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Questions and Answers
What is the specificity of anti-cyclic citrullinated peptide (anti-CCP) antibodies in detecting RA?
What is the specificity of anti-cyclic citrullinated peptide (anti-CCP) antibodies in detecting RA?
- 80%
- 50%
- 70%
- 98% (correct)
In patients with RA, what is the main target of antibodies directed against CCP?
In patients with RA, what is the main target of antibodies directed against CCP?
- White blood cells
- Citrullinated self proteins (correct)
- Erythrocytes
- Platelets
Which of the following is true about rheumatoid factor (RF) in the context of RA?
Which of the following is true about rheumatoid factor (RF) in the context of RA?
- Not present in seronegative RA patients
- Found in some healthy individuals (correct)
- Levels correlate with disease activity
- Specific for RA only
What is the role of citrullination in rheumatoid arthritis pathogenesis?
What is the role of citrullination in rheumatoid arthritis pathogenesis?
Which of the following statements is true regarding the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in healthy individuals?
Which of the following statements is true regarding the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in healthy individuals?
How do anti-CCP+ RA patients generally compare in terms of disease course when compared to RF+ RA patients?
How do anti-CCP+ RA patients generally compare in terms of disease course when compared to RF+ RA patients?
Which cell type is enriched in the RA joint but has a defect in their suppressive function?
Which cell type is enriched in the RA joint but has a defect in their suppressive function?
Which treatment effectively depletes follicular B cells in RA?
Which treatment effectively depletes follicular B cells in RA?
Which immune cells are key effectors in RA, responsible for phagocytosis, antigen presentation, and cytokine production?
Which immune cells are key effectors in RA, responsible for phagocytosis, antigen presentation, and cytokine production?
What contributes to the complex cellular interactions in rheumatoid arthritis according to Smolen et al.?
What contributes to the complex cellular interactions in rheumatoid arthritis according to Smolen et al.?
Which antibody type is usually present before the onset of symptoms in RA?
Which antibody type is usually present before the onset of symptoms in RA?
What is reversed by blocking TNF according to the text provided?
What is reversed by blocking TNF according to the text provided?
Which factor has been suggested as one of the initiating causes of Rheumatoid Arthritis (RA)?
Which factor has been suggested as one of the initiating causes of Rheumatoid Arthritis (RA)?
What is the main effect of anti-CCP antibodies in Rheumatoid Arthritis (RA)?
What is the main effect of anti-CCP antibodies in Rheumatoid Arthritis (RA)?
Which cells undergo a special form of cell death called 'NETosis' in the context of Rheumatoid Arthritis (RA)?
Which cells undergo a special form of cell death called 'NETosis' in the context of Rheumatoid Arthritis (RA)?
What is the primary composition of synovial tissue in Rheumatoid Arthritis (RA)?
What is the primary composition of synovial tissue in Rheumatoid Arthritis (RA)?
Which molecular mechanism leads to joint space narrowing in Rheumatoid Arthritis (RA)?
Which molecular mechanism leads to joint space narrowing in Rheumatoid Arthritis (RA)?
What effect does citrullinated protein release through NETosis have on Rheumatoid Arthritis (RA)?
What effect does citrullinated protein release through NETosis have on Rheumatoid Arthritis (RA)?
Which mechanism is proposed to explain the role of anti-CCP immune complexes in enhancing inflammation in mice with mild synovitis?
Which mechanism is proposed to explain the role of anti-CCP immune complexes in enhancing inflammation in mice with mild synovitis?
What is a potential effect of anti-CCP immune complexes in inducing inflammation in the context of rheumatoid arthritis?
What is a potential effect of anti-CCP immune complexes in inducing inflammation in the context of rheumatoid arthritis?
How do anti-CCP immune complexes contribute to the development and severity of inflammation in mice with mild synovitis?
How do anti-CCP immune complexes contribute to the development and severity of inflammation in mice with mild synovitis?
What is a potential consequence of anti-CCP immune complexes interacting with inflammatory cells?
What is a potential consequence of anti-CCP immune complexes interacting with inflammatory cells?
How do anti-CCP immune complexes contribute to the severity of inflammation in mice with mild synovitis?
How do anti-CCP immune complexes contribute to the severity of inflammation in mice with mild synovitis?
Which process is implicated in the ability of anti-CCP immune complexes to exacerbate inflammation in cases where mild synovitis is present?
Which process is implicated in the ability of anti-CCP immune complexes to exacerbate inflammation in cases where mild synovitis is present?
What is the primary characteristic of rheumatoid arthritis (RA) compared to healthy inflammation?
What is the primary characteristic of rheumatoid arthritis (RA) compared to healthy inflammation?
Which autoantibodies are often present in individuals with RA?
Which autoantibodies are often present in individuals with RA?
What is the significance of Cyclic citrullinated peptide (anti-CCP) antibodies in RA?
What is the significance of Cyclic citrullinated peptide (anti-CCP) antibodies in RA?
How do women differ from men in terms of risk related to autoimmunity in RA?
How do women differ from men in terms of risk related to autoimmunity in RA?
What does citrullination refer to in the context of RA?
What does citrullination refer to in the context of RA?
How does the presence of anti-CCP antibodies impact the diagnosis and management of RA?
How does the presence of anti-CCP antibodies impact the diagnosis and management of RA?
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