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Questions and Answers
At what temperature does anthraquinone sublimate?
At what temperature does anthraquinone sublimate?
- 200-220 oC
- 160-180 oC (correct)
- 220-240 oC
- 100-120 oC
What is the color change observed when the sublimate of anthraquinone reacts with alkali?
What is the color change observed when the sublimate of anthraquinone reacts with alkali?
- Yellow
- Blue
- Green
- Red (correct)
Which acid is used in Borntrager’s test for anthraquinones?
Which acid is used in Borntrager’s test for anthraquinones?
- Acetic acid
- Strong sulfuric acid
- Dilute hydrochloric acid (correct)
- Concentrated nitric acid
What is the result of boiling anthraquinone glycoside with hydrochloric acid?
What is the result of boiling anthraquinone glycoside with hydrochloric acid?
What physical forms are yielded when anthraquinone sublimes?
What physical forms are yielded when anthraquinone sublimes?
What is the scientific name of the plant known as Senna tora?
What is the scientific name of the plant known as Senna tora?
Which part of the Senna tora plant is primarily used for medicinal purposes?
Which part of the Senna tora plant is primarily used for medicinal purposes?
Which of the following compounds is NOT listed as a key ingredient found in Senna tora?
Which of the following compounds is NOT listed as a key ingredient found in Senna tora?
What is a recognized use of Senna tora according to traditional practices?
What is a recognized use of Senna tora according to traditional practices?
Which family does the Senna tora plant belong to?
Which family does the Senna tora plant belong to?
What is one of the primary uses of St. John's Wort as an external treatment?
What is one of the primary uses of St. John's Wort as an external treatment?
Which compound in St. John's Wort is linked to photosensitivity?
Which compound in St. John's Wort is linked to photosensitivity?
What serious condition can occur when St. John's Wort is used with selective serotonin reuptake inhibitors (SSRIs)?
What serious condition can occur when St. John's Wort is used with selective serotonin reuptake inhibitors (SSRIs)?
Which of the following is a common side effect of St. John's Wort?
Which of the following is a common side effect of St. John's Wort?
What effect does St. John's Wort have on the central nervous system when combined with SSRIs?
What effect does St. John's Wort have on the central nervous system when combined with SSRIs?
In terms of drug interaction, what role does St. John's Wort play as an inducer?
In terms of drug interaction, what role does St. John's Wort play as an inducer?
What is a potential gastrointestinal side effect of St. John's Wort?
What is a potential gastrointestinal side effect of St. John's Wort?
Which of the following symptoms is NOT associated with serotonin syndrome from St. John's Wort?
Which of the following symptoms is NOT associated with serotonin syndrome from St. John's Wort?
What part of the plant Boraginaceae is primarily used for medicinal purposes?
What part of the plant Boraginaceae is primarily used for medicinal purposes?
Which compound is primarily responsible for the red color in the root of Boraginaceae?
Which compound is primarily responsible for the red color in the root of Boraginaceae?
What is one of the primary uses of alkannin and shikonin?
What is one of the primary uses of alkannin and shikonin?
Which of the following properties is NOT associated with Boraginaceae?
Which of the following properties is NOT associated with Boraginaceae?
Which condition can Boraginaceae roots help treat?
Which condition can Boraginaceae roots help treat?
Which plant part is used from St. John’s Wort?
Which plant part is used from St. John’s Wort?
Which of the following is a known application of the Boraginaceae family in cosmetics?
Which of the following is a known application of the Boraginaceae family in cosmetics?
What is a significant role of alkannin and shikonin in medicine?
What is a significant role of alkannin and shikonin in medicine?
What is the effect of using Boraginaceae for external wounds?
What is the effect of using Boraginaceae for external wounds?
Which of the following is NOT a known benefit of Boraginaceae?
Which of the following is NOT a known benefit of Boraginaceae?
Which of the following is a common structure found in anthraquinones?
Which of the following is a common structure found in anthraquinones?
Anthraquinones can be found in which of the following plant families?
Anthraquinones can be found in which of the following plant families?
Which of the following describes the form in which anthraquinones usually occur in plants?
Which of the following describes the form in which anthraquinones usually occur in plants?
What is the most common structural variation of anthraquinones found in plants?
What is the most common structural variation of anthraquinones found in plants?
Which type of glycoside is more commonly found in anthraquinones?
Which type of glycoside is more commonly found in anthraquinones?
What functional groups are predominantly present in the basic structure of anthraquinones?
What functional groups are predominantly present in the basic structure of anthraquinones?
Which of the following anthraquinones is an example of an O-glycoside?
Which of the following anthraquinones is an example of an O-glycoside?
In what kind of chemical structure do anthraquinones generally exist?
In what kind of chemical structure do anthraquinones generally exist?
What is one of the primary roles of anthraquinones in plants?
What is one of the primary roles of anthraquinones in plants?
Which of the following statements is false regarding anthraquinones?
Which of the following statements is false regarding anthraquinones?
What is a common side effect of stimulant laxatives?
What is a common side effect of stimulant laxatives?
Which condition should stimulant laxatives be avoided in?
Which condition should stimulant laxatives be avoided in?
What can excessive use of stimulant laxatives lead to?
What can excessive use of stimulant laxatives lead to?
In which population is the use of stimulant laxatives particularly cautioned?
In which population is the use of stimulant laxatives particularly cautioned?
What is a potential metabolic effect of continuous use of stimulant laxatives?
What is a potential metabolic effect of continuous use of stimulant laxatives?
What should be done if symptoms such as abdominal pain and rectal bleeding occur after taking stimulant laxatives?
What should be done if symptoms such as abdominal pain and rectal bleeding occur after taking stimulant laxatives?
Which digestive condition is specifically mentioned as a contraindication for stimulant laxatives?
Which digestive condition is specifically mentioned as a contraindication for stimulant laxatives?
What is an important precaution regarding the duration of use for stimulant laxatives?
What is an important precaution regarding the duration of use for stimulant laxatives?
What type of laxative is specifically classified as a stimulant laxative?
What type of laxative is specifically classified as a stimulant laxative?
What should be avoided when using stimulant laxatives?
What should be avoided when using stimulant laxatives?
Flashcards
Microsublimation Test
Microsublimation Test
A test used to identify the presence of anthraquinones, a class of organic compounds often found in plants.
Anthraquinone
Anthraquinone
A specific type of anthraquinone that can be identified using the microsublimation test. Anthraquinones are often present in plants and are used in various applications, such as dyes and pharmaceuticals.
Sublimation
Sublimation
The process of a solid changing directly into a gas, skipping the liquid phase. This occurs when heating anthraquinones during the microsublimation test.
Red Color Reaction with Alkali
Red Color Reaction with Alkali
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Borntrager's Test
Borntrager's Test
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Senna Tora
Senna Tora
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Fabaceae
Fabaceae
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Chrysophanol
Chrysophanol
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Aloe-emodin
Aloe-emodin
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Stimulant Laxative
Stimulant Laxative
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Riththi
Riththi
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Abdominal Discomfort
Abdominal Discomfort
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Diarrhea and Dehydration
Diarrhea and Dehydration
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Electrolyte Imbalance
Electrolyte Imbalance
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Quinones
Quinones
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Herbal Remedies for Skin Infections
Herbal Remedies for Skin Infections
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External Use of Herbal Remedies
External Use of Herbal Remedies
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Contraindications of Riththi
Contraindications of Riththi
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Precautions with Riththi
Precautions with Riththi
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St. John's Wort
St. John's Wort
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CYP450 Inducer
CYP450 Inducer
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Selective Serotonin Reuptake Inhibitor (SSRI)
Selective Serotonin Reuptake Inhibitor (SSRI)
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Serotonin Syndrome
Serotonin Syndrome
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Hypericin
Hypericin
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Photosensitivity
Photosensitivity
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Neurological and Gastrointestinal Side Effects
Neurological and Gastrointestinal Side Effects
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Herb-Drug Interaction
Herb-Drug Interaction
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What is Alkanna?
What is Alkanna?
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What is alkannin?
What is alkannin?
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What makes Alkanna a useful plant?
What makes Alkanna a useful plant?
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What do Alkanna and Gromwell have in common?
What do Alkanna and Gromwell have in common?
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How are shikonin and alkannin used?
How are shikonin and alkannin used?
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Where do we use Alkanna's red pigments?
Where do we use Alkanna's red pigments?
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What are the potential benefits of Alkanna root?
What are the potential benefits of Alkanna root?
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What specific ailments can Alkanna be used to treat?
What specific ailments can Alkanna be used to treat?
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What are some of the key properties of Alkanna root?
What are some of the key properties of Alkanna root?
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Why is Alkanna a significant plant?
Why is Alkanna a significant plant?
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What are Quinones?
What are Quinones?
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What are Anthraquinones?
What are Anthraquinones?
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Where are Anthraquinones found in plants?
Where are Anthraquinones found in plants?
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What forms can Anthraquinones exist in?
What forms can Anthraquinones exist in?
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Describe the basic structure of Anthraquinone.
Describe the basic structure of Anthraquinone.
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What are some reduced forms of Anthraquinones?
What are some reduced forms of Anthraquinones?
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What are O-glycosides?
What are O-glycosides?
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What are C-glycosides?
What are C-glycosides?
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How are Anthraquinones commonly found in plants?
How are Anthraquinones commonly found in plants?
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What are Anthraquinones with two hydroxyl groups at positions 1 and 8 called?
What are Anthraquinones with two hydroxyl groups at positions 1 and 8 called?
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Study Notes
Quinones
- Quinones are organic compounds derived from aromatic compounds like benzene, naphthalene, or anthracene.
- Anthraquinones (AQs) are the most common naturally occurring quinones.
- AQs are found in both monocots and dicots across various plant families.
- AQs can exist in free form or as glycosides.
Structure of Anthraquinones
- The basic structure of anthraquinone is 9,10-dioxoanthracene.
- It's derived from anthracene and has two keto groups, typically at positions 9 and 10.
- Anthraquinones often exist in a reduced form, such as anthrone, anthranol, oxanthrone, or dianthrone.
- AQs frequently occur in plants as glycosides; oxygen-linked glycosides (O-glycosides) are more common than carbon-linked glycosides (C-glycosides).
Classification of Anthraquinones
- Anthraquinones can be classified into several categories based on their structure and characteristics.
- Anthraquinones: Found in orange-red compounds, typically hydroxylated at positions 1 and 8. Types include: rhein, aloe-emodin, chrysophanol, emodin, and physcion.
- Anthrones and Anthranols: Reduced form of anthraquinones. Types include: emodin anthranol, chrysophanol anthranol and chrysophanol. They are isomers and are frequently found in plants.
- Oxanthrones: Intermediate compounds between anthraquinones and anthrones/anthranols. Types include: Emodin oxanthrones.
- Aloin-type glycosides: C-glycoside that sugar part linked at C10 of the core structure with a C−C bond. Types include: aloin and chrysaloin.
- Dianthrones: Derived from two anthrone molecules. Types include: sennidin A, sennidin B, palmidin A, and palmidin B.
Biosynthesis of Anthraquinones
- Two major pathways are used for anthraquinones biosynthesis:
- Acetate pathway
- Shikimate-mevalonate pathway
Tests for Anthraquinones
- Microsublimation test: Anthraquinone sublimates at 160-180°C, forming needles or droplets, and gives a red color with alkali (ammonium hydroxide or potassium hydroxide).
- Borntrager's test: The sample is boiled with dilute HCl, then extracted with dichloromethane. Adding ammonium hydroxide to the extract results in a pink to red color, indicating the presence of anthraquinone.
- Modified Borntrager's test: Used for C-type glycosides, a stronger oxidizing agent is required (e.g., peroxide) to hydrolyze the glycoside.
Pharmaceutical Uses Of Anthraquinones
- Anthraquinones, especially their aglycone forms in anthrones and anthranols, have stimulant laxative properties due to their effect on colon contractions and water secretion.
- Anthraquinones also exhibit antimicrobial, antioxidant, and anti-inflammatory activity, among others.
- Naphthoquinones (e.g., plumbagin) have antimicrobial, antitumor, and anti-inflammatory effects.
- Some anthraquinones are used in traditional medicine as a topical remedies for skin conditions.
Plant Samples
- Different plants contain various anthraquinones.
- Examples include aloe vera, senna, rhubarb, henna, gromwell, alkanna, and St. John's Wort.
St. John's Wort
- Contains hypericin and pseudohypericin, which are naphthodianthrones.
- Also contains prenylated phloroglucinols (e.g., hyperforin) and flavonoids.
- Used as an antidepressant for mild to moderate depression.
Discussion Points
- The different types of anthraquinone compounds found in various plants.
- The structural variations in plants contributing to the medicinal properties.
- The different methods of analysis and extraction of these compounds.
- The importance of plant identification and standardization in herbal medicine.
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