Animal Studies in Drug Discovery Process
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Questions and Answers

Scruffing the skin on the neck of the mouse helps to prevent it from turning its head and biting your fingers.

True

When administering a drug per orally to a mouse, the needle is inserted into the esophagus.

False

Aspirating the needle during intraperitoneal administration ensures that it is inside the peritoneal cavity.

True

To administer a drug intravenously to a mouse, you insert the needle parallel to the tail vein with the bevel facing downwards.

<p>False</p> Signup and view all the answers

Before injecting a solution into a mouse intravenously, you should warm the tail with a warm towel or warm water to dilate the vessels.

<p>True</p> Signup and view all the answers

How should you restrain a mouse for subcutaneous administration of a drug?

<p>Pinch the skin at the back of the neck with your thumb and forefinger.</p> Signup and view all the answers

What angle should the needle be inserted at for intraperitoneal administration in a mouse?

<p>Around 10 degree angle between the needle and the abdominal surface in the lower quadrant of the abdomen.</p> Signup and view all the answers

Why is it important to aspirate the needle during intraperitoneal administration?

<p>To ensure that the needle is inside the peritoneal cavity.</p> Signup and view all the answers

How should you prepare the mouse for intravenous administration of a drug?

<p>Warm the tail with a warm towel or a lamp to dilate the vessels.</p> Signup and view all the answers

What should you do after injecting a solution intravenously into a mouse?

<p>Retract the needle and press the injection site firmly to prevent backflow of the solution.</p> Signup and view all the answers

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