Neuron Pharmacology for Nursing Science & Midwifery

Which of the following is an anthracycline used in anticancer therapy?

What is one of the goals of combining cytotoxic drugs?

Which drug is a camptothecin?

What is a common adverse effect of antineoplastic drugs?

What should be monitored in a patient undergoing antineoplastic therapy?

Which of the following drugs are classified as alkylating agents?

Which drug is a platinum analog?

Which of the following is a common adverse effect related to bone marrow suppression from antineoplastic drugs?

Cell Cycle Nonspecific Anticancer Drugs

Alkylating agents:
- Examples: Busulfan, Cyclophosphamide, Mechlorethamine, Melphalan
Anthracyclines:
- Examples: Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone
Antitumor antibiotics:
- Examples: Dactinomycin, Mitomycin
Camptothecins:
- Examples: Irinotecan, Topotecan
Platinum analogs:
- Examples: Carboplatin, Cisplatin, Oxaliplatin

Combining Cytotoxic Drugs in Cancer Treatment

Principles:
- Broaden the extent of cancer cell destruction
- Obtain synergistic effect
- Reduce the duration of chemotherapy
- Minimize adverse effects

Mechanism of Action of Anti-Neoplastic Drugs

Kill cancer cells, but can also harm healthy cells
Designed to target a wide range of cells over multiple body systems
Can have many potential side effects

Common Adverse Effects of Antineoplastic Drugs

Gastrointestinal upset
Bone marrow suppression:
- Anemia
- Leukopenia
- Thrombocytopenia
Alopecia
Hepatotoxicity
Impaired wound healing
Depression of the immune system
Sterility
Teratogenicity

Managing a Patient with Antineoplastic Therapy

Monitor client's sensation of loss of appetite
Assess for electrolyte imbalance
Teach client about the cause of the consciousness and muscle cramps

This quiz covers cell cycle nonspecific anticancer drugs, including alkylating agents, anthracyclines, antitumor antibiotics, camptothecins, and platinum analogs. It is designed for Diploma in Nursing Science & Midwifery students.