18 Questions
What is the purpose of somatic mutation in differentiated B-cells?
To generate more diverse antibodies
Which gene regions are linked to the Class region in the Heavy chain of antibodies?
V and J regions
What process forms the variable region on the Heavy chain of antibodies?
VDJ Recombination
What is the primary immunoglobulin formed after the DNA loop is created and transcribed?
IgM
Which sequence is removed by RNA splicing in the Light Chain of antibodies?
J region
When does class switching occur in B cells?
After T helper cell interaction
What is the main immunoglobulin produced during secondary exposure to an antigen?
IgG
What is the main purpose of Class Switching in antibody production?
To enhance antibody specificity
What process leads to billions of different B cells with unique receptors for antigens?
VDJ Recombination
Which process in antibody production is similar to VDJ recombination and involves switch regions?
VDJ Recombination
Which cells express receptors for the Fc region of antibodies and participate in antibody-dependent cell-mediated cytotoxicity (ADCC)?
NK cells, monocytes, macrophages, and neutrophils
During which exposure to an antigen do antibodies appear in the blood within hours, mostly in the form of IgG antibodies?
Secondary exposure
What is recognized by phagocytes for opsonization?
Fc fragment
Which sequences flank the V, D, J sequences in VDJ recombination?
Recombination Signal Sequences (RSS)
What happens to unused J sequences in the VDJ recombination process?
They are removed by RNA splicing
What is the default constant region for B-cells in Ig production?
Cm (IgM)
Which cells differentiate into plasma cells after interacting with T helper cells?
B-cells
Which process involves a loop of DNA formation that is lost during antibody production?
Class switching
Test your knowledge about antibody structure and VDJ recombination process. Learn about the classes, isotypes, and the formation of variable regions on Heavy and Light chains.
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