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11 Questions

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Antibody Structure and Function

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Questions and Answers

What type of bonds hold the heavy and light chains of an antibody together?

Ionic bonds

Disulphide bonds (correct)

Hydrogen bonds

Peptide bonds

How many constant regions are possible for the heavy chain in humans?

4 (correct)

What is the result of somatic recombination in the heavy chain locus?

Temporary change in the DNA

No change in the DNA

Permanent change in the DNA (correct)

Removal of the V gene

What is the role of the hypervariable regions in the antibody-antigen interaction?

To generate antigen specificity Signup and view all the answers

What is the result of the combination of heavy and light chain variable regions?

A large range of antigen specificity Signup and view all the answers

What type of regions flank the gene segments that undergo VDJ recombination?

23 base pair spacer and 12 base pair spacer Signup and view all the answers

What is the primary function of the RAG1 protein?

To cleave the DNA at the RSS Signup and view all the answers

What is the outcome of the cleavage reaction during VDJ recombination?

Formation of a hairpin structure Signup and view all the answers

What is the role of Ku proteins during VDJ recombination?

To recruit DNA ligase Signup and view all the answers

What is the result of somatic hypermutation during an immune response?

Increase in the diversity of the hypervariable region Signup and view all the answers

In which location does somatic hypermutation occur?

In the germinal centres of lymph nodes Signup and view all the answers