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Anesthesia Infusion: Front-End Kinetics and Posology

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Anesthesia Infusion: Front-End Kinetics and Posology

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Questions and Answers

What is the primary focus of the simulations in the context of opioids?

Infusion back-end pharmacokinetic behavior

Infusion front-end pharmacokinetic behavior (correct)

Steady-state concentration analysis

Bolus injection kinetics

Which of the following opioids takes the longest to reach 50% decrement in Ce, based on the infusion front-end kinetics?

Morphine (correct)

Hydromorphone

Alfentanil

Fetanyl

What is the unit of measurement for the time to reach 50% decrement in Ce, according to the infusion front-end kinetics data?

Minutes (correct)

Hours

Seconds

Days

Which of the following statements is true about the infusion back-end kinetics graph?

The y-axis represents the time in minutes Signup and view all the answers

What is the common factor among the opioids listed in the infusion front-end kinetics data, in terms of their pharmacological application?

They are all used to treat pain Signup and view all the answers

Why does peak drug effect not occur immediately after a bolus injection?

Because the drug must be delivered to the site of action before it can elicit the desired therapeutic effect Signup and view all the answers

What is the role of the central compartment concentration in the biophase model?

It drives the concentration in the effect site Signup and view all the answers

What is the key pharmacobiophasics parameter that characterizes the rate of equilibration between plasma and effect site concentrations?

ke0 Signup and view all the answers

What is the primary advantage of PD synergistic combinations in anesthesiology?

They enable the therapeutic goals of anesthesia to be achieved with less toxicity and faster recovery Signup and view all the answers

What is the characteristic of drugs that reach peak effect site concentration more rapidly?

They are small and lipid-soluble Signup and view all the answers

What is the definition of minimum alveolar concentration (MAC) of an anesthetic vapor?

The steady-state concentration at which 50% of patients do not move in response to a surgical incision Signup and view all the answers

Under what conditions are MAC values typically measured?

At normal body temperature and 1 atm Signup and view all the answers

What is the purpose of the defined stimulus in MAC measurements?

To provoke a movement response in the patient Signup and view all the answers

What is the significance of the 50% threshold in MAC measurements?

It represents the midpoint of the anesthetic's effect Signup and view all the answers

What type of subjects are typically used to measure MAC values?

Healthy, nonpregnant adults Signup and view all the answers