Podcast
Questions and Answers
What is the primary concern regarding the use of colistin-based combination therapy for A. baumannii disease?
What is the primary concern regarding the use of colistin-based combination therapy for A. baumannii disease?
- Higher cost compared to other antibiotic regimens
- Higher toxicity compared to monotherapy
- Increased risk of resistance development
- No significant difference in clinical response or mortality (correct)
What was the range of Fosfomycin's MIC values against 191 A. baumannii isolates?
What was the range of Fosfomycin's MIC values against 191 A. baumannii isolates?
- 128-8192 g/mL
- 1-16 g/mL
- 64-4096 g/mL
- 32-2048 g/mL (correct)
What is the primary reason why Fosfomycin and aminoglycosides are more effective than other antibiotics against A. baumannii?
What is the primary reason why Fosfomycin and aminoglycosides are more effective than other antibiotics against A. baumannii?
- The exact mechanism is not fully understood (correct)
- They have a lower MIC value
- They have a higher bactericidal efficacy
- They have a synergistic effect
What was the outcome of the time-kill kinetics experiments for the combination of Fosfomycin and conventional antibiotics against A. baumannii?
What was the outcome of the time-kill kinetics experiments for the combination of Fosfomycin and conventional antibiotics against A. baumannii?
What was the cumulative incidence of resistance development during Fosfomycin monotherapy in a 2017 analysis of 128 studies?
What was the cumulative incidence of resistance development during Fosfomycin monotherapy in a 2017 analysis of 128 studies?
What was the primary finding of a 2017 analysis of 128 studies regarding the clinical effectiveness of Fosfomycin compared to other antibiotics?
What was the primary finding of a 2017 analysis of 128 studies regarding the clinical effectiveness of Fosfomycin compared to other antibiotics?
What is the primary focus of the study conducted from January 2017 to June 2020?
What is the primary focus of the study conducted from January 2017 to June 2020?
What percentage of interactions were synergistic in the 2020 review?
What percentage of interactions were synergistic in the 2020 review?
Which bacteria had the highest susceptibility to Fosfomycin in the 2010-2015 study?
Which bacteria had the highest susceptibility to Fosfomycin in the 2010-2015 study?
What was the most common combination of antibiotics used in the study conducted from January 2017 to June 2020?
What was the most common combination of antibiotics used in the study conducted from January 2017 to June 2020?
What was the minimum inhibitory concentration of Fosfomycin in the 2021 study?
What was the minimum inhibitory concentration of Fosfomycin in the 2021 study?
What percentage of isolates showed resistance to Fosfomycin in the 2021 study?
What percentage of isolates showed resistance to Fosfomycin in the 2021 study?
What is the primary advantage of combining Fosfomycin with other antibiotics?
What is the primary advantage of combining Fosfomycin with other antibiotics?
In which bacteria was the most significant interaction observed with Daptomycin?
In which bacteria was the most significant interaction observed with Daptomycin?
What is the primary benefit of using Fosfomycin-based antibiotic combinations?
What is the primary benefit of using Fosfomycin-based antibiotic combinations?
What was the primary finding of the 2020 review regarding the interactions between Fosfomycin and other antibiotics?
What was the primary finding of the 2020 review regarding the interactions between Fosfomycin and other antibiotics?
What is the estimated number of cases of Acinetobacter baumannii reported annually globally?
What is the estimated number of cases of Acinetobacter baumannii reported annually globally?
What is the primary goal of the SENTRY Antimicrobial Surveillance Program?
What is the primary goal of the SENTRY Antimicrobial Surveillance Program?
What is the preferred treatment for Stenotrophomonas maltophilia infections?
What is the preferred treatment for Stenotrophomonas maltophilia infections?
What type of Acinetobacter is the most prevalent and resistant to penicillins by nature?
What type of Acinetobacter is the most prevalent and resistant to penicillins by nature?
What is the correlation found in the SENTRY Program investigation?
What is the correlation found in the SENTRY Program investigation?
What is the main reason for the decline in susceptibility rates to antimicrobials?
What is the main reason for the decline in susceptibility rates to antimicrobials?
What is the efficacy of Minocycline against extensively drug-resistant (XDR) Acb complex isolates?
What is the efficacy of Minocycline against extensively drug-resistant (XDR) Acb complex isolates?
What is the resistance rate of Sulbactam against Acinetobacter baumannii?
What is the resistance rate of Sulbactam against Acinetobacter baumannii?
What is the most common infection caused by Acinetobacter baumannii?
What is the most common infection caused by Acinetobacter baumannii?
What is the mortality rate linked to inappropriate empirical treatment for S.maltophilia infections?
What is the mortality rate linked to inappropriate empirical treatment for S.maltophilia infections?
What percentage of isolates showed multidrug resistance in a study in Dohuk province-Iraq?
What percentage of isolates showed multidrug resistance in a study in Dohuk province-Iraq?
What was the highest sensitivity rate found in a study in Dohuk province-Iraq?
What was the highest sensitivity rate found in a study in Dohuk province-Iraq?
What is the suggested effective therapy for severe CRAB infections?
What is the suggested effective therapy for severe CRAB infections?
What was the trend observed in susceptibility rates for all antimicrobial agents across regions?
What was the trend observed in susceptibility rates for all antimicrobial agents across regions?
What is the primary mechanism by which Smx and Tmp inhibit Csu assembly?
What is the primary mechanism by which Smx and Tmp inhibit Csu assembly?
What was the primary outcome in comparing TMP/SMX treatment to colistin or ampicillin–sulbactam treatment?
What was the primary outcome in comparing TMP/SMX treatment to colistin or ampicillin–sulbactam treatment?
What was the highest rate of extensively drug-resistant Acb complex isolates found in?
What was the highest rate of extensively drug-resistant Acb complex isolates found in?
What was the primary finding of the in vitro study comparing trimethoprim-sulfamethoxazole alone and combined with colistin?
What was the primary finding of the in vitro study comparing trimethoprim-sulfamethoxazole alone and combined with colistin?
What was the finding regarding the use of nebulized antibiotics in clinical trials for gram-negative ventilator-associated pneumonia?
What was the finding regarding the use of nebulized antibiotics in clinical trials for gram-negative ventilator-associated pneumonia?
What was the prevalence of A.baumannii in clinical samples in a study in Dohuk province-Iraq?
What was the prevalence of A.baumannii in clinical samples in a study in Dohuk province-Iraq?
What is a limitation of nebulized antibiotics in treating CRAB pneumonia?
What is a limitation of nebulized antibiotics in treating CRAB pneumonia?
What was the outcome of the three RCTs comparing nebulized antibiotics to placebo in gram-negative ventilator-associated pneumonia?
What was the outcome of the three RCTs comparing nebulized antibiotics to placebo in gram-negative ventilator-associated pneumonia?
What was the primary reason for the effectiveness of minocycline against S.maltophilia isolates?
What was the primary reason for the effectiveness of minocycline against S.maltophilia isolates?
What is the reason for the panel's advice against using nebulized antibiotics as supplementary therapy for CRAB pneumonia?
What is the reason for the panel's advice against using nebulized antibiotics as supplementary therapy for CRAB pneumonia?
What was the primary outcome of the study on fluoroquinolones as a substitute for TMP-SMX in the treatment of S.maltophilia infections?
What was the primary outcome of the study on fluoroquinolones as a substitute for TMP-SMX in the treatment of S.maltophilia infections?
What was the finding regarding the distribution of nebulized medicines in lung tissue?
What was the finding regarding the distribution of nebulized medicines in lung tissue?
What was the primary association found in patients treated with TMP/SMX?
What was the primary association found in patients treated with TMP/SMX?
What was the primary outcome of the study evaluating the effectiveness of TMP/SMX as a monotherapy for carbapenem-resistant Acinobacter baumannii infections?
What was the primary outcome of the study evaluating the effectiveness of TMP/SMX as a monotherapy for carbapenem-resistant Acinobacter baumannii infections?
What is the primary concern regarding the use of aerosolized colistin?
What is the primary concern regarding the use of aerosolized colistin?
What is the significance of the study on Acb complex and S.maltophilia isolates?
What is the significance of the study on Acb complex and S.maltophilia isolates?
What is the primary concern regarding antimicrobial resistance in Acinetobacter spp.?
What is the primary concern regarding antimicrobial resistance in Acinetobacter spp.?
What percentage of patients with pneumonia were caused by A. baumannii in the first trial?
What percentage of patients with pneumonia were caused by A. baumannii in the first trial?
What was the outcome of the three clinical studies comparing nebulized antibiotics to a placebo for the treatment of ventilator-associated pneumonia?
What was the outcome of the three clinical studies comparing nebulized antibiotics to a placebo for the treatment of ventilator-associated pneumonia?
What was the result of the systematic review and statistical analysis of 13 trials involving 1,733 adults with ventilator-associated pneumonia?
What was the result of the systematic review and statistical analysis of 13 trials involving 1,733 adults with ventilator-associated pneumonia?
What is the likely reason why nebulized antibiotics do not effectively penetrate and distribute throughout lung tissue?
What is the likely reason why nebulized antibiotics do not effectively penetrate and distribute throughout lung tissue?
What is the recommendation of the panel regarding the use of nebulized antibiotics as an additional treatment for CRAB pneumonia?
What is the recommendation of the panel regarding the use of nebulized antibiotics as an additional treatment for CRAB pneumonia?
What is the primary concern regarding the use of nebulized antibiotics?
What is the primary concern regarding the use of nebulized antibiotics?
What is the recommended treatment approach for moderate to severe CRAB infections according to the International Society for Antimicrobials?
What is the recommended treatment approach for moderate to severe CRAB infections according to the International Society for Antimicrobials?
What is the primary reason why nebulized antibiotics are not effective in treating ventilator-associated pneumonia?
What is the primary reason why nebulized antibiotics are not effective in treating ventilator-associated pneumonia?
What is the result of the PK/PD modeling research on administering the prodrug of colistin via aerosolization?
What is the result of the PK/PD modeling research on administering the prodrug of colistin via aerosolization?
What is the focus of recent years regarding Acinetobacter spp.?
What is the focus of recent years regarding Acinetobacter spp.?
What is the primary reason for the disparity in the effectiveness of Carbapenem and Sulbactam combination against CRAB infections?
What is the primary reason for the disparity in the effectiveness of Carbapenem and Sulbactam combination against CRAB infections?
What is the limitation of using Tigecycline in treating MDR Acinetobacter spp. infections?
What is the limitation of using Tigecycline in treating MDR Acinetobacter spp. infections?
What is the primary benefit of using combination therapy over monotherapy in treating MDR Acinetobacter spp. infections?
What is the primary benefit of using combination therapy over monotherapy in treating MDR Acinetobacter spp. infections?
Which of the following antibiotics is often used in combination with other antibiotics to treat MDR Acinetobacter spp. infections?
Which of the following antibiotics is often used in combination with other antibiotics to treat MDR Acinetobacter spp. infections?
What is the primary focus of further research into Sulbactam's effectiveness in treating MDR Acinetobacter spp. infections?
What is the primary focus of further research into Sulbactam's effectiveness in treating MDR Acinetobacter spp. infections?
What is the primary advantage of using combination therapy in treating MDR Acinetobacter spp. infections, especially in cases where the primary therapy is Polymyxins or Ampicillin/Sulbactam?
What is the primary advantage of using combination therapy in treating MDR Acinetobacter spp. infections, especially in cases where the primary therapy is Polymyxins or Ampicillin/Sulbactam?
What is the primary concern with nebulized antibiotics for CRAB pneumonia?
What is the primary concern with nebulized antibiotics for CRAB pneumonia?
What is the recommended approach for moderate to severe CRAB infections?
What is the recommended approach for moderate to severe CRAB infections?
What is the significance of High-dose Ampicillin/Sulbactam?
What is the significance of High-dose Ampicillin/Sulbactam?
What is the concern with Carbapenem-Polymyxin without Ampicillin/Sulbactam?
What is the concern with Carbapenem-Polymyxin without Ampicillin/Sulbactam?
What is the goal of Sulbactam MIC breakpoint studies?
What is the goal of Sulbactam MIC breakpoint studies?
What is the significance of Polymyxins in combination therapy?
What is the significance of Polymyxins in combination therapy?
What is the primary reason for the increased prevalence of CR-GNB?
What is the primary reason for the increased prevalence of CR-GNB?
What is the significance of Ampicillin/Sulbactam in combination therapy?
What is the significance of Ampicillin/Sulbactam in combination therapy?
What is the significance of Colistin in CR-GNB treatment?
What is the significance of Colistin in CR-GNB treatment?
What is the concern with Carbapenem-resistant Acinetobacter baumannii?
What is the concern with Carbapenem-resistant Acinetobacter baumannii?
What is the primary mechanism by which Colistin kills Gram-negative bacteria?
What is the primary mechanism by which Colistin kills Gram-negative bacteria?
What was the outcome of the study aimed to test the In-Vivo efficacy of Colistin combined with Meropenem, Tigecycline, Fosfomycin, Fusidic acid, Rifampin, or Sulbactam against XDR-AB infections?
What was the outcome of the study aimed to test the In-Vivo efficacy of Colistin combined with Meropenem, Tigecycline, Fosfomycin, Fusidic acid, Rifampin, or Sulbactam against XDR-AB infections?
What was the finding regarding the effectiveness of Colistin monotherapy in the study?
What was the finding regarding the effectiveness of Colistin monotherapy in the study?
What was the result of the combination of Colistin and Rifampin in the study?
What was the result of the combination of Colistin and Rifampin in the study?
What was the outcome of the multicenter, open-label, randomized study of life-threatening XDR-AB infections?
What was the outcome of the multicenter, open-label, randomized study of life-threatening XDR-AB infections?
What is the primary concern regarding the use of Colistin-based combination therapy for A. baumannii disease?
What is the primary concern regarding the use of Colistin-based combination therapy for A. baumannii disease?
What is the recommended approach for treating CRAB infections according to the IDSA panel?
What is the recommended approach for treating CRAB infections according to the IDSA panel?
What was the finding regarding the correlation between Colistin and nephrotoxicity?
What was the finding regarding the correlation between Colistin and nephrotoxicity?
What is the primary benefit of using combination therapy for CRAB infections?
What is the primary benefit of using combination therapy for CRAB infections?
What was the finding regarding the effectiveness of Tigecycline in combination therapy for CRAB infections?
What was the finding regarding the effectiveness of Tigecycline in combination therapy for CRAB infections?
