Podcast
Questions and Answers
What are some possible consequences of an animal being mismatched with its environment?
What are some possible consequences of an animal being mismatched with its environment?
- Increased stress, leading to a higher risk of disease (correct)
- Improved overall health and well-being
- No significant impact on the animal's health
- Increased productivity and output
What are some examples of management practices that can be used to minimize animal stress and maximize stress resilience?
What are some examples of management practices that can be used to minimize animal stress and maximize stress resilience?
- Providing adequate shelter and nutrition
- Reducing overcrowding and providing enrichment
- Implementing humane handling practices
- All of the above (correct)
What are the two main stress axes involved in the physiological stress response?
What are the two main stress axes involved in the physiological stress response?
- Sympathetic-adrenal-medullary (SAM) axis and hypothalamic-pituitary-thyroid (HPT) axis
- Parasympathetic-adrenal-medullary (PAM) axis and hypothalamic-pituitary-thyroid (HPT) axis
- Parasympathetic-adrenal-medullary (PAM) axis and hypothalamic-pituitary-adrenal-cortex (HPA) axis
- Sympathetic-adrenal-medullary (SAM) axis and hypothalamic-pituitary-adrenal-cortex (HPA) axis (correct)
How has the environment of laying hens changed over the past 100 years?
How has the environment of laying hens changed over the past 100 years?
What are the key factors to consider when matching an animal to its environment?
What are the key factors to consider when matching an animal to its environment?
Which of the following is NOT a characteristic of a good animal welfare assessment method?
Which of the following is NOT a characteristic of a good animal welfare assessment method?
What is the importance of considering the physiology of the stress response in animal management?
What is the importance of considering the physiology of the stress response in animal management?
What is the main point emphasized in this content regarding animal welfare and management?
What is the main point emphasized in this content regarding animal welfare and management?
What is the role of MHC molecules in the acquired immune response?
What is the role of MHC molecules in the acquired immune response?
What is the primary function of the neuroendocrine-immune system?
What is the primary function of the neuroendocrine-immune system?
What are the primary effects of pro-inflammatory cytokines on the body?
What are the primary effects of pro-inflammatory cytokines on the body?
What is the primary function of hepatic acute-phase proteins (APP)?
What is the primary function of hepatic acute-phase proteins (APP)?
Which of the following is NOT a characteristic of the acquired immune response?
Which of the following is NOT a characteristic of the acquired immune response?
What is Systemic Inflammatory Response Syndrome (SIRS)?
What is Systemic Inflammatory Response Syndrome (SIRS)?
Which of the following is a key characteristic of the innate immune response?
Which of the following is a key characteristic of the innate immune response?
What type of immunity is responsible for providing long-term protection against pathogens?
What type of immunity is responsible for providing long-term protection against pathogens?
Which of the following is NOT a step involved in the process of antigen recognition by the acquired immune response?
Which of the following is NOT a step involved in the process of antigen recognition by the acquired immune response?
What is the primary effect of DNA methylation on gene activity?
What is the primary effect of DNA methylation on gene activity?
Which of the following is NOT a known mechanism of epigenetic modification?
Which of the following is NOT a known mechanism of epigenetic modification?
How do histone modifications influence gene activity?
How do histone modifications influence gene activity?
What is the relationship between the GR gene and stress response?
What is the relationship between the GR gene and stress response?
How can epigenetics be targeted to improve livestock stress resilience?
How can epigenetics be targeted to improve livestock stress resilience?
What is the role of miRNA-18 and miRNA-124a in regulating GR levels?
What is the role of miRNA-18 and miRNA-124a in regulating GR levels?
What is the significance of the zebra finch embryo's response to maternal song at higher temperatures?
What is the significance of the zebra finch embryo's response to maternal song at higher temperatures?
Which of the following is a potential consequence of chronic stress?
Which of the following is a potential consequence of chronic stress?
What is the estimated heritability of the cortisol response 60 minutes after an ACTH challenge in porcine?
What is the estimated heritability of the cortisol response 60 minutes after an ACTH challenge in porcine?
What is the estimated heritability of cortisol levels at awakening in humans?
What is the estimated heritability of cortisol levels at awakening in humans?
Which of the following is NOT a modification that can occur on histone tails?
Which of the following is NOT a modification that can occur on histone tails?
What is the role of microRNAs in regulating gene expression?
What is the role of microRNAs in regulating gene expression?
Which of the following is an example of a pathogen-associated molecular pattern (PAMP)?
Which of the following is an example of a pathogen-associated molecular pattern (PAMP)?
How do modifications to histone tails affect gene expression?
How do modifications to histone tails affect gene expression?
What does the acronym 'H2' stand for in the context of this content?
What does the acronym 'H2' stand for in the context of this content?
Which of the following is a stress hormone that can be used to measure individual resilience to stressors?
Which of the following is a stress hormone that can be used to measure individual resilience to stressors?
If you were looking for a fish species that will grow well in warm greenhouse water, which species might be most appropriate?
If you were looking for a fish species that will grow well in warm greenhouse water, which species might be most appropriate?
Which breed of cattle would be most appropriate for increasing milk production in Brazil?
Which breed of cattle would be most appropriate for increasing milk production in Brazil?
If you were faced with the challenge of increasing resistance of sheep to gastrointestinal parasites, which genetics could be introgressed into Canadian flocks?
If you were faced with the challenge of increasing resistance of sheep to gastrointestinal parasites, which genetics could be introgressed into Canadian flocks?
Which of the following factors could contribute to an increased risk of viral infection?
Which of the following factors could contribute to an increased risk of viral infection?
What is the significance of the statement that "viral infection worsens when circadian rhythm is abolished by disruption of a key circadian clock gene encoding the transcription factor BMAL1"?
What is the significance of the statement that "viral infection worsens when circadian rhythm is abolished by disruption of a key circadian clock gene encoding the transcription factor BMAL1"?
Based on the information provided, what is the relationship between GHG emissions and the production of Q0 in Northern Europe?
Based on the information provided, what is the relationship between GHG emissions and the production of Q0 in Northern Europe?
How could genetic introgression be used to improve sheep resistance to gastrointestinal parasites?
How could genetic introgression be used to improve sheep resistance to gastrointestinal parasites?
What is the main implication of seasonal variation in human BMAL1 levels?
What is the main implication of seasonal variation in human BMAL1 levels?
Flashcards
Neuroendocrine-immune system
Neuroendocrine-immune system
Integral system that communicates to regulate immune response effectively.
Pro-inflammatory cytokines
Pro-inflammatory cytokines
Signaling molecules like TNFα, IL-1, and IL-6 that activate the immune response.
Acute-phase response
Acute-phase response
Systemic reaction to infection that helps fight pathogens but may cause side effects.
Systemic Inflammatory Response Syndrome (SIRS)
Systemic Inflammatory Response Syndrome (SIRS)
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Sepsis
Sepsis
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Hepatic acute-phase proteins (APP)
Hepatic acute-phase proteins (APP)
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Acquired immunity
Acquired immunity
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Immunological memory
Immunological memory
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RCP6 and RCP8.5
RCP6 and RCP8.5
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Dairy Production in Brazil
Dairy Production in Brazil
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Circadian Rhythms and Viral Infections
Circadian Rhythms and Viral Infections
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Genetic Resistance in Sheep
Genetic Resistance in Sheep
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Alternative Breeds for Sheep Resistance
Alternative Breeds for Sheep Resistance
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Fish Species in Aquaponics
Fish Species in Aquaponics
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Impact of BMAL1 on Infections
Impact of BMAL1 on Infections
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Matching Livestock to Environment
Matching Livestock to Environment
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Mycotoxins
Mycotoxins
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Corticosterone response
Corticosterone response
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Histone proteins
Histone proteins
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Chromatin modifications
Chromatin modifications
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Noncoding RNAs (ncRNA)
Noncoding RNAs (ncRNA)
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MicroRNA (miRNA)
MicroRNA (miRNA)
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Bacterial endotoxin
Bacterial endotoxin
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Epigenetics of stress
Epigenetics of stress
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Heritability estimates
Heritability estimates
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DNA methylation
DNA methylation
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Histone modification
Histone modification
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Neuroendocrine-immune genes
Neuroendocrine-immune genes
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GR gene and epigenetics
GR gene and epigenetics
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miRNA role
miRNA role
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HPA axis
HPA axis
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Polymorphisms in USP8
Polymorphisms in USP8
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Genetic and Epigenetic Matching
Genetic and Epigenetic Matching
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Impact of Housing Systems
Impact of Housing Systems
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Stress-Related Health Issues
Stress-Related Health Issues
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Matching Exotic Species
Matching Exotic Species
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Endangered Species Reintroduction
Endangered Species Reintroduction
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Neuroendocrine Stress Response
Neuroendocrine Stress Response
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SAM and HPA Axes
SAM and HPA Axes
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Stress Management Practices
Stress Management Practices
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B cell receptors (BCR)
B cell receptors (BCR)
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Plasma cells
Plasma cells
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T cell receptors (TCR)
T cell receptors (TCR)
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Major histocompatibility complex (MHC)
Major histocompatibility complex (MHC)
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Humoral immunity
Humoral immunity
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Cell-mediated immunity (CMIR)
Cell-mediated immunity (CMIR)
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Acquired immune response
Acquired immune response
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Memory B and T cells
Memory B and T cells
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Study Notes
Animal Health and Stress
- Animal health is crucial for livestock and aquaculture producers, impacting production, product quality, and disease risk.
- Consumers demand high-quality, ethically produced animal products at reasonable prices.
- Many livestock pathogens are zoonotic, meaning they can be transmitted to humans, making animal health crucial for human health.
Antimicrobial Resistance (AMR)
- Antibiotics and other antimicrobials have been heavily used in livestock and aquaculture, contributing to AMR.
- AMR pathogens are a significant concern and new strategies to maintain animal health are needed.
Animal Stress Response
- Domesticated animals experience various stressors (psychological, physical, chemical, biological).
- Stress is defined as something that disrupts homeostasis and elicits a response.
- The stress response is a conserved evolutionary response to perceived danger. It activates various physiological systems, including cardiovascular, metabolic, musculoskeletal, neuroendocrine, and immune systems. The response can manifest as "fight", "flight" or "freeze".
- Excessive or chronic stress can lead to psychological, metabolic, reproductive, and immunological disorders, as well as increased susceptibility to infections and autoimmune diseases, and cancer.
Animal Resilience to Stress
- Resilient animals can withstand, adapt to, and recover from stress, maintaining homeostasis.
- Genetics, environment, and epigenetic mechanisms influence stress resilience.
- Animals with lower stress resilience may be more susceptible to disease from exposure to stressors.
Examples of Stressors
- Physical stressors: heat, cold, transport, noise, electrical restraint
- Chemical stressors: mycotoxins, bacterial toxins, pro-inflammatory cytokines, neuropeptides
- Biological stressors: microbes, pathogens, parasites, viral infections
- Psychological stressors: isolation, re-grouping, noises
Biomarkers of Stress
- Biomarkers are biological indicators of stress, useful for monitoring animal health.
- Examples include catecholamines, glucocorticoids, ACTH, cytokine levels, various antibodies, and temperature.
Immune System in Response to Stress
- The innate and adaptive immune systems play a vital role in restoring homeostasis.
- Effective immune function is crucial for protecting against pathogens.
- Microbial stressors may affect immune response.
Stress, Disease, and Epigenetics
- Genetic and epigenetic variations contribute to the variability in animal response to stress, and their resilience to disease.
- Stress factors can be influenced by the environment and the animal's genetic predisposition.
- Maternal factors and early life experiences can have long-term effects on immune and physiological development.
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