Anesthesia Infusion: Front-End Kinetics and Posology

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Questions and Answers

What is the primary focus of the simulations in the context of opioids?

  • Infusion back-end pharmacokinetic behavior
  • Infusion front-end pharmacokinetic behavior (correct)
  • Steady-state concentration analysis
  • Bolus injection kinetics

Which of the following opioids takes the longest to reach 50% decrement in Ce, based on the infusion front-end kinetics?

  • Morphine (correct)
  • Hydromorphone
  • Alfentanil
  • Fetanyl

What is the unit of measurement for the time to reach 50% decrement in Ce, according to the infusion front-end kinetics data?

  • Minutes (correct)
  • Hours
  • Seconds
  • Days

Which of the following statements is true about the infusion back-end kinetics graph?

<p>The y-axis represents the time in minutes (B)</p> Signup and view all the answers

What is the common factor among the opioids listed in the infusion front-end kinetics data, in terms of their pharmacological application?

<p>They are all used to treat pain (B)</p> Signup and view all the answers

Why does peak drug effect not occur immediately after a bolus injection?

<p>Because the drug must be delivered to the site of action before it can elicit the desired therapeutic effect (A)</p> Signup and view all the answers

What is the role of the central compartment concentration in the biophase model?

<p>It drives the concentration in the effect site (D)</p> Signup and view all the answers

What is the key pharmacobiophasics parameter that characterizes the rate of equilibration between plasma and effect site concentrations?

<p>ke0 (D)</p> Signup and view all the answers

What is the primary advantage of PD synergistic combinations in anesthesiology?

<p>They enable the therapeutic goals of anesthesia to be achieved with less toxicity and faster recovery (C)</p> Signup and view all the answers

What is the characteristic of drugs that reach peak effect site concentration more rapidly?

<p>They are small and lipid-soluble (D)</p> Signup and view all the answers

What is the definition of minimum alveolar concentration (MAC) of an anesthetic vapor?

<p>The steady-state concentration at which 50% of patients do not move in response to a surgical incision (B)</p> Signup and view all the answers

Under what conditions are MAC values typically measured?

<p>At normal body temperature and 1 atm (B)</p> Signup and view all the answers

What is the purpose of the defined stimulus in MAC measurements?

<p>To provoke a movement response in the patient (C)</p> Signup and view all the answers

What is the significance of the 50% threshold in MAC measurements?

<p>It represents the midpoint of the anesthetic's effect (B)</p> Signup and view all the answers

What type of subjects are typically used to measure MAC values?

<p>Healthy, nonpregnant adults (A)</p> Signup and view all the answers

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