203: Symposium: Systemic Inflammatory Disease
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Questions and Answers

What is the specificity of anti-cyclic citrullinated peptide (anti-CCP) antibodies in detecting RA?

  • 80%
  • 50%
  • 70%
  • 98% (correct)

    • In patients with RA, what is the main target of antibodies directed against CCP?

  • White blood cells
  • Citrullinated self proteins (correct)
  • Erythrocytes
  • Platelets

    • Which of the following is true about rheumatoid factor (RF) in the context of RA?

  • Not present in seronegative RA patients
  • Found in some healthy individuals (correct)
  • Levels correlate with disease activity
  • Specific for RA only

    • What is the role of citrullination in rheumatoid arthritis pathogenesis?

    <p>Induces antibody response against self proteins</p> Signup and view all the answers

    Which of the following statements is true regarding the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in healthy individuals?

    <p>Rarely found in those who go on to develop RA</p> Signup and view all the answers

    How do anti-CCP+ RA patients generally compare in terms of disease course when compared to RF+ RA patients?

    <p>More aggressive clinical course</p> Signup and view all the answers

    Which cell type is enriched in the RA joint but has a defect in their suppressive function?

    <p>T regulatory cells</p> Signup and view all the answers

    Which treatment effectively depletes follicular B cells in RA?

    <p>Monoclonal anti-CD20 antibodies</p> Signup and view all the answers

    Which immune cells are key effectors in RA, responsible for phagocytosis, antigen presentation, and cytokine production?

    <p>Macrophages</p> Signup and view all the answers

    What contributes to the complex cellular interactions in rheumatoid arthritis according to Smolen et al.?

    <p>Genetic and non-genetic risk factors</p> Signup and view all the answers

    Which antibody type is usually present before the onset of symptoms in RA?

    <p>Cyclic citrullinated peptide (anti-CCP) antibodies</p> Signup and view all the answers

    What is reversed by blocking TNF according to the text provided?

    <p>Defect in T regulatory cell suppressive function</p> Signup and view all the answers

    Which factor has been suggested as one of the initiating causes of Rheumatoid Arthritis (RA)?

    <p>Citrullination process triggered by bacterial infections</p> Signup and view all the answers

    What is the main effect of anti-CCP antibodies in Rheumatoid Arthritis (RA)?

    <p>Promotion of osteoclast differentiation and activation</p> Signup and view all the answers

    Which cells undergo a special form of cell death called 'NETosis' in the context of Rheumatoid Arthritis (RA)?

    <p>Neutrophils</p> Signup and view all the answers

    What is the primary composition of synovial tissue in Rheumatoid Arthritis (RA)?

    <p>Macrophages (40%), Fibroblast and endothelial cells (10-15%), T lymphocytes (40%)</p> Signup and view all the answers

    Which molecular mechanism leads to joint space narrowing in Rheumatoid Arthritis (RA)?

    <p>Enhanced NETosis with release of citrullinated proteins</p> Signup and view all the answers

    What effect does citrullinated protein release through NETosis have on Rheumatoid Arthritis (RA)?

    <p>'NETosis' leads to biomechanical dysfunction and bone erosion</p> Signup and view all the answers

    Which mechanism is proposed to explain the role of anti-CCP immune complexes in enhancing inflammation in mice with mild synovitis?

    <p>Activation of inflammatory cells</p> Signup and view all the answers

    What is a potential effect of anti-CCP immune complexes in inducing inflammation in the context of rheumatoid arthritis?

    <p>Production of NETs by neutrophils</p> Signup and view all the answers

    How do anti-CCP immune complexes contribute to the development and severity of inflammation in mice with mild synovitis?

    <p>By activating inflammatory cells</p> Signup and view all the answers

    What is a potential consequence of anti-CCP immune complexes interacting with inflammatory cells?

    <p>Activation of osteoclast differentiation</p> Signup and view all the answers

    How do anti-CCP immune complexes contribute to the severity of inflammation in mice with mild synovitis?

    <p>By enhancing NET production from neutrophils</p> Signup and view all the answers

    Which process is implicated in the ability of anti-CCP immune complexes to exacerbate inflammation in cases where mild synovitis is present?

    <p>Inducing citrullination of proteins</p> Signup and view all the answers

    What is the primary characteristic of rheumatoid arthritis (RA) compared to healthy inflammation?

    <p>Occurrence of joint destruction</p> Signup and view all the answers

    Which autoantibodies are often present in individuals with RA?

    <p>Rheumatoid factor (RF)</p> Signup and view all the answers

    What is the significance of Cyclic citrullinated peptide (anti-CCP) antibodies in RA?

    <p>They accelerate joint destruction</p> Signup and view all the answers

    How do women differ from men in terms of risk related to autoimmunity in RA?

    <p>Women are at a higher risk of developing autoimmunity</p> Signup and view all the answers

    What does citrullination refer to in the context of RA?

    <p>A process involving the conversion of arginine to citrulline</p> Signup and view all the answers

    How does the presence of anti-CCP antibodies impact the diagnosis and management of RA?

    <p>It increases the accuracy of diagnosis when combined with other clinical tests</p> Signup and view all the answers

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