Anticholinergic Drugs

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Questions and Answers

Which of the following anticholinergic drugs is classified as a natural alkaloid?

  • Atropine methonitrate
  • Atropine (correct)
  • Ipratropium bromide
  • Tiotropium bromide

Which of the following anticholinergic drugs is used for the treatment of Parkinson's disease?

  • Flavoxate
  • Trihexyphenidyl (correct)
  • Oxybutynin
  • Tropicamide

Which of the following is a vesicoselective anticholinergic drug?

  • Tolterodine (correct)
  • Cyclopentolate
  • Biperiden
  • Tropicamide

A patient is prescribed an anticholinergic drug to dilate pupils before an eye exam. Which medication is most likely to be prescribed?

<p>Tropicamide (A)</p> Signup and view all the answers

Which of the following anticholinergic drugs is a tertiary amine?

<p>Dicyclomine (D)</p> Signup and view all the answers

Which of the following anticholinergic drugs is derived from the semisynthetic derivatives group?

<p>Homatropine (C)</p> Signup and view all the answers

Which of the following anticholinergic drugs is commonly associated with treating overactive bladder?

<p>Tolterodine (B)</p> Signup and view all the answers

Which of the following anticholinergic drugs is formulated as a quaternary ammonium compound?

<p>Glycopyrrolate (A)</p> Signup and view all the answers

A patient is experiencing motion sickness. Which anticholinergic drug is most appropriate for this condition?

<p>Hyoscine (Scopolamine) (A)</p> Signup and view all the answers

Which of the following is classified as an antisecretory-antispasmodic anticholinergic drug?

<p>Pirenzepine (A)</p> Signup and view all the answers

Among the listed options, identify the drug used as a mydriatic agent among anticholinergic drugs.

<p>Cyclopentolate (C)</p> Signup and view all the answers

A patient with chronic obstructive pulmonary disease (COPD) requires a bronchodilator. Which anticholinergic drug is most suitable for this patient?

<p>Tiotropium bromide (C)</p> Signup and view all the answers

Which of the following anticholinergic drugs is indicated for the treatment of irritable bowel syndrome (IBS)?

<p>Dicyclomine (A)</p> Signup and view all the answers

Which of the following best describes the primary mechanism of action of anticholinergic drugs?

<p>Blocking muscarinic receptors (B)</p> Signup and view all the answers

Identify the anticholinergic drug that is often used to reduce hyperhidrosis (excessive sweating).

<p>Glycopyrrolate (B)</p> Signup and view all the answers

Which of the following anticholinergic drugs acts as a M3 receptor antagonist?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following anticholinergic drug is a semisynthetic derivative used to induce mydriasis and cycloplegia for ophthalmic purposes?

<p>Homatropine (C)</p> Signup and view all the answers

Identify the anticholinergic drug that is administered via inhalation for the management of bronchospasm associated with chronic obstructive pulmonary disease (COPD).

<p>Ipratropium bromide (C)</p> Signup and view all the answers

A patient requires treatment for urinary incontinence with an anticholinergic agent that minimizes central nervous system side effects. Which drug is most appropriate?

<p>Tolterodine (B)</p> Signup and view all the answers

Which of the following anticholinergic drugs is used to prevent post-operative nausea and vomiting?

<p>Scopolamine (B)</p> Signup and view all the answers

Flashcards

Anticholinergic Drugs

Drugs that block the action of acetylcholine at muscarinic receptors, acting as muscarinic antagonists, atropinic drugs and parasympatholytics.

Natural alkaloids

Naturally occurring anticholinergic alkaloids.

Natural alkaloids examples

Examples include Atropine and Hyoscine (Scopolamine).

Semisynthetic derivatives

Anticholinergic drugs derived from natural alkaloids through chemical modification .

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Semisynthetic derivatives examples

Examples include Atropine methonitrate, Homatropine, Hyoscine butyl bromide, Ipratropium bromide and Tiotropium bromide.

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Synthetic compounds

Anticholinergic drugs produced through chemical synthesis.

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Mydriatics

Cause pupil dilation.

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Mydriatics examples

Examples include Cyclopentolate and Tropicamide.

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Vesicoselective

Reduce bladder spasms, treating overactive bladder.

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Vesicoselective examples

Examples include Oxybutynin, Flavoxate and Tolterodine.

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Antiparkinsonian

Used to treat Parkinson's disease, reducing tremors and rigidity.

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Antiparkinsonian examples

Include Trihexyphenidyl (Benzhexol), Procyclidine and Biperiden.

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Antisecretory-antispasmodics

Reduce gastrointestinal secretions and spasms.

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Quaternary Antisecretory-antispasmodics

Examples include Propantheline, Oxyphenonium and Clidinium.

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Tertiary Antisecretory-antispasmodics

Examples include Dicyclomine, Valethamate and Pirenzepine.

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Study Notes

  • Anticholinergic Drugs are also Muscarinic antagonists, Atropinic drugs, and Parasympatholytics

Natural alkaloids

  • Atropine
  • Hyoscine, also known as Scopolamine, is used for motion sickness

Semisynthetic derivatives

  • Atropine methonitrate
  • Homatropine
  • Hyoscine butyl bromide
  • Ipratropium bromide
  • Tiotropium bromide

Synthetic compounds

Mydriatics

  • Cyclopentolate
  • Tropicamide, used to fundoscopy refresh

Vasicoselective

  • Oxybutynin M3
  • Flavoxate M3
  • Tolterodine M3
  • These are selective to the overactive bladder

Antiparkinsonian

  • Trihexyphenidyl, also known as Benzhexol
  • Procyclidine
  • Biperiden

Antisecretory-antispasmodics

  • These are split into Quaternary and Tertiary amines
Quaternary comps.
  • Propantheline
  • Oxyphenonium
  • Clidinium
  • Pipenzolate methyl bromide
  • Isopropamide
  • Glycopyrrolate
Tertiary amines
  • Dicyclomine
  • Valethamate
  • Pirenzepine

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