Anticholinesterases in Myasthenia Gravis

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What is the main site of action of edrophonium, neostigmine, and pyridostigmine?

Motor neuron

Neuromuscular junction (NMJ) (correct)

Skeletal muscle

Muscle fibers

Why is edrophonium not used therapeutically for myasthenia gravis?

It is not effective in treating myasthenia gravis

It has severe visceral side effects

It is only used orally

It is too short-acting for therapeutic use (correct)

What might occur with very high doses of AChE inhibitors?

Increased muscle strength

Paradoxical weakness (correct)

Total remission of myasthenia gravis

Rapid disease progression

How do immunosuppressant drugs work in the treatment of myasthenia gravis?

By inhibiting Ab production Signup and view all the answers

What is the mechanism of action of efgartigimod?

Binding to the neonatal Fc receptor and blocking its interaction with IgG Signup and view all the answers

In what year was efgartigimod approved in the USA for the treatment of generalized myasthenia gravis?

2021 Signup and view all the answers

What is the mechanism of action of eculizumab?

It inhibits the cleavage of complement protein C5 and prevents autoimmune damage Signup and view all the answers

What is the indication of amifampridine?

Treatment of Lambert-Eaton myasthenic syndrome Signup and view all the answers

What is the main side effect of eculizumab?

Headache Signup and view all the answers

What is the underlying mechanism of Lambert-Eaton myasthenic syndrome?

Antitumor antibodies cross-reacting with Ca2+ channels on the presynaptic membrane Signup and view all the answers

What is the role of tetraethylammonium (TEA) in the development of anticholinesterase drugs?

It is a ganglion-blocking drug that reverses the action of tubocurarine Signup and view all the answers

What is the indication of eculizumab in neurology?

Treatment of neuromyelitis optica spectrum disorders Signup and view all the answers

What is the primary function of anticholinesterase drugs in the treatment of Myasthenia Gravis?

Inhibiting the breakdown of acetylcholine at the neuromuscular junction Signup and view all the answers

What is the characteristic of the quaternary amine structure of anticholinesterase drugs?

It makes the drug more hydrophilic Signup and view all the answers

Which of the following is NOT a subtype of nicotinic acetylcholine receptors?

α2β1γ1 Signup and view all the answers

What is the mechanism of action of direct-acting nicotinic stimulants, such as Neonicotinoids?

Acting as agonists on the postsynaptic nicotinic receptor Signup and view all the answers

What is the effect of atropine treatment in Myasthenia Gravis?

Increasing the amount of acetylcholine available to bind to the nicotinic receptor Signup and view all the answers

What is the primary function of the presynaptic nicotinic receptor in the neuromuscular junction?

Controlling the release of acetylcholine from the presynaptic neuron Signup and view all the answers