Animal Science 322: Disease, Health & Management

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Questions and Answers

Which of the following factors is considered a component of immune competence in animals?

  • Breed size
  • Animal vitality (correct)
  • Tail length
  • Coat color

Adaptive capacity in animals refers to the ability to undergo significant changes in their fundamental genetic makeup when faced with a changing environment.

False (B)

Which of the following is most closely associated with the maturation of the chicken mucosal immune system?

  • Maturation of dendritic cells (correct)
  • Increased feather production
  • Limb length
  • Decreased appetite

The hygiene hypothesis suggests that reduced exposure to microbes in early life can lead to an increased susceptibility to ______ diseases.

<p>allergic</p> Signup and view all the answers

Match the following components with their function in neonate protection against pathogens:

<p>Maternal antibodies (IgG, IgA) = Passive immunity Antimicrobial peptides = Innate defense Cytokines (IL-10, TGF-beta, IFNgamma, IL-4) = Immune modulation Monocytes, macrophages = Phagocytosis</p> Signup and view all the answers

In chickens, the intestinal microenvironment is most dynamic during which period post-hatch?

<p>Between 2 and 6 weeks (B)</p> Signup and view all the answers

Dendritic cells, found in both chickens and other species, have different functions across species to accommodate species-specific immune responses.

<p>False (B)</p> Signup and view all the answers

Pattern Recognition Receptors (PRR) like ______ recognize molecular patterns on pathogens.

<p>TLR's</p> Signup and view all the answers

What is the best definition for adaptive capacity?

<p>The ability of an animal to adapt to a changing environment with minimum loss of function. (B)</p> Signup and view all the answers

Which of the following is considered as improving the adaptive capacity of animals?

<p>Selection, development, and facilitation. (A)</p> Signup and view all the answers

Introducing bacteria into germ-free animals always leads to disease due to the underdeveloped immune system.

<p>False (B)</p> Signup and view all the answers

What is the main role of maternal antibodies, like IgG and IgA, in neonates?

<p>Providing passive immunity (D)</p> Signup and view all the answers

Match the cells with their role in the intestinal mucosal immune system:

<p>Epithelial cells = Form a single-layer barrier IgA = Contributes to mucosal homeostasis Dendritic cells = Educated by foreign antigens B cells = Produce antibodies</p> Signup and view all the answers

What type of signals do activated dendritic cells provide for T-helper cell differentiation?

<p>signals</p> Signup and view all the answers

According to the hygiene hypothesis, a completely sterile environment is most beneficial for developing a robust immune system in early childhood.

<p>False (B)</p> Signup and view all the answers

According to the hygiene hypothesis, what could be a consequence of reduced exposure to diverse microbes in early life?

<p>Greater susceptibility to allergic diseases (D)</p> Signup and view all the answers

According to the research, gritty rats and mice living in sewers and farms seem to have ______ immune systems than clean cousins.

<p>healthier</p> Signup and view all the answers

What is the typical weaning age for piglets in commercial pig husbandry?

<p>3-4 weeks (A)</p> Signup and view all the answers

Weaning in pigs typically only involves one major stress factor: the abrupt change from milk to solid feed.

<p>False (B)</p> Signup and view all the answers

Which of the following management strategies may reduce weaning stress in piglets?

<p>Socialising piglets pre-weaning (A)</p> Signup and view all the answers

Name three potential issues of weaning in pigs.

<p>low nutrient intake, belly nosing, decreased growth</p> Signup and view all the answers

Match the following events to if they happen before or at weaning

<p>Feeding behavior = Before Changes in feeding composition = At Digestive tract maturity = Before Villus atrophy = At</p> Signup and view all the answers

What is a key component of pre-weaning solutions aimed at preparing piglets for weaning?

<p>Stimulating feed intake before weaning. (D)</p> Signup and view all the answers

High variation in feed intake between litters is not an important factor for pre- or post-weaning piglet health.

<p>False (B)</p> Signup and view all the answers

The design of the ______ can stimulate exploration behavior during feeding.

<p>feeding trough</p> Signup and view all the answers

Which of the following is an advantage of socialising piglets pre-weaning?

<p>Decreased aggression at weaning. (B)</p> Signup and view all the answers

Which of the following is involved post-weaning problems, but is not the sole initiator?

<p>E Coli (B)</p> Signup and view all the answers

Piglets should be moved to a climate that is the same or similar to the previous climate.

<p>True (A)</p> Signup and view all the answers

Which is not an example of a cascade of events in post-weaning enteric disorders in pigs?

<p>Climate Change (B)</p> Signup and view all the answers

Match the number of days with the description.

<p>40 days = EU organic 49 days = Denmark and Sweden EU organic 21 days = Minimum days for lactation under EU regulations 28 days = Age piglets should be weaned</p> Signup and view all the answers

Name two factors that contribute to post-weaning pig stress.

<p>Mixing litters, different housing</p> Signup and view all the answers

Which of the following accurately describes 'intermittent suckling' in piglets?

<p>Separating the sow and piglets for a fixed period per day (A)</p> Signup and view all the answers

The health of the mother does not have a large role in that of her neonates (piglets).

<p>False (B)</p> Signup and view all the answers

Which method should the diet of piglets be changes?

<p>Gradual (A)</p> Signup and view all the answers

Microbial exposure can increase what aspect in pigs ______?

<p>immunity</p> Signup and view all the answers

Give three examples that would cause weaning challenges in piglets.

<p>Problems with the weaning process, behavioral issues, environmental problems</p> Signup and view all the answers

What is a factor to consider from the 'environmental aspects'?

<p>Before weaning (A)</p> Signup and view all the answers

For T helper cell polarization, Signals from the microenvironment do not direct the response of the dendritic cells.

<p>False (B)</p> Signup and view all the answers

Give two reasons why you would want to wean a piglet.

<p>For slaughter, for show</p> Signup and view all the answers

Match the location to how it affects health

<p>Gut = Colonization Birth = Passive immunity Weaning = Oral tolerance Puberty = Adaptive immunity</p> Signup and view all the answers

Why is hygiene important?

<p>Hygiene may influence immune competence in later life. (C)</p> Signup and view all the answers

Flashcards

Adaptive capacity

The ability of an animal to adapt to a changing environment with minimal loss of function.

Genetic selection

Improving adaptive capacity through deliberate breeding choices for desired traits.

Development

Enhancing adaptive capacity by optimizing animal development.

Facilitation

Improving adaptive capacity by providing an optimal environment.

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Germ-free animals

Animals lacking exposure to diverse microbes have underdeveloped immune systems.

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Neonatal Chicken Immunity

Chicken neonatal immunity relies on maternal antibodies, immune cells, and innate functions because their immune system is immature at hatch.

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Intestinal mucosal immune system

Large surface area with single epithelial layer, high infection risk, complex immunoglobulin components.

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Post-hatch Immunity

Immune system is not active immediately post-hatch; it develops over weeks.

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Mucosal Dendritic Cells

These cells sample antigens, expose them to immune cells, and direct the immune response.

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Pattern Recognition Receptors (PRR)

Pattern Recognition Receptors recognize molecular patterns from pathogens, triggering immune responses.

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T Helper Cell Responses

Early life infections shape T helper cell responses, directing the immune system long term.

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Hygiene Hypothesis

Limited diversity in microbial exposure could lead to an increased risk of allergies and immune disorders.

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Pig weaning

Weaning at 3-4 weeks induce numerous problems.

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Stress on piglets after weaning

Being away from their moms, different housing, new mixes of animals and foods all cause stress and make weaning difficult for piglets.

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Piglet behavior during weaning

The piglets show of distress (vocalization), manipulativeness, anorexia and slower growth.

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Piglet problems during weaning

Weaning causes several issues in the pig gut.

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Pre-weaning factor on piglets

Some factors related to feed, age, and weight.

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Make smart Pre-weaning Choices

One way to make sure they're healthy later is by feeding quality pre-weaning food.

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Stimulate Feed Intake

Get piglets used to new food, nipple type water

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Weaning Management

Good age and weight means less sorting

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Socializing piglets pre-weaning

Mixing helps prepare piglets for new life and change

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During lactation, add trough design

Use exploration and good feed

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Intermittenet suckling

If piglets adapt to new feed, they'll have way less stress.

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Study Notes

Course Information

  • The course is Animal Science 322 for Livestock and Poultry Diseases
  • The instructor is Dr Lourdes V. Icalla, Associate Professor, Mindora State University

Major Topics for Midterm AS 207

  • These topics include introduction to disease, health, welfare, and management
  • Also include notifiable diseases

Introduction

  • Introduces topic to MSC 207
  • Discusses emerging diseases in Asia and the Pacific
  • Discusses emerging infectious diseases WHO
  • Covers the current status of important transboundary diseases
  • Goes over One Health Approach OIE Diseases

Health vs Disease

  • Gives an overview of the immune system
  • Describes Animal Disease Prevention and Control

Health Welfare and Management

  • Covers immune competence and animal vitality
  • Focuses on Chicken Vitality and Chicken Competence (Decuypere, 2001)
  • Describes Pig Vitality (Brisbin, 2008; Clavijo & Vives Fl´orez, 2017)

Hygiene Hypothesis

  • The hygiene hypothesis considers Diversity of microbiota
  • Early life infections are an important consideration
  • Endotoxins or lipopolysaccharides are also an important consideration

Pig Vitality

  • Weaning in nature happens between 10 - 16 weeks of age
  • It is a gradual transition from milk to dry feed
  • Includes learning from the mother and adaptation and maturation of the gastrointestinal tract from a variety of feed sources

How to optimize the weaning process

  • An optimized process covers weaning of pigs and associated problems
  • “Environmental” aspects must be taken into account
  • Preparation of piglets is essential before weaning
  • Development of feed intake behavior is vital

Weaning in pig husbandry

  • This happens usually at 3-4 weeks of age
  • EU regulations stipulate lactation should be at least 3 to 4 weeks given there are problems
  • Organic EU is roughly 6 weeks/40 days

“Stress” factors during weaning

  • Consists of being away from the sow and different housing for pigs
  • It also includes mixing of litters, abrupt change from milk to dry feed

Associated signs of distress with low level weaning

  • They cause the high frequency of calls that are greater than 500 Hz
  • Diets that contain high complexity reduce the amount of distress calls

Decreased piglet growth

  • A reduced piglet growth or even eventual weight loss is directly associated
  • Manipulative behaviour, belly nosing and decrease in intestinal function resulting in dirrhoea is an indicator

Cascade of events in post weaning enteric disorders in pigs

  • Digestive tract maturity occurs prior to weaning
  • There can be changes in feeding composition level and changes in digestive tract microflora
  • Environmental conditions includes climate, hygiene, feeding

Environmental conditions

  • Also include the management, that is, the weaning age and digestive efficacy reduction
  • This is alongside non digested food which can cause increase of bacteria population

The Role of E. Coli

  • Produce factors that damage the intestines
  • It is involved in the post-weaning problems, however, it is not the sole initiator

E.Coli facts

  • Inoculation causes ~50% diarrhea
  • Can lead to diarrhea and mortality, in the case of pre-treating antibiotics, PLUS TGE-virus
  • Can be a no-diarrhoea (Wathes, 1989)

Post Weaning Enteric Disorders

  • Should occur only with all-in/out + dry floor + clean and warm (<24C)
  • Can occur with NH3<10ppm, CO2<0.15%, air speed<0.1m/s, no draught, RH>85% (humidity) environment in post weaning
  • Pig Feed (pre/post wean) can cause the disorder Health/Hygiene, and Climate

Pre-Weaning Factors

  • Factors include feed intake, age, and weight at weaning
  • Environment post-weaning and appropriate feeding behavior is important

Pre-Wean solutions

  • Solutions often stimulate feed intake
  • Often is a Creep feed which should taste, smell, and appear attractive
  • There is often need to stimulate drinking behaviour with a bowler or nipple type feature

Weaning management

  • Weaning management considers age, weight and avoids mixing of litters
  • Socialising piglets pre-weaning is essential

Piglet feed solutions

  • High variation in feed intake between and within litters
  • During lactation, it is generally quite low
  • This can involve a feeding trough design using something to stimulate exploration

Reducing stress from socialization of piglets

  • Mixing piglets at weaning causes and aggression
  • This reduces feed intake and welfare
  • "Might reduce stress at weaning and thereby affect post-weaning behaviour and performance"
  • There tends to be more post-wean fighting which is more dependent on age

Improving feed intake

  • May consist of Intermittent suckling that involves a separation of sow and piglets during a fixed period per day
  • This should be a continuous presence sow and be intermittent during lactation and weaning

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