11 Questions
What type of bonds hold the heavy and light chains of an antibody together?
Disulphide bonds
How many constant regions are possible for the heavy chain in humans?
4
What is the result of somatic recombination in the heavy chain locus?
Permanent change in the DNA
What is the role of the hypervariable regions in the antibody-antigen interaction?
To generate antigen specificity
What is the result of the combination of heavy and light chain variable regions?
A large range of antigen specificity
What type of regions flank the gene segments that undergo VDJ recombination?
23 base pair spacer and 12 base pair spacer
What is the primary function of the RAG1 protein?
To cleave the DNA at the RSS
What is the outcome of the cleavage reaction during VDJ recombination?
Formation of a hairpin structure
What is the role of Ku proteins during VDJ recombination?
To recruit DNA ligase
What is the result of somatic hypermutation during an immune response?
Increase in the diversity of the hypervariable region
In which location does somatic hypermutation occur?
In the germinal centres of lymph nodes
Test your knowledge on the structure and function of antibodies, including their domains, chains, and regions. Learn about the different types of light and heavy chains, and how they contribute to immune responses. Understand the role of constant regions in binding to effector cells.
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