Anti-emetics and Anti-vertigo Drugs
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Questions and Answers

Which of the following antiemetic classes is associated with the antagonism of dopamine D2 receptors?

  • Selective 5-HT3 Antagonists
  • H1 Antihistamines
  • D2 Antagonists (correct)
  • Muscarinic Antagonists
  • Which antiemetic is a selective 5-HT3 antagonist and is used to treat chemotherapy-induced nausea and vomiting?

  • Metoclopramide
  • Diphenhydramine
  • Hyoscine
  • Ondansetron (correct)
  • Which antiemetic class is associated with the blockade of muscarinic receptors?

  • Selective 5-HT3 Antagonists
  • D2 Antagonists
  • H1 Antihistamines
  • Muscarinic Antagonists (correct)
  • What is the mechanism of action of Metoclopramide as a prokinetic agent?

    <p>Blocks the normal inhibitory effect of dopamine on cholinergic smooth muscle stimulation</p> Signup and view all the answers

    Which of the following antiemetics is a cannabinoid?

    <p>Dronabinol</p> Signup and view all the answers

    What is the primary site of action of Metoclopramide as an antiemetic?

    <p>Chemoreceptor Trigger Zone (CTZ) of the medulla</p> Signup and view all the answers

    Which of the following antiemetics does not cross the blood-brain barrier?

    <p>Domperidone</p> Signup and view all the answers

    What is the primary mechanism of action of phenothiazines as antiemetics?

    <p>D2 antagonism and anti-muscarinic properties</p> Signup and view all the answers

    Which of the following adverse effects is commonly associated with phenothiazines?

    <p>Extrapyramidal symptoms</p> Signup and view all the answers

    Which of the following selective 5-HT3 antagonists has a longer half-life?

    <p>Palonosetron</p> Signup and view all the answers

    What is the main advantage of using domperidone in patients taking levodopa?

    <p>It does not affect the efficacy of levodopa</p> Signup and view all the answers

    Which of the following antiemetics is used to treat nausea and vomiting caused by chemotherapy?

    <p>Ondansetron</p> Signup and view all the answers

    Which type of receptors are rich in the vestibular system, contributing to motion sickness?

    <p>Cholinergic M1 &amp; Histamine H1</p> Signup and view all the answers

    What is the primary mechanism of action of H1 antihistamines in treating motion sickness?

    <p>Inhibiting the influx of calcium to vestibular sensory cells</p> Signup and view all the answers

    What is the primary pharmacokinetic characteristic of dronabinol?

    <p>Complete absorption with significant first-pass effect</p> Signup and view all the answers

    Which of the following drugs is used to reduce anticipatory vomiting prior to cancer chemotherapy?

    <p>Diazepam</p> Signup and view all the answers

    What is the primary advantage of meclizine over other H1 antihistamines in treating motion sickness?

    <p>It has a longer duration of action</p> Signup and view all the answers

    What is the primary mechanism of action of cannabinoids in treating nausea and vomiting?

    <p>Acting as antiemetics and appetite stimulants</p> Signup and view all the answers

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