8 Questions
Which of the following is an anthracycline used in anticancer therapy?
Doxorubicin
What is one of the goals of combining cytotoxic drugs?
To broaden the extent of cancer cell destruction
Which drug is a camptothecin?
Irinotecan
What is a common adverse effect of antineoplastic drugs?
Gastrointestinal upset
What should be monitored in a patient undergoing antineoplastic therapy?
Loss of appetite
Which of the following drugs are classified as alkylating agents?
Melphalan
Which drug is a platinum analog?
Cisplatin
Which of the following is a common adverse effect related to bone marrow suppression from antineoplastic drugs?
Anemia
Study Notes
Cell Cycle Nonspecific Anticancer Drugs
- Alkylating agents:
- Examples: Busulfan, Cyclophosphamide, Mechlorethamine, Melphalan
- Anthracyclines:
- Examples: Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone
- Antitumor antibiotics:
- Examples: Dactinomycin, Mitomycin
- Camptothecins:
- Examples: Irinotecan, Topotecan
- Platinum analogs:
- Examples: Carboplatin, Cisplatin, Oxaliplatin
Combining Cytotoxic Drugs in Cancer Treatment
- Principles:
- Broaden the extent of cancer cell destruction
- Obtain synergistic effect
- Reduce the duration of chemotherapy
- Minimize adverse effects
Mechanism of Action of Anti-Neoplastic Drugs
- Kill cancer cells, but can also harm healthy cells
- Designed to target a wide range of cells over multiple body systems
- Can have many potential side effects
Common Adverse Effects of Antineoplastic Drugs
- Gastrointestinal upset
- Bone marrow suppression:
- Anemia
- Leukopenia
- Thrombocytopenia
- Alopecia
- Hepatotoxicity
- Impaired wound healing
- Depression of the immune system
- Sterility
- Teratogenicity
Managing a Patient with Antineoplastic Therapy
- Monitor client's sensation of loss of appetite
- Assess for electrolyte imbalance
- Teach client about the cause of the consciousness and muscle cramps
This quiz covers cell cycle nonspecific anticancer drugs, including alkylating agents, anthracyclines, antitumor antibiotics, camptothecins, and platinum analogs. It is designed for Diploma in Nursing Science & Midwifery students.
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