Antibody Structure and VDJ Recombination Quiz

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What is the purpose of somatic mutation in differentiated B-cells?

To decrease antibody diversity

To inhibit antibody production

To increase the number of B cells

To generate more diverse antibodies (correct)

Which gene regions are linked to the Class region in the Heavy chain of antibodies?

D and J regions

Variable and Diversity regions

Joining and Constant regions

V and J regions (correct)

What process forms the variable region on the Heavy chain of antibodies?

Somatic Mutation

Class Switching

VDJ Recombination (correct)

RNA splicing

What is the primary immunoglobulin formed after the DNA loop is created and transcribed?

IgM Signup and view all the answers

Which sequence is removed by RNA splicing in the Light Chain of antibodies?

J region Signup and view all the answers

When does class switching occur in B cells?

After T helper cell interaction Signup and view all the answers

What is the main immunoglobulin produced during secondary exposure to an antigen?

IgG Signup and view all the answers

What is the main purpose of Class Switching in antibody production?

To enhance antibody specificity Signup and view all the answers

What process leads to billions of different B cells with unique receptors for antigens?

VDJ Recombination Signup and view all the answers

Which process in antibody production is similar to VDJ recombination and involves switch regions?

VDJ Recombination Signup and view all the answers

Which cells express receptors for the Fc region of antibodies and participate in antibody-dependent cell-mediated cytotoxicity (ADCC)?

NK cells, monocytes, macrophages, and neutrophils Signup and view all the answers

During which exposure to an antigen do antibodies appear in the blood within hours, mostly in the form of IgG antibodies?

Secondary exposure Signup and view all the answers

What is recognized by phagocytes for opsonization?

Fc fragment Signup and view all the answers

Which sequences flank the V, D, J sequences in VDJ recombination?

Recombination Signal Sequences (RSS) Signup and view all the answers

What happens to unused J sequences in the VDJ recombination process?

They are removed by RNA splicing Signup and view all the answers

What is the default constant region for B-cells in Ig production?

Cm (IgM) Signup and view all the answers

Which cells differentiate into plasma cells after interacting with T helper cells?

B-cells Signup and view all the answers

Which process involves a loop of DNA formation that is lost during antibody production?

Class switching Signup and view all the answers