Podcast
Questions and Answers
What is the main site of action of edrophonium, neostigmine, and pyridostigmine?
What is the main site of action of edrophonium, neostigmine, and pyridostigmine?
- Motor neuron
- Neuromuscular junction (NMJ) (correct)
- Skeletal muscle
- Muscle fibers
Why is edrophonium not used therapeutically for myasthenia gravis?
Why is edrophonium not used therapeutically for myasthenia gravis?
- It is not effective in treating myasthenia gravis
- It has severe visceral side effects
- It is only used orally
- It is too short-acting for therapeutic use (correct)
What might occur with very high doses of AChE inhibitors?
What might occur with very high doses of AChE inhibitors?
- Increased muscle strength
- Paradoxical weakness (correct)
- Total remission of myasthenia gravis
- Rapid disease progression
How do immunosuppressant drugs work in the treatment of myasthenia gravis?
How do immunosuppressant drugs work in the treatment of myasthenia gravis?
What is the mechanism of action of efgartigimod?
What is the mechanism of action of efgartigimod?
In what year was efgartigimod approved in the USA for the treatment of generalized myasthenia gravis?
In what year was efgartigimod approved in the USA for the treatment of generalized myasthenia gravis?
What is the mechanism of action of eculizumab?
What is the mechanism of action of eculizumab?
What is the indication of amifampridine?
What is the indication of amifampridine?
What is the main side effect of eculizumab?
What is the main side effect of eculizumab?
What is the underlying mechanism of Lambert-Eaton myasthenic syndrome?
What is the underlying mechanism of Lambert-Eaton myasthenic syndrome?
What is the role of tetraethylammonium (TEA) in the development of anticholinesterase drugs?
What is the role of tetraethylammonium (TEA) in the development of anticholinesterase drugs?
What is the indication of eculizumab in neurology?
What is the indication of eculizumab in neurology?
What is the primary function of anticholinesterase drugs in the treatment of Myasthenia Gravis?
What is the primary function of anticholinesterase drugs in the treatment of Myasthenia Gravis?
What is the characteristic of the quaternary amine structure of anticholinesterase drugs?
What is the characteristic of the quaternary amine structure of anticholinesterase drugs?
Which of the following is NOT a subtype of nicotinic acetylcholine receptors?
Which of the following is NOT a subtype of nicotinic acetylcholine receptors?
What is the mechanism of action of direct-acting nicotinic stimulants, such as Neonicotinoids?
What is the mechanism of action of direct-acting nicotinic stimulants, such as Neonicotinoids?
What is the effect of atropine treatment in Myasthenia Gravis?
What is the effect of atropine treatment in Myasthenia Gravis?
What is the primary function of the presynaptic nicotinic receptor in the neuromuscular junction?
What is the primary function of the presynaptic nicotinic receptor in the neuromuscular junction?