Antacids and Anti-secretory Drugs Quiz

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main aim of drug therapy for peptic ulcer?

Increase acid production

Cause gastric cancer

Promote healing (correct)

Induce bleeding

Which of the following is NOT considered an aggressive factor in the pathophysiology of peptic ulcer diseases?

Acid

Mucus (correct)

Pepsin

H. pylori

What is the main function of Antacids in drug therapy for peptic ulcer?

Cause gastric cancer

Neutralize secreted acid (correct)

Promote healing

Increase acid secretion

What is the primary cause of Peptic Ulcer Disease (PUD) according to the text?

Genetics Signup and view all the answers

Which of the following is a common symptom of peptic ulcer disease?

Dark stool indicating bleeding Signup and view all the answers

What is the role of prostaglandins in the pathophysiology of peptic ulcer diseases?

Protect the stomach lining Signup and view all the answers

What is the mechanism of action of antacids?

Neutralize free acid in the stomach Signup and view all the answers

How is infection with H. pylori typically treated?

With antibiotics plus antisecretory drugs Signup and view all the answers

What is the therapeutic use of antacids?

Offering symptomatic relief for PUD or GERD Signup and view all the answers

Which drug category is used to treat inadequate mucosal defense against HCl?

Mucosal Protectives Signup and view all the answers

What is the role of antibiotics in the treatment of peptic ulcers?

Treat infection with H. pylori Signup and view all the answers

When should antacids be dosed in relation to other medications?

3 hours before taking other medications Signup and view all the answers

What is a common side effect associated with aluminum salts?

Constipation Signup and view all the answers

Which drug class can lead to gynecomastia and galactorrhea as side effects?

H2 receptor antagonists Signup and view all the answers

How can most drug interactions be avoided when taking antacids?

Taking antacids 2 hours before or after other drugs Signup and view all the answers

Which H2 receptor antagonist is known to be the most potent?

Famotidine Signup and view all the answers

What is the mechanism of action of H2 receptor antagonists on parietal cells?

Competitive blocker of Histamine H2-receptors Signup and view all the answers

What is the mechanism of action of Proton Pump Inhibitors (PPIs)?

Bind covalently to proton pumps Signup and view all the answers

Which drug class inhibits the fasting secretion of HC1 by 60-70% during the daytime and 90% during the nighttime?

H2 receptor antagonists Signup and view all the answers

Which side effect is associated with PPIs use?

Increased risk of osteoporosis Signup and view all the answers

What is the role of Mucosal Protective Agents like Bismuth subsalicylate?

Form a protective layer over ulcer base Signup and view all the answers

How do Proton Pump Inhibitors affect vitamin B12 absorption?

Decrease absorption by inhibiting intrinsic factor Signup and view all the answers

Why do Proton Pump Inhibitors (PPIs) take 24 hours to start working effectively?

PPIs bind covalently to proton pumps, which requires time for new pump synthesis Signup and view all the answers

Which drug interaction can be expected with Omeprazole and Esomeprazole?

Reduced bioavailability of drugs requiring acidity for absorption Signup and view all the answers

What is the main mechanism of action of Misoprostol?

Stimulates local prostaglandin production Signup and view all the answers

Which drug is contraindicated in pregnancy due to its potential to induce labor?

Misoprostol Signup and view all the answers

How does Sucralfate work in the treatment of ulcers?

Binds to negatively charged proteins in the ulcer base Signup and view all the answers

What is a common side effect of Bismuth therapy?

Blackening of the tongue and feces Signup and view all the answers

Which agent is used for the prevention of stress ulcers?

Sucralfate Signup and view all the answers

Which antibiotics are effective against H. pylori in combination therapy?

Metronidazole and Amoxicillin Signup and view all the answers

Study Notes

Peptic Ulcer Disease

Peptic ulcer disease results from an imbalance between aggressive and defensive mechanisms in the gastric and duodenal mucosa.

Secretion of HCl

Parietal cells produce HCl, which is stimulated by acetylcholine, histamine, and gastrin.
H+/K+ ATPase, a proton pump, is responsible for secreting H+ ions into the gastric lumen.

Pathophysiology of Peptic Ulcer

Aggressive factors: acid, pepsin, H. pylori, and NSAIDs.
Defensive factors: mucus, bicarbonate, prostaglandins, and mucosal blood flow.

Clinical Features and Complications

Epigastric pain, nausea, vomiting, heartburn, loss of appetite, and dark stools.
Bleeding, perforation, gastric outlet obstruction, and gastric cancer are complications.

Drug Therapy of Peptic Ulcer

Four main approaches:
1. Reduction of gastric acid secretion (anti-secretory drugs).
2. Mucosal protective agents.
3. Antimicrobial treatment for eradication of H. pylori.
4. Neutralization of secreted acid (antacids).

Anti-Secretory Drugs

Proton pump inhibitors (PPIs): omeprazole, pantoprazole.
H2 blockers: cimetidine, ranitidine.
Mechanism of action: competitive blocker of histamine H2-receptors on parietal cells.

Antacids

Mechanism of action: neutralize free acid in the stomach.
Examples: aluminum hydroxide, calcium carbonate.
Side effects: constipation vs. diarrhea.

Mucosal Protective Agents

Examples: misoprostol, sucralfate, bismuth subsalicylate.
Mechanism of action: stimulate mucus and bicarbonate secretion, enhance mucosal blood flow.
Indications: prevention of mucosal injury, reduction of inflammation, and healing existing ulcers.

Antimicrobial Treatment for Eradication of H. pylori

Triple therapy: one PPI + two antibiotics (e.g., metronidazole, amoxicillin, clarithromycin).
Treatment duration: 14 days.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Test your knowledge on antacids and anti-secretory drugs including aluminum salts, magnesium salts, drug interactions, and H2 receptor antagonists. Learn about their mechanisms of action and common side effects.