Podcast
Questions and Answers
What factor can make acidic tissues difficult to anesthetize with local anesthetic?
What factor can make acidic tissues difficult to anesthetize with local anesthetic?
- Ester hydrolysis
- Increased lipid solubility
- Alkaline pH (correct)
- Vasoconstriction
How does small doses of epinephrine added to local anesthetic affect duration of anesthesia?
How does small doses of epinephrine added to local anesthetic affect duration of anesthesia?
- Increases blood flow to the site
- Decreases lipid solubility
- Prolongs duration through vasoconstriction (correct)
- Enhances ester hydrolysis
Which type of metabolism do ester local anesthetics predominantly undergo?
Which type of metabolism do ester local anesthetics predominantly undergo?
- Ester hydrolysis (correct)
- Reduction
- Oxidation
- Glycosylation
How does cocaine affect vasoconstriction?
How does cocaine affect vasoconstriction?
How does increased lipid solubility influence the onset time of local anesthetics?
How does increased lipid solubility influence the onset time of local anesthetics?
What characteristic of local anesthetics is influenced by lipid solubility?
What characteristic of local anesthetics is influenced by lipid solubility?
Which of the following is the most important factor affecting the speed of onset of an inhaled anesthetic?
Which of the following is the most important factor affecting the speed of onset of an inhaled anesthetic?
How does the solubility of an inhaled anesthetic affect its pharmacokinetics?
How does the solubility of an inhaled anesthetic affect its pharmacokinetics?
How does the solubility of an inhaled anesthetic affect its elimination from the body?
How does the solubility of an inhaled anesthetic affect its elimination from the body?
How can vessel-poor tissues affect the pharmacokinetics of an anesthetic during a long procedure?
How can vessel-poor tissues affect the pharmacokinetics of an anesthetic during a long procedure?
Which of the following is the most important factor affecting the distribution of an intravenous anesthetic in the body?
Which of the following is the most important factor affecting the distribution of an intravenous anesthetic in the body?
How does the rate of hepatic metabolism affect the pharmacokinetics of an intravenous anesthetic?
How does the rate of hepatic metabolism affect the pharmacokinetics of an intravenous anesthetic?
Which enzyme is responsible for the metabolism of amide-type local anesthetics?
Which enzyme is responsible for the metabolism of amide-type local anesthetics?
What is the main pathway of metabolism for amide-type local anesthetics?
What is the main pathway of metabolism for amide-type local anesthetics?
Which local anesthetic is associated with methemoglobinemia and is typically used only topically?
Which local anesthetic is associated with methemoglobinemia and is typically used only topically?
Why is chloroprocaine not used in spinal anesthesia?
Why is chloroprocaine not used in spinal anesthesia?
Which local anesthetic has a butyl group attached to its aromatic group, allowing it to stay in the tissue surrounding a nerve for an extended period of time?
Which local anesthetic has a butyl group attached to its aromatic group, allowing it to stay in the tissue surrounding a nerve for an extended period of time?
What is the main reason for the low potency, slow onset, and short duration of action observed in ester-type local anesthetics?
What is the main reason for the low potency, slow onset, and short duration of action observed in ester-type local anesthetics?
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