravis
  • Rapid disease progression

How do immunosuppressant drugs work in the treatment of myasthenia gravis?

<p>By inhibiting Ab production (A)</p> Signup and view all the answers

What is the mechanism of action of efgartigimod?

<p>Binding to the neonatal Fc receptor and blocking its interaction with IgG (C)</p> Signup and view all the answers

In what year was efgartigimod approved in the USA for the treatment of generalized myasthenia gravis?

<p>2021 (A)</p> Signup and view all the answers

What is the mechanism of action of eculizumab?

<p>It inhibits the cleavage of complement protein C5 and prevents autoimmune damage (C)</p> Signup and view all the answers

What is the indication of amifampridine?

<p>Treatment of Lambert-Eaton myasthenic syndrome (C)</p> Signup and view all the answers

What is the main side effect of eculizumab?

<p>Headache (C)</p> Signup and view all the answers

What is the underlying mechanism of Lambert-Eaton myasthenic syndrome?

<p>Antitumor antibodies cross-reacting with Ca2+ channels on the presynaptic membrane (C)</p> Signup and view all the answers

What is the role of tetraethylammonium (TEA) in the development of anticholinesterase drugs?

<p>It is a ganglion-blocking drug that reverses the action of tubocurarine (D)</p> Signup and view all the answers

What is the indication of eculizumab in neurology?

<p>Treatment of neuromyelitis optica spectrum disorders (B)</p> Signup and view all the answers

What is the primary function of anticholinesterase drugs in the treatment of Myasthenia Gravis?

<p>Inhibiting the breakdown of acetylcholine at the neuromuscular junction (A)</p> Signup and view all the answers

What is the characteristic of the quaternary amine structure of anticholinesterase drugs?

<p>It makes the drug more hydrophilic (A)</p> Signup and view all the answers

Which of the following is NOT a subtype of nicotinic acetylcholine receptors?

<p>α2β1γ1 (A)</p> Signup and view all the answers

What is the mechanism of action of direct-acting nicotinic stimulants, such as Neonicotinoids?

<p>Acting as agonists on the postsynaptic nicotinic receptor (A)</p> Signup and view all the answers

What is the effect of atropine treatment in Myasthenia Gravis?

<p>Increasing the amount of acetylcholine available to bind to the nicotinic receptor (C)</p> Signup and view all the answers

What is the primary function of the presynaptic nicotinic receptor in the neuromuscular junction?

<p>Controlling the release of acetylcholine from the presynaptic neuron (C)</p> Signup and view all the answers

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