Anti-emetics and Anti-vertigo Drugs
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Questions and Answers

Which of the following antiemetic classes is associated with the antagonism of dopamine D2 receptors?

  • Selective 5-HT3 Antagonists
  • H1 Antihistamines
  • D2 Antagonists (correct)
  • Muscarinic Antagonists

Which antiemetic is a selective 5-HT3 antagonist and is used to treat chemotherapy-induced nausea and vomiting?

  • Metoclopramide
  • Diphenhydramine
  • Hyoscine
  • Ondansetron (correct)

Which antiemetic class is associated with the blockade of muscarinic receptors?

  • Selective 5-HT3 Antagonists
  • D2 Antagonists
  • H1 Antihistamines
  • Muscarinic Antagonists (correct)

What is the mechanism of action of Metoclopramide as a prokinetic agent?

<p>Blocks the normal inhibitory effect of dopamine on cholinergic smooth muscle stimulation (B)</p> Signup and view all the answers

Which of the following antiemetics is a cannabinoid?

<p>Dronabinol (D)</p> Signup and view all the answers

What is the primary site of action of Metoclopramide as an antiemetic?

<p>Chemoreceptor Trigger Zone (CTZ) of the medulla (B)</p> Signup and view all the answers

Which of the following antiemetics does not cross the blood-brain barrier?

<p>Domperidone (C)</p> Signup and view all the answers

What is the primary mechanism of action of phenothiazines as antiemetics?

<p>D2 antagonism and anti-muscarinic properties (C)</p> Signup and view all the answers

Which of the following adverse effects is commonly associated with phenothiazines?

<p>Extrapyramidal symptoms (C)</p> Signup and view all the answers

Which of the following selective 5-HT3 antagonists has a longer half-life?

<p>Palonosetron (C)</p> Signup and view all the answers

What is the main advantage of using domperidone in patients taking levodopa?

<p>It does not affect the efficacy of levodopa (D)</p> Signup and view all the answers

Which of the following antiemetics is used to treat nausea and vomiting caused by chemotherapy?

<p>Ondansetron (B)</p> Signup and view all the answers

Which type of receptors are rich in the vestibular system, contributing to motion sickness?

<p>Cholinergic M1 &amp; Histamine H1 (A)</p> Signup and view all the answers

What is the primary mechanism of action of H1 antihistamines in treating motion sickness?

<p>Inhibiting the influx of calcium to vestibular sensory cells (C)</p> Signup and view all the answers

What is the primary pharmacokinetic characteristic of dronabinol?

<p>Complete absorption with significant first-pass effect (A)</p> Signup and view all the answers

Which of the following drugs is used to reduce anticipatory vomiting prior to cancer chemotherapy?

<p>Diazepam (C)</p> Signup and view all the answers

What is the primary advantage of meclizine over other H1 antihistamines in treating motion sickness?

<p>It has a longer duration of action (D)</p> Signup and view all the answers

What is the primary mechanism of action of cannabinoids in treating nausea and vomiting?

<p>Acting as antiemetics and appetite stimulants (B)</p> Signup and view all the answers

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