Animal Studies in Drug Discovery

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Why is proper handling of rodents important in animal studies?

Improper handling can adversely affect experiments.

What is required for animal research protocols in laboratory settings?

Ethics committee approval

What are the two main routes of drug administration for laboratory animals?

Local and systemic (enteral or parenteral)

How does route of administration influence a drug's effect in laboratory animals?

Anatomy, physiology, and biochemistry of route sites are different, impacting drug's effect.

What is one of the factors influencing how much volume can be administered into rodents?

Maximum limit

How can dosage conversion be calculated for different species of animals?

Using body surface area

What formula is used for converting doses based on body surface area?

mg/m2 = km × mg/kg

Explore the significant role of animal studies in drug discovery, focusing on the use of rodents like mice and rats. Learn about the importance of proper handling, ethical considerations, and the impact on experimental outcomes.

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