10 Questions
What is the primary cause of angina pectoris?
Insufficient coronary blood flow
Which risk factor is NOT associated with angina?
Regular physical activity
What type of angina is associated with atheromatous plaques that partially occlude one or more coronary arteries?
Atherosclerotic angina
What type of pain is characteristic of atherosclerotic angina?
Sudden, severe, crushing chest pain radiating to the neck, jaw, back, and arms
What percentage of angina cases does atherosclerotic angina constitute?
90%
What is the main cause of vasospastic angina?
Reversible spasm of coronaries
Which of the following is NOT a pharmacologic therapy for angina?
Platelet aggregation inhibitors
What is the primary role of nitric oxide (NO) in the cardiovascular system?
Mediate relaxation of the corpus cavernosum
What was prescribed to Alfred Nobel to ease his chest pain when he developed angina in 1890?
Glyceryl trinitrate (nitroglycerin)
Why should nitroglycerin tablets be kept in tightly closed glass containers?
To avoid plastic surface adsorption
Study Notes
Angina Pectoris
- Primary cause of angina pectoris: reduction in blood flow to the heart muscle due to coronary artery disease
Risk Factors
- NOT associated with angina: unknown
Types of Angina
- Atherosclerotic angina: associated with atheromatous plaques that partially occlude one or more coronary arteries
- Characteristic pain of atherosclerotic angina: squeezing, pressure, or tightness in the chest, arm, or jaw
- Atherosclerotic angina constitutes: approximately 90% of angina cases
Vasospastic Angina
- Main cause: coronary artery spasm
- Pain pattern: recurrent episodes of chest pain at rest, often during the night or early morning hours
Pharmacologic Therapy for Angina
- NOT a pharmacologic therapy for angina: antibiotics
Nitric Oxide (NO)
- Primary role in the cardiovascular system: vasodilation, reducing blood pressure
Historical Note
- Alfred Nobel's treatment for angina in 1890: nitroglycerin
Nitroglycerin
- Storage requirements: tightly closed glass containers to prevent degradation by moisture and light
Test your knowledge of anti-anginal drugs and their mechanisms with this quiz. Explore topics such as organic nitrates, β-blockers, calcium channel blockers, and other medications used to treat angina.
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