Antacids and Anti-secretory Drugs Quiz
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Antacids and Anti-secretory Drugs Quiz

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Questions and Answers

What is the main aim of drug therapy for peptic ulcer?

  • Increase acid production
  • Cause gastric cancer
  • Promote healing (correct)
  • Induce bleeding

    • Which of the following is NOT considered an aggressive factor in the pathophysiology of peptic ulcer diseases?

  • Acid
  • Mucus (correct)
  • Pepsin
  • H. pylori

    • What is the main function of Antacids in drug therapy for peptic ulcer?

  • Cause gastric cancer
  • Neutralize secreted acid (correct)
  • Promote healing
  • Increase acid secretion

    • What is the primary cause of Peptic Ulcer Disease (PUD) according to the text?

    <p>Genetics</p> Signup and view all the answers

    Which of the following is a common symptom of peptic ulcer disease?

    <p>Dark stool indicating bleeding</p> Signup and view all the answers

    What is the role of prostaglandins in the pathophysiology of peptic ulcer diseases?

    <p>Protect the stomach lining</p> Signup and view all the answers

    What is the mechanism of action of antacids?

    <p>Neutralize free acid in the stomach</p> Signup and view all the answers

    How is infection with H. pylori typically treated?

    <p>With antibiotics plus antisecretory drugs</p> Signup and view all the answers

    What is the therapeutic use of antacids?

    <p>Offering symptomatic relief for PUD or GERD</p> Signup and view all the answers

    Which drug category is used to treat inadequate mucosal defense against HCl?

    <p>Mucosal Protectives</p> Signup and view all the answers

    What is the role of antibiotics in the treatment of peptic ulcers?

    <p>Treat infection with H. pylori</p> Signup and view all the answers

    When should antacids be dosed in relation to other medications?

    <p>3 hours before taking other medications</p> Signup and view all the answers

    What is a common side effect associated with aluminum salts?

    <p>Constipation</p> Signup and view all the answers

    Which drug class can lead to gynecomastia and galactorrhea as side effects?

    <p>H2 receptor antagonists</p> Signup and view all the answers

    How can most drug interactions be avoided when taking antacids?

    <p>Taking antacids 2 hours before or after other drugs</p> Signup and view all the answers

    Which H2 receptor antagonist is known to be the most potent?

    <p>Famotidine</p> Signup and view all the answers

    What is the mechanism of action of H2 receptor antagonists on parietal cells?

    <p>Competitive blocker of Histamine H2-receptors</p> Signup and view all the answers

    What is the mechanism of action of Proton Pump Inhibitors (PPIs)?

    <p>Bind covalently to proton pumps</p> Signup and view all the answers

    Which drug class inhibits the fasting secretion of HC1 by 60-70% during the daytime and 90% during the nighttime?

    <p>H2 receptor antagonists</p> Signup and view all the answers

    Which side effect is associated with PPIs use?

    <p>Increased risk of osteoporosis</p> Signup and view all the answers

    What is the role of Mucosal Protective Agents like Bismuth subsalicylate?

    <p>Form a protective layer over ulcer base</p> Signup and view all the answers

    How do Proton Pump Inhibitors affect vitamin B12 absorption?

    <p>Decrease absorption by inhibiting intrinsic factor</p> Signup and view all the answers

    Why do Proton Pump Inhibitors (PPIs) take 24 hours to start working effectively?

    <p>PPIs bind covalently to proton pumps, which requires time for new pump synthesis</p> Signup and view all the answers

    Which drug interaction can be expected with Omeprazole and Esomeprazole?

    <p>Reduced bioavailability of drugs requiring acidity for absorption</p> Signup and view all the answers

    What is the main mechanism of action of Misoprostol?

    <p>Stimulates local prostaglandin production</p> Signup and view all the answers

    Which drug is contraindicated in pregnancy due to its potential to induce labor?

    <p>Misoprostol</p> Signup and view all the answers

    How does Sucralfate work in the treatment of ulcers?

    <p>Binds to negatively charged proteins in the ulcer base</p> Signup and view all the answers

    What is a common side effect of Bismuth therapy?

    <p>Blackening of the tongue and feces</p> Signup and view all the answers

    Which agent is used for the prevention of stress ulcers?

    <p>Sucralfate</p> Signup and view all the answers

    Which antibiotics are effective against H. pylori in combination therapy?

    <p>Metronidazole and Amoxicillin</p> Signup and view all the answers

    Study Notes

    Peptic Ulcer Disease

    • Peptic ulcer disease results from an imbalance between aggressive and defensive mechanisms in the gastric and duodenal mucosa.

    Secretion of HCl

    • Parietal cells produce HCl, which is stimulated by acetylcholine, histamine, and gastrin.
    • H+/K+ ATPase, a proton pump, is responsible for secreting H+ ions into the gastric lumen.

    Pathophysiology of Peptic Ulcer

    • Aggressive factors: acid, pepsin, H. pylori, and NSAIDs.
    • Defensive factors: mucus, bicarbonate, prostaglandins, and mucosal blood flow.

    Clinical Features and Complications

    • Epigastric pain, nausea, vomiting, heartburn, loss of appetite, and dark stools.
    • Bleeding, perforation, gastric outlet obstruction, and gastric cancer are complications.

    Drug Therapy of Peptic Ulcer

    • Four main approaches:
      1. Reduction of gastric acid secretion (anti-secretory drugs).
      2. Mucosal protective agents.
      3. Antimicrobial treatment for eradication of H. pylori.
      4. Neutralization of secreted acid (antacids).

    Anti-Secretory Drugs

    • Proton pump inhibitors (PPIs): omeprazole, pantoprazole.
    • H2 blockers: cimetidine, ranitidine.
    • Mechanism of action: competitive blocker of histamine H2-receptors on parietal cells.

    Antacids

    • Mechanism of action: neutralize free acid in the stomach.
    • Examples: aluminum hydroxide, calcium carbonate.
    • Side effects: constipation vs. diarrhea.

    Mucosal Protective Agents

    • Examples: misoprostol, sucralfate, bismuth subsalicylate.
    • Mechanism of action: stimulate mucus and bicarbonate secretion, enhance mucosal blood flow.
    • Indications: prevention of mucosal injury, reduction of inflammation, and healing existing ulcers.

    Antimicrobial Treatment for Eradication of H. pylori

    • Triple therapy: one PPI + two antibiotics (e.g., metronidazole, amoxicillin, clarithromycin).
    • Treatment duration: 14 days.

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    Description

    Test your knowledge on antacids and anti-secretory drugs including aluminum salts, magnesium salts, drug interactions, and H2 receptor antagonists. Learn about their mechanisms of action and common side effects.

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