Podcast
Questions and Answers
Which term is also used to describe C1 inhibitor deficiency?
Which term is also used to describe C1 inhibitor deficiency?
- Recurrent attacks
- Hereditary angioedema (correct)
- Fatal airway swelling
- Cutaneous and submucosal swelling
What is the prevalence of C1 inhibitor deficiency?
What is the prevalence of C1 inhibitor deficiency?
- 1:100,000 (correct)
- 1:50,000
- 1:25,000
- 1:200,000
Who first described C1 inhibitor deficiency?
Who first described C1 inhibitor deficiency?
- Michael D Tarzi
- William Osler (correct)
- 24 year old woman
- Immunology Lecturer
What are the key clinical features of C1 inhibitor deficiency?
What are the key clinical features of C1 inhibitor deficiency?
What is the acute treatment of choice for C1 inhibitor deficiency?
What is the acute treatment of choice for C1 inhibitor deficiency?
What is the potential consequence of C1 inhibitor deficiency?
What is the potential consequence of C1 inhibitor deficiency?
What is the role of C1 inhibitor concentrate in the treatment of C1 inhibitor deficiency?
What is the role of C1 inhibitor concentrate in the treatment of C1 inhibitor deficiency?
What is the pathophysiology of C1 inhibitor deficiency?
What is the pathophysiology of C1 inhibitor deficiency?
Who should be tested for C1 inhibitor deficiency?
Who should be tested for C1 inhibitor deficiency?
How can C1 inhibitor deficiency be diagnosed?
How can C1 inhibitor deficiency be diagnosed?
Which of the following is NOT a common feature of angioedema?
Which of the following is NOT a common feature of angioedema?
What is one of the causes of spontaneous angioedema?
What is one of the causes of spontaneous angioedema?
What is the inheritance pattern of C1 inhibitor deficiency?
What is the inheritance pattern of C1 inhibitor deficiency?
What is the major negative regulator of the classical complement pathway?
What is the major negative regulator of the classical complement pathway?
Which component of the complement system binds to antibody constant regions?
Which component of the complement system binds to antibody constant regions?
What is the role of C1 inhibitor in the classical complement pathway?
What is the role of C1 inhibitor in the classical complement pathway?
Which type of HAE is characterized by deletions or missense mutations in the C1 inhibitor gene?
Which type of HAE is characterized by deletions or missense mutations in the C1 inhibitor gene?
What should be checked if serum C4 levels are found to be very low?
What should be checked if serum C4 levels are found to be very low?
What is the typical cost per treated attack of angioedema?
What is the typical cost per treated attack of angioedema?
How does having a genetic condition like C1 inhibitor deficiency affect one's relationship with potential partners?
How does having a genetic condition like C1 inhibitor deficiency affect one's relationship with potential partners?
Which cells are enriched in the synovium of patients with rheumatoid arthritis?
Which cells are enriched in the synovium of patients with rheumatoid arthritis?
Which cells are key effectors in rheumatoid arthritis, responsible for phagocytosis and cytokine production?
Which cells are key effectors in rheumatoid arthritis, responsible for phagocytosis and cytokine production?
What is the suggested initiating cause of rheumatoid arthritis?
What is the suggested initiating cause of rheumatoid arthritis?
What is the composition of synovial tissue in rheumatoid arthritis?
What is the composition of synovial tissue in rheumatoid arthritis?
What is the role of cytokines in rheumatoid arthritis?
What is the role of cytokines in rheumatoid arthritis?
What is the characteristic feature of joint destruction in rheumatoid arthritis?
What is the characteristic feature of joint destruction in rheumatoid arthritis?
What is the suggested role of Th17 cells in rheumatoid arthritis?
What is the suggested role of Th17 cells in rheumatoid arthritis?
What cells are responsible for the production of auto-antibodies associated with rheumatoid arthritis?
What cells are responsible for the production of auto-antibodies associated with rheumatoid arthritis?
What is the suggested genetic risk factor for rheumatoid arthritis?
What is the suggested genetic risk factor for rheumatoid arthritis?
What is the characteristic feature of synovial tissue in rheumatoid arthritis?
What is the characteristic feature of synovial tissue in rheumatoid arthritis?
Which of the following is a clinical marker of rheumatoid arthritis (RA)?
Which of the following is a clinical marker of rheumatoid arthritis (RA)?
What is the specificity of anti-cyclic citrullinated peptide (CCP) antibodies in diagnosing RA?
What is the specificity of anti-cyclic citrullinated peptide (CCP) antibodies in diagnosing RA?
What is the role of anti-CCP antibodies in the pathogenesis of RA?
What is the role of anti-CCP antibodies in the pathogenesis of RA?
Which process is responsible for the detection of citrullinated self proteins in RA patients by anti-CCP antibodies?
Which process is responsible for the detection of citrullinated self proteins in RA patients by anti-CCP antibodies?
Which of the following regions in the body is NOT commonly affected by RA?
Which of the following regions in the body is NOT commonly affected by RA?
What percentage of patients with RA have rheumatoid factor (RF)?
What percentage of patients with RA have rheumatoid factor (RF)?
What is the incidence of RA in North America?
What is the incidence of RA in North America?
What is the concordance rate of RA in monozygotic twins?
What is the concordance rate of RA in monozygotic twins?
Which gene accounts for 30-50% of the overall genetic risk of RA?
Which gene accounts for 30-50% of the overall genetic risk of RA?
What is one of the environmental factors associated with an increased risk of RA?
What is one of the environmental factors associated with an increased risk of RA?
Which of the following best describes rheumatoid arthritis (RA)?
Which of the following best describes rheumatoid arthritis (RA)?
What is the prevalence of rheumatoid arthritis worldwide?
What is the prevalence of rheumatoid arthritis worldwide?
Which of the following antibodies is often present in individuals with rheumatoid arthritis?
Which of the following antibodies is often present in individuals with rheumatoid arthritis?
What are the characteristic symptoms of rheumatoid arthritis?
What are the characteristic symptoms of rheumatoid arthritis?
What is the impact of rheumatoid arthritis on mortality and life expectancy?
What is the impact of rheumatoid arthritis on mortality and life expectancy?
What is the goal of treatment for rheumatoid arthritis?
What is the goal of treatment for rheumatoid arthritis?
What is the role of cytokines in rheumatoid arthritis?
What is the role of cytokines in rheumatoid arthritis?
What is the difference between healthy inflammation and pathological inflammation?
What is the difference between healthy inflammation and pathological inflammation?
What is the impact of chronic inflammation on tissue?
What is the impact of chronic inflammation on tissue?
What is the term used to describe immune responses to self-antigens in rheumatoid arthritis?
What is the term used to describe immune responses to self-antigens in rheumatoid arthritis?
