Antibody Structure and VDJ Recombination Quiz
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Questions and Answers

What is the purpose of somatic mutation in differentiated B-cells?

  • To decrease antibody diversity
  • To inhibit antibody production
  • To increase the number of B cells
  • To generate more diverse antibodies (correct)

Which gene regions are linked to the Class region in the Heavy chain of antibodies?

  • D and J regions
  • Variable and Diversity regions
  • Joining and Constant regions
  • V and J regions (correct)

What process forms the variable region on the Heavy chain of antibodies?

  • Somatic Mutation
  • Class Switching
  • VDJ Recombination (correct)
  • RNA splicing

What is the primary immunoglobulin formed after the DNA loop is created and transcribed?

<p>IgM (B)</p> Signup and view all the answers

Which sequence is removed by RNA splicing in the Light Chain of antibodies?

<p>J region (D)</p> Signup and view all the answers

When does class switching occur in B cells?

<p>After T helper cell interaction (B)</p> Signup and view all the answers

What is the main immunoglobulin produced during secondary exposure to an antigen?

<p>IgG (A)</p> Signup and view all the answers

What is the main purpose of Class Switching in antibody production?

<p>To enhance antibody specificity (B)</p> Signup and view all the answers

What process leads to billions of different B cells with unique receptors for antigens?

<p>VDJ Recombination (C)</p> Signup and view all the answers

Which process in antibody production is similar to VDJ recombination and involves switch regions?

<p>VDJ Recombination (B)</p> Signup and view all the answers

Which cells express receptors for the Fc region of antibodies and participate in antibody-dependent cell-mediated cytotoxicity (ADCC)?

<p>NK cells, monocytes, macrophages, and neutrophils (B)</p> Signup and view all the answers

During which exposure to an antigen do antibodies appear in the blood within hours, mostly in the form of IgG antibodies?

<p>Secondary exposure (D)</p> Signup and view all the answers

What is recognized by phagocytes for opsonization?

<p>Fc fragment (C)</p> Signup and view all the answers

Which sequences flank the V, D, J sequences in VDJ recombination?

<p>Recombination Signal Sequences (RSS) (D)</p> Signup and view all the answers

What happens to unused J sequences in the VDJ recombination process?

<p>They are removed by RNA splicing (B)</p> Signup and view all the answers

What is the default constant region for B-cells in Ig production?

<p>Cm (IgM) (C)</p> Signup and view all the answers

Which cells differentiate into plasma cells after interacting with T helper cells?

<p>B-cells (D)</p> Signup and view all the answers

Which process involves a loop of DNA formation that is lost during antibody production?

<p>Class switching (B)</p> Signup and view all the answers

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