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Questions and Answers
What does proximate causation focus on in physiological processes?
What does proximate causation focus on in physiological processes?
In the context of muscle contraction, what does ultimate causation explain?
In the context of muscle contraction, what does ultimate causation explain?
What is the primary difference between basic and applied physiology?
What is the primary difference between basic and applied physiology?
How does potential energy relate to animal physiology?
How does potential energy relate to animal physiology?
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What is the overarching goal of the course described?
What is the overarching goal of the course described?
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What is one example of how applied physiology can benefit society?
What is one example of how applied physiology can benefit society?
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What is potential energy also associated with in cellular physiology?
What is potential energy also associated with in cellular physiology?
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Which aspect is NOT included in the scope of the course?
Which aspect is NOT included in the scope of the course?
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At which level of analysis would researchers investigate the hormones regulating reproduction?
At which level of analysis would researchers investigate the hormones regulating reproduction?
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Which chromosome's presence primarily dictates the development of male reproductive organs in mammals?
Which chromosome's presence primarily dictates the development of male reproductive organs in mammals?
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What is a primary impact of endocrine disruptors on animal reproduction?
What is a primary impact of endocrine disruptors on animal reproduction?
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Which of the following hypotheses suggests that sleep helps in energy restoration?
Which of the following hypotheses suggests that sleep helps in energy restoration?
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What key stage of sleep is associated with memory consolidation?
What key stage of sleep is associated with memory consolidation?
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What is a major challenge in studying the effects of endocrine disruptors?
What is a major challenge in studying the effects of endocrine disruptors?
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Which of the following is a function of sleep during the REM stage?
Which of the following is a function of sleep during the REM stage?
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Which method is commonly used to study brain activity during different stages of sleep?
Which method is commonly used to study brain activity during different stages of sleep?
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What effect can plastic, as an endocrine disruptor, have on animal reproductive systems?
What effect can plastic, as an endocrine disruptor, have on animal reproductive systems?
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Which hormone is primarily responsible for the development of female secondary sexual characteristics?
Which hormone is primarily responsible for the development of female secondary sexual characteristics?
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What adaptation allows high-altitude birds like bar-headed geese to effectively capture oxygen?
What adaptation allows high-altitude birds like bar-headed geese to effectively capture oxygen?
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How do respiratory systems minimize energy use while maximizing gas exchange?
How do respiratory systems minimize energy use while maximizing gas exchange?
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What is the primary function of countercurrent exchange in physiological systems?
What is the primary function of countercurrent exchange in physiological systems?
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Which fluid compartment is responsible for fluid balance outside the cells?
Which fluid compartment is responsible for fluid balance outside the cells?
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What strategy do freshwater fish use to deal with external dilution?
What strategy do freshwater fish use to deal with external dilution?
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What type of waste is typically excreted in a more concentrated form by birds and reptiles?
What type of waste is typically excreted in a more concentrated form by birds and reptiles?
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Which component of the kidney is primarily responsible for filtering blood?
Which component of the kidney is primarily responsible for filtering blood?
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How do hormones achieve specificity in their actions throughout the body?
How do hormones achieve specificity in their actions throughout the body?
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What role do negative feedback loops play in homeostasis?
What role do negative feedback loops play in homeostasis?
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Which organism is most likely to have straightforward regulatory systems due to stable environments?
Which organism is most likely to have straightforward regulatory systems due to stable environments?
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Which physiological adaptation do salmon use when transitioning from freshwater to saltwater?
Which physiological adaptation do salmon use when transitioning from freshwater to saltwater?
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What is the primary purpose of the nephron's countercurrent exchange mechanism?
What is the primary purpose of the nephron's countercurrent exchange mechanism?
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Which type of feedback mechanism is primarily involved in processes like childbirth?
Which type of feedback mechanism is primarily involved in processes like childbirth?
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How do the structures of the renal glomeruli relate to kidney function?
How do the structures of the renal glomeruli relate to kidney function?
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What role does the renin-angiotensin-aldosterone system play in mammalian physiology?
What role does the renin-angiotensin-aldosterone system play in mammalian physiology?
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What is the relationship between metabolic rate and body size in animals?
What is the relationship between metabolic rate and body size in animals?
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How do ectotherms manage their metabolic rate concerning environmental temperature?
How do ectotherms manage their metabolic rate concerning environmental temperature?
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Which adaptation allows camels to thrive in desert environments?
Which adaptation allows camels to thrive in desert environments?
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What does the heat balance equation describe?
What does the heat balance equation describe?
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Performance curves help to understand which of the following?
Performance curves help to understand which of the following?
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How do tropical species typically react to slight temperature changes?
How do tropical species typically react to slight temperature changes?
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What characterizes a sensory transducer?
What characterizes a sensory transducer?
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What occurs when a receptor potential reaches a certain threshold?
What occurs when a receptor potential reaches a certain threshold?
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What does shivering do in cold environments?
What does shivering do in cold environments?
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What happens in the pejus temperature range for organisms?
What happens in the pejus temperature range for organisms?
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What physiological feature supports water conservation in camels?
What physiological feature supports water conservation in camels?
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What adaptive mechanism do endotherms employ to manage heat in warm environments?
What adaptive mechanism do endotherms employ to manage heat in warm environments?
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What is one effect of global climate change specifically on temperate species?
What is one effect of global climate change specifically on temperate species?
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What occurs during isometric contractions?
What occurs during isometric contractions?
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Which metabolic process is primarily used for short bursts of intense activity?
Which metabolic process is primarily used for short bursts of intense activity?
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What is muscle hypertrophy?
What is muscle hypertrophy?
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How do fast-twitch muscle fibers differ from slow-twitch fibers?
How do fast-twitch muscle fibers differ from slow-twitch fibers?
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What mechanism do animals use to improve muscle power during movement?
What mechanism do animals use to improve muscle power during movement?
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What is the primary purpose of valves in a closed circulatory system?
What is the primary purpose of valves in a closed circulatory system?
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What is the primary role of the ear in detecting sound?
What is the primary role of the ear in detecting sound?
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How does a two-chambered heart differ functionally from a four-chambered heart?
How does a two-chambered heart differ functionally from a four-chambered heart?
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Which structure of the ear is responsible for balance?
Which structure of the ear is responsible for balance?
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What is the significance of partial pressure in gas exchange?
What is the significance of partial pressure in gas exchange?
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How does the body respond to acute stress?
How does the body respond to acute stress?
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Which hormone is primarily released during the stress response?
Which hormone is primarily released during the stress response?
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How do respiratory pigments like hemoglobin assist in gas transport?
How do respiratory pigments like hemoglobin assist in gas transport?
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How does solubility influence gas concentrations in blood?
How does solubility influence gas concentrations in blood?
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What is the effect of chronic stress on the immune system?
What is the effect of chronic stress on the immune system?
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What is a common method for studying ear function in research?
What is a common method for studying ear function in research?
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What adaptation helps animals manage fatigue during prolonged exercise?
What adaptation helps animals manage fatigue during prolonged exercise?
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What effect does the Bohr effect have on hemoglobin's function?
What effect does the Bohr effect have on hemoglobin's function?
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What are tympanal organs primarily used for in some invertebrate species?
What are tympanal organs primarily used for in some invertebrate species?
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Which of the following is a major stressor for wild animals?
Which of the following is a major stressor for wild animals?
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How do adaptations in circulatory systems reflect evolutionary diversity?
How do adaptations in circulatory systems reflect evolutionary diversity?
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In wild animals, how can stress manifest physiologically?
In wild animals, how can stress manifest physiologically?
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What is the main function of the otolith organs in the ear?
What is the main function of the otolith organs in the ear?
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What is one method of experimental analysis used in studying stress in wild animals?
What is one method of experimental analysis used in studying stress in wild animals?
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How do the outer, middle, and inner ear sections function together?
How do the outer, middle, and inner ear sections function together?
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What role does the HPA axis play in stress response?
What role does the HPA axis play in stress response?
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Which sensory input is primarily linked to the auditory system?
Which sensory input is primarily linked to the auditory system?
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What is the primary function of the sodium-potassium pump?
What is the primary function of the sodium-potassium pump?
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Which process combines to improve water and nutrient absorption in the intestines during diarrheal disease treatment?
Which process combines to improve water and nutrient absorption in the intestines during diarrheal disease treatment?
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What role do ion channels play in the function of neurons?
What role do ion channels play in the function of neurons?
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How did the evolution of neurons contribute to communication in multicellular organisms?
How did the evolution of neurons contribute to communication in multicellular organisms?
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What distinguishes the role of the dendrites in neuron function?
What distinguishes the role of the dendrites in neuron function?
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What is the primary consequence of synaptic plasticity?
What is the primary consequence of synaptic plasticity?
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Which of the following describes isotonic muscle contractions?
Which of the following describes isotonic muscle contractions?
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What is a key feature of the lipid bilayer in cell membranes?
What is a key feature of the lipid bilayer in cell membranes?
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How do calcium ions affect muscle contractions?
How do calcium ions affect muscle contractions?
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What primary mechanism explains how neurons transmit electrical signals?
What primary mechanism explains how neurons transmit electrical signals?
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What is the major role of the cerebellum in the brain?
What is the major role of the cerebellum in the brain?
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What advantage do model organisms like mice and zebrafish provide in neurological research?
What advantage do model organisms like mice and zebrafish provide in neurological research?
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What distinguishes active transport from facilitated diffusion?
What distinguishes active transport from facilitated diffusion?
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What is the function of neurotransmitters at synapses?
What is the function of neurotransmitters at synapses?
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Study Notes
Proximate vs. Ultimate Causation
- Proximate causation explains how a physiological process occurs, focusing on immediate mechanisms like molecular and cellular processes.
- Ultimate causation explains why a process evolved, considering its adaptive value for survival and reproduction.
- Example: In muscle contraction, proximate causation involves calcium ions, while ultimate causation explores the evolutionary advantage of movement.
Basic and Applied Physiology
- Basic physiology investigates fundamental biological processes, such as organ function and cellular responses.
- Applied physiology uses this knowledge to address practical problems, like improving health, enhancing animal husbandry, or developing treatments.
- Example: Studying heart failure mechanisms to develop better treatments illustrates the connection.
Course Goals and Framework
- Course goal: Explore physiological adaptations across species, including human adaptations.
- Scope: Broad, encompassing molecular to whole organism physiology (from cellular mechanisms to ecological impacts).
- Framework: Integrates theory with real-world applications through case studies and experimental research.
Energy and Flow
- Potential energy: Stored energy in molecules (like glucose, fats) and electrochemical gradients (ion gradients).
- Cellular level: Potential energy in ATP powers cell processes; electrochemical gradients fuel action potentials.
- Cell membranes: Selectively permeable, with proteins governing gradients. The sodium-potassium pump establishes gradients for nerve impulses.
Essential Membrane Components
- Selective permeability: Cell membranes control what enters and exits.
- Proteins (ion channels, pumps, carriers): Key to creating and maintaining electrochemical gradients.
- Lipid bilayer: Forms the membrane's basic structure, controlling passage.
Diarrheal Disease Treatment
- Osmosis: Water movement across membranes from low to high solute concentration.
- Active transport: Energy-dependent movement against concentration gradients (e.g., Na+/K+ pump).
- Secondary active transport: Using ion gradients (e.g., sodium) to move other molecules (e.g., glucose absorption).
- Oral rehydration therapy (ORT) leverages osmosis and secondary active transport to improve water and nutrient absorption in diarrheal diseases.
Electrical Beings
- Neural signaling: Neurons transmit signals via electrical impulses, analogous to electrical wires.
- Neuronal components: Dendrites receive signals; cell body processes them; axon transmits signals; synapses transmit between neurons.
- Ion channels: Allow ion flow to create action potentials. Neurotransmitters facilitate signal transmission.
Neuron Evolution
- Early neurons: Evolved from simple cell signaling in single-celled organisms.
- Specialization: Evolved for complex communication; electrical synapses for faster signal transmission.
Synapses and Brains
- Brain structure and function: Varies across species, from ganglia in simple organisms to specialized regions in mammals.
- Synapse function: Variable and precise control through neurotransmitter release.
- Model systems: Fruit flies, mice, and zebrafish are frequently used for studying the nervous system due to their genetics, accessible nervous systems, and ease of manipulation.
Muscle Building Blocks
- Muscle proteins: Actin and myosin are key for movement via sliding-filament model. ATP powers myosin movement.
- Movement variability: Controlled by varying protein concentration, arrangement, and calcium ion concentration in the Sarcoplasmic Reticulum.
Muscle Permeability and Ion Concentration
- Membrane permeability (Na+, Ca2+): Crucial for muscle contractions as signals trigger calcium release.
- Ion concentration gradients: Established by ion pumps (Na+/K+ pump) to generate necessary action potential charges.
Muscle Performance
- Isotonic contraction: Muscle shortens or lengthens with constant tension (e.g., lifting).
- Isometric contraction: Generates force without length change (e.g., pushing).
- Force-speed tradeoff: Muscles can generate high force (slow) or move quickly (low force).
- Energy supplies: Muscles use ATP; anaerobic (short bursts) and aerobic (long-term) respiration.
- Muscle recovery and adaptation: Increased muscle size (hypertrophy) and adaptation over time.
Powerful Movement
- Power maximization: Force-velocity relationship (sacrificing force for speed or greater force for slower movements).
- Lever systems: Limb structures enhance muscle force.
- Muscle fiber types: Fast-twitch (high force, short bursts) and slow-twitch (efficient, long-duration).
Circumventing Muscle Limitations
- Mechanical systems: Tendons, levers amplify muscle force.
- Elastic energy storage: In tendons (e.g., animals like kangaroos).
Therapeutic Techniques
- Eccentric training: Increases tendon stiffness and efficiency.
- Prosthetics and exoskeletons: Enhance muscle-tendon efficiency.
Pumps and Tubes
- Circulatory systems: Small-scale flow (capillary exchange) connected to large-scale flow (heart-driven circulation).
- Factors influencing circulatory systems: Size, environment, metabolic needs influence the type of circulatory systems (open vs. closed).
- Evolution of hearts: Reflects needs for efficient nutrient distribution.
Gas Exchange
- Partial pressure and solubility: Determine oxygen and carbon dioxide concentrations in blood.
- Respiratory pigments: Increase oxygen-carrying capacity (e.g., hemoglobin).
- Oxygen affinity variation: Species in low-oxygen environments have higher affinity.
Respiratory Systems
- Energy efficiency in respiration: Systems are designed for minimal energy expenditure while maximizing gas exchange.
- Countercurrent exchange: Maximizes gas exchange (e.g., in fish gills).
- Bird adaptations at high altitudes: High-affinity hemoglobin and unidirectional air flow maximize oxygen uptake.
Water Balance and Homeostasis
- Internal fluid compartments: Intracellular (ICF) and extracellular (ECF).
- Homeostatic regulation: Variations in different environments (e.g., freshwater vs. saltwater fish).
- Salmon adaptation: Physiologically switch between fresh and saltwater environments.
Excretion and Kidneys
- Strategies for waste removal (ammonia, urea, uric acid).
- Kidney function: Filtering blood, regulating water, salt, pH, excreting waste.
- Nephrons: Filter blood, reabsorb vital substances, and secrete waste. Countercurrent exchange in the nephron.
Kidney Transplants
- Building transplants: Mimicking kidney function; matching structure, vascular connections, and tissue compatibility.
- Research on artificial kidneys and dialysis.
Feedback, Endocrine System, and Kidney
- Feedback mechanisms: Negative feedback for homeostasis; positive feedback (e.g., childbirth).
- Hormone specificity: Hormones interact with specific receptors on target cells.
- Kidney feedback mechanisms: Renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and sodium.
Metabolism
- Metabolism: Sum of all chemical reactions in an organism.
- Metabolic rate measurement: Calorimetry or oxygen consumption.
- Metabolic rate and body size: Larger animals generally have higher overall metabolic rates, while smaller animals have higher rates per unit mass.
Temperature Physiology
- Knut Schmidt-Nielsen contributions: Comparative physiology, animal thermoregulation, and the heat balance equation.
- Desert-tolerant camels: Adaptations for tolerating extreme temperatures and conserving water.
- Heat balance equation: Accounts for radiation, convection, conduction, and evaporation to regulate temperature.
Temperature Physiology and Climate Change
- Performance curves: Show how performance varies with temperature.
- Thermal optimal ranges: Ideal temperatures for peak performance, with declines at both extremes.
- Pejus and critical temperature ranges: Reduced performance or survival at extreme temperatures.
- Effects of global climate change: Implications for species in tropical vs. temperate zones.
Sensory Systems as Transducers
- Sensory transducers: Biological systems converting stimuli into electrical signals.
- Engineered transducers comparison.
- Stimulus to neural signal: Receptor potential triggers action potentials.
- Sensory systems study methods: Electrophysiology, behavioral assays, imaging.
- Applications in human products: Prosthetic development, assistive technologies, sensory-based robotics.
Ears
- Ear function: Detection of sound and balance.
- Ear structure: Vertebrate ears (outer, middle, inner) and invertebrate variations.
- Signal transduction: Sound vibrations converted into electrical signals.
- Balance and equilibrium: Semicircular canals and otolith organs.
- Study methods: Auditory brainstem response (ABR), postural sway tests, imaging.
Stress
- Stress definition: Body's response to threats/challenges.
- Endocrine, nervous, and immune responses: HPA axis, sympathetic nervous system, immune modulation.
- Short-term vs. long-term stress outcomes: Adaptive vs. detrimental effects.
Stress Research in an Ecological Context
- Stress in wild animals: Response to environmental challenges, affecting behavior and fitness.
- Experimental stress studies: Exposures, physiological measurements, field studies.
- Major stressors in wild animals: Predation, resources, environmental disturbances, manifested through behavior and physiology.
Reproduction and Endocrine Disruptors
- Levels of analysis for reproductive systems: Molecular to whole organism.
- Mammalian reproductive development: Influenced by genes, hormones (testosterone, estrogen).
- Endocrine disruptors: Chemicals interfering with hormones, causing reproductive problems.
- Major challenges in studying/assessing: Species sensitivity differences, subtle effects, long-term impacts.
Sleep
- Sleep definition: Reversible state of reduced consciousness, essential for brain and body recovery.
- Sleep stages: REM and non-REM sleep stages.
- Hypotheses for sleep: Restoration, memory consolidation, evolutionary.
- Testing hypotheses: Neuroimaging, sleep deprivation/manipulation experiments, sleep disorders.
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Description
Test your understanding of key concepts in animal physiology, including proximate and ultimate causation, energy relationships in muscle contraction, and the distinctions between basic and applied physiology. Explore how these physiological principles relate to societal benefits and the scope of the field.