Antacids: Mechanism, Ingredients, Side Effects, and Interactions Quiz

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Questions and Answers

Which active ingredient is commonly found in TUMS?

Calcium carbonate (correct)

Aluminum hydroxide

Magnesium trisilicate

Sodium bicarbonate

How do antacids work in the stomach?

By inducing hyperacidity

By raising the gastric pH and neutralizing acid (correct)

By increasing the acidity of the stomach

By reducing the rate of absorption of concurrently administered drugs

What is the primary purpose of antacids?

To enhance the absorption of concurrently administered drugs

To lower the gastric pH

To provide relief from heartburn and acid indigestion (correct)

To increase the acidity of the stomach

What is the main effect of antacids on concurrently administered drugs?

Enhancing their absorption Signup and view all the answers

Which type of antacid is found in Gaviscon chewable tablets?

Magnesium trisilicate Signup and view all the answers

What are the common forms in which antacids are available?

Powder, tablets, or liquids Signup and view all the answers

What is a common side effect associated with antacids containing magnesium?

Diarrhea Signup and view all the answers

In patients with renal or hepatic impairment, antacids can potentially cause interactions with which type of medications?

Acidic drugs Signup and view all the answers

What is the potential effect of antacids containing magnesium trisilicate and magnesium hydroxide on tetracycline and fluoroquinolone antibiotics?

Reducing their blood concentrations Signup and view all the answers

What is an essential precaution to take before using antacids, especially for individuals who are pregnant or planning to become pregnant?

Consulting with a healthcare provider Signup and view all the answers

What is the primary function of antacids?

Neutralizing stomach acid Signup and view all the answers

Which side effect is associated with antacids containing calcium or aluminum?

Constipation Signup and view all the answers

What should individuals do regarding their current medications and supplements before using antacids?

Inform their healthcare provider Signup and view all the answers

What can antacids containing sodium bicarbonate potentially cause?

Alkalosis Signup and view all the answers

What should individuals always follow before taking antacids?

Dosage instructions on the label Signup and view all the answers

Which group of people should especially consult with a healthcare professional before using antacids?

Individuals with renal or hepatic impairment Signup and view all the answers

Study Notes

Antacids: Types, Mechanism of Action, Common Ingredients, Side Effects, and Interactions with Other Medications

Antacids are over-the-counter medications used to provide symptomatic relief from heartburn, hyperacidity, acid indigestion, GERD, and upset stomach associated with these conditions. They come in various forms, such as powder, tablets, or liquids, and contain salts of magnesium, aluminum, calcium, sodium, carbon, or bismuth as their active ingredients. The most common ingredients include calcium carbonate, sodium bicarbonate, and magnesium trisilicate.

Types of Antacids

Antacids can be classified into several categories based on their active ingredients:

Calcium Carbonate: Found in products like TUMS.
Sodium Bicarbonate: Found in Alka-Seltzer effervescent products.
Magnesium Trisilicate: Found in Gaviscon chewable tablets.
Aluminum Hydroxide: Found in some antacids.

Mechanism of Action

Antacids work by neutralizing the acid in the stomach, raising the gastric pH. They can influence the rate and/or extent of absorption of concurrently administered drugs with pH-dependent stability or pH-dependent solubility. The combination of two salts, such as magnesium and aluminum, form the principal composition of most antacids.

Common Side Effects

Some common side effects associated with antacids include:

Diarrhea (with antacids containing magnesium)
Constipation (with antacids containing calcium or aluminum)
Inhibited bone mineralization (with excessive aluminum intake)
Fluid retention or alkalosis (with antacids containing sodium bicarbonate)

Interactions with Other Medications

Antacids can potentially cause drug-drug interactions, especially in patients with comorbidities such as renal or hepatic impairment. They can impede the absorption of acidic drugs (e.g., digoxin, chlorpromazine, isoniazid) by binding to them, reducing blood concentrations, and impairing their therapeutic effects. Additionally, antacids containing magnesium trisilicate and magnesium hydroxide can bind to drugs like tetracycline and fluoroquinolone antibiotics, impeding their absorption and therapeutic effects.

Precautions and Warnings

It is essential to follow the dosage instructions on the label and consult with a healthcare provider before taking antacids, especially if you are pregnant or planning to become pregnant. Be aware of potential interactions with other medications, and always inform your healthcare provider of any current medications and supplements you are taking.

In conclusion, antacids are commonly used to relieve symptoms of heartburn, indigestion, and other acid-related conditions. They work by neutralizing stomach acid and can interact with other medications, so it is crucial to consult with a healthcare professional before using them. Always follow the dosage instructions on the label and be aware of potential side effects and interactions.

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Description

Test your knowledge about antacids, including their types, mechanism of action, common ingredients, side effects, and interactions with other medications. Learn about the classifications of antacids based on active ingredients and precautions for usage.