Anthelmintic Drugs Classification

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How are the components of plants and their proportions determined for anthelmintic effect?

Through Gas Chromatography-Mass Spectrometry (GC-MS) or High-Performance Liquid Chromatography (HPLC) analysis

What are the two groups into which anthelmintic drugs are roughly divided?

Vermifuges (Expel helminths from body) and Vermicides (Kill helminths)

What are some examples of natural anthelmintic compounds obtained from plant extracts?

Pomegranate, Lemon grass, Ginger, Turmeric, Chamomilla, Wormwood, Basil, Cloves, Black caraway, Thyme, Lemon balm, Mint, Garlic, Cinnamon, Pumpkin seed, Colocynth, Mandarin orange, Lime, Grapefruit, Lemon, Sweet orange, Bitter Orange

Which solvents are particularly effective in extracting phenolic compounds from plants for anthelmintic use?

Polar solvents, such as methanol and ethanol

What is the practical application for anthelmintic plants in terms of preparation of extract?

Preparation of extract involves collecting fresh healthy plants at the peak of their ripeness, accurately identifying the plant, and carefully washing the plant samples with Distilled water to eliminate any contaminants

Which type of anthelmintic drugs expel helminths from the body?

Vermifuges

What method is particularly effective in extracting phenolic compounds from plants for anthelmintic use?

Gas Chromatography-Mass Spectrometry (GC-MS) analysis

Which of the following compounds obtained from plant extracts have anthelmintic effect?

Pumpkin seed

What is the antagonistic relationship between in terms of anthelmintic effect?

Flavonoids and polyphenolic compounds

What is the practical application for anthelmintic plants in terms of preparation of extract?

Fresh healthy plants are collected at the peak of their ripeness

Study Notes

Determining Plant Components for Anthelmintic Effect

  • The components of plants and their proportions are determined through phytochemical analysis and bioassay-guided fractionation
  • This process helps identify the active compounds responsible for the anthelmintic effect

Classification of Anthelmintic Drugs

  • Anthelmintic drugs are roughly divided into two groups: narrow-spectrum and broad-spectrum drugs
  • Narrow-spectrum drugs target specific parasites, while broad-spectrum drugs target multiple parasites

Natural Anthelmintic Compounds from Plant Extracts

  • Examples of natural anthelmintic compounds obtained from plant extracts include:
    • Alkaloids (e.g., piperazine, imidazole)
    • Phenolic compounds (e.g., tannins, flavonoids)
    • Glycosides (e.g., saponins, anthraquinones)

Effective Solvents for Extracting Phenolic Compounds

  • Polar solvents like water, methanol, and ethanol are particularly effective in extracting phenolic compounds from plants for anthelmintic use
  • Other solvents like acetone and dichloromethane may also be used

Practical Application of Anthelmintic Plants

  • The practical application of anthelmintic plants involves preparing extracts through techniques like maceration, decoction, and infusion
  • These extracts can be used to create medicated feed, injectables, or oral medications

Type of Anthelmintic Drugs

  • Vermifuge anthelmintic drugs are those that expel helminths from the body

Effective Method for Extracting Phenolic Compounds

  • The Soxhlet extraction method is particularly effective in extracting phenolic compounds from plants for anthelmintic use
  • This method involves the extraction of a substance with a solvent in a continuous cycle

Compounds with Anthelmintic Effect

  • Compounds obtained from plant extracts with anthelmintic effect include:
    • Tannins
    • Flavonoids
    • Saponins
    • Anthraquinones

Antagonistic Relationship

  • The antagonistic relationship exists between certain anthelmintic compounds, where one compound can reduce the effectiveness of another compound

Test your knowledge on the classification of anthelmintic drugs, including natural compounds obtained from plant extracts. Learn about their effects and the two main groups they are divided into: Vermifuges and Vermicides.

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