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Questions and Answers
Which of the following is a characteristic of hemolytic anemia caused by disseminated intravascular coagulation (DIC)?
Which of the following is a characteristic of hemolytic anemia caused by disseminated intravascular coagulation (DIC)?
What is a common clinical feature of Heinz body anemia?
What is a common clinical feature of Heinz body anemia?
Which of the following is a cause of Microangiopathic Hemolytic Anemia (MAHA)?
Which of the following is a cause of Microangiopathic Hemolytic Anemia (MAHA)?
Which of the following is a type of red blood cell fragment associated with Microangiopathic Hemolytic Anemia (MAHA)?
Which of the following is a type of red blood cell fragment associated with Microangiopathic Hemolytic Anemia (MAHA)?
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Which of the following is a characteristic of hemolytic anemia caused by congenital spherocytosis?
Which of the following is a characteristic of hemolytic anemia caused by congenital spherocytosis?
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Which of the following conditions typically causes a prolonged and severe form of hemolytic anemia?
Which of the following conditions typically causes a prolonged and severe form of hemolytic anemia?
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Which of the following is a clinical manifestation of hemolytic anemia caused by congenital spherocytosis?
Which of the following is a clinical manifestation of hemolytic anemia caused by congenital spherocytosis?
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Which of the following are considered extrinsic causes of hemolytic anemia?
Which of the following are considered extrinsic causes of hemolytic anemia?
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Which of the following is a possible treatment for autoimmune hemolytic anemia (AIHA)?
Which of the following is a possible treatment for autoimmune hemolytic anemia (AIHA)?
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What is a common feature associated with autoimmune hemolytic anemia (AIHA)?
What is a common feature associated with autoimmune hemolytic anemia (AIHA)?
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Which clinical feature is indicative of warm AIHA?
Which clinical feature is indicative of warm AIHA?
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What does a positive direct antiglobulin test (DAT) indicate in hemolytic anemia?
What does a positive direct antiglobulin test (DAT) indicate in hemolytic anemia?
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Megaloblastic anemia is characterized by which laboratory finding?
Megaloblastic anemia is characterized by which laboratory finding?
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In acute myeloid leukemia (AML), which type of cells is predominant?
In acute myeloid leukemia (AML), which type of cells is predominant?
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Which of the following statements about megaloblastic anemia is true?
Which of the following statements about megaloblastic anemia is true?
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What is a characteristic cytological finding in someone with acute lymphoblastic leukemia?
What is a characteristic cytological finding in someone with acute lymphoblastic leukemia?
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Which of the following findings is NOT typical of hemolytic anemia?
Which of the following findings is NOT typical of hemolytic anemia?
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What is the significance of detecting antigastric parietal cell autoantibodies?
What is the significance of detecting antigastric parietal cell autoantibodies?
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Which type of anemia is associated with splenomegaly?
Which type of anemia is associated with splenomegaly?
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What effect does methyl dopa therapy have in relation to hemolytic anemia?
What effect does methyl dopa therapy have in relation to hemolytic anemia?
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What typifies chronic hemolytic anemia?
What typifies chronic hemolytic anemia?
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In megaloblastic anemia, what should be anticipated in a bone marrow biopsy?
In megaloblastic anemia, what should be anticipated in a bone marrow biopsy?
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Which of the following is a hallmark finding in patients with acute myeloid leukemia?
Which of the following is a hallmark finding in patients with acute myeloid leukemia?
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Which feature is NOT associated with hypochromic microcytic anemia?
Which feature is NOT associated with hypochromic microcytic anemia?
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What condition is typically characterized by a deficiency of heme synthesis due to genetic mutation?
What condition is typically characterized by a deficiency of heme synthesis due to genetic mutation?
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Which laboratory finding is expected in intrinsic hemolytic anemia?
Which laboratory finding is expected in intrinsic hemolytic anemia?
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Which anemia is characterized by a chronic inflammatory state leading to normal or increased ferritin levels?
Which anemia is characterized by a chronic inflammatory state leading to normal or increased ferritin levels?
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What symptom is commonly associated with sickle cell anemia?
What symptom is commonly associated with sickle cell anemia?
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What laboratory finding is typically elevated in thalassemia?
What laboratory finding is typically elevated in thalassemia?
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In G6PD deficiency, what type of blood cell findings are often seen?
In G6PD deficiency, what type of blood cell findings are often seen?
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Which of the following is a feature of hereditary spherocytosis?
Which of the following is a feature of hereditary spherocytosis?
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Which type of anemia is least likely to show increased total iron binding capacity (TIBC)?
Which type of anemia is least likely to show increased total iron binding capacity (TIBC)?
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What is a common finding in microcytic anemia due to iron deficiency?
What is a common finding in microcytic anemia due to iron deficiency?
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Which type of anemia is associated with an increase in target cells?
Which type of anemia is associated with an increase in target cells?
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What is a typical characteristic of macrocytic anemia?
What is a typical characteristic of macrocytic anemia?
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Which condition can lead to a reduced viability of erythrocytes, specifically noted in hemolytic anemias?
Which condition can lead to a reduced viability of erythrocytes, specifically noted in hemolytic anemias?
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What is a clinical manifestation commonly seen in iron deficiency anemia?
What is a clinical manifestation commonly seen in iron deficiency anemia?
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Flashcards
Hemolytic Anemia
Hemolytic Anemia
A condition where red blood cells are destroyed faster than they can be made.
Spherocytes
Spherocytes
Abnormally round red blood cells that can lead to hemolytic anemia.
Heinz bodies
Heinz bodies
Aggregates of denatured hemoglobin in red blood cells, indicating damage.
Microangiopathic Hemolytic Anemia (MAHA)
Microangiopathic Hemolytic Anemia (MAHA)
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Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic Thrombocytopenic Purpura (TTP)
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Autoimmune Hemolytic Anemia
Autoimmune Hemolytic Anemia
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Disseminated Intravascular Coagulation (DIC)
Disseminated Intravascular Coagulation (DIC)
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Schistocyte
Schistocyte
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Acute Hemolytic Anemia
Acute Hemolytic Anemia
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Extrinsic Hemolytic Anemia
Extrinsic Hemolytic Anemia
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Warm AIHA
Warm AIHA
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Positive DAT
Positive DAT
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Megaloblastic Anemia
Megaloblastic Anemia
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Macro-ovalocytes
Macro-ovalocytes
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Hypercellularity
Hypercellularity
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Reticulocytes
Reticulocytes
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LDH Increase
LDH Increase
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Indirect Bilirubin Increase
Indirect Bilirubin Increase
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Neutropenia
Neutropenia
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Acute Leukemia
Acute Leukemia
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Nucleated Red Blood Cells
Nucleated Red Blood Cells
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Myeloblast
Myeloblast
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Blast Cells
Blast Cells
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Hypochromic Microcytic Anemia
Hypochromic Microcytic Anemia
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Microcytosis
Microcytosis
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Iron Deficiency
Iron Deficiency
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Teardrop Cells
Teardrop Cells
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Ferritin
Ferritin
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Total Iron Binding Capacity (TIBC)
Total Iron Binding Capacity (TIBC)
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Erythroblast
Erythroblast
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Sideroblastic Anemia
Sideroblastic Anemia
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Thalassemia
Thalassemia
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Normochromic Normocytic Anemia
Normochromic Normocytic Anemia
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Hereditary Spherocytosis
Hereditary Spherocytosis
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Sickle Cell Anemia
Sickle Cell Anemia
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G6PD Deficiency
G6PD Deficiency
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Jaundice
Jaundice
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Study Notes
Hypochromic Microcytic Anemia
- Key features: Mean corpuscular hemoglobin (MCH) below 32 g/dL, Mean corpuscular volume (MCV) below 80 fL.
Iron Deficiency Anemia
- Most common type of hypochromic microcytic anemia.
- Symptoms include fatigue, pallor, brittle nails, and pica (craving non-food items).
- Low serum iron, ferritin, and transferrin saturation.
- Bone marrow iron stores are reduced.
- Laboratory tests will show decreased serum iron, ferritin, and transferrin saturation, and elevated serum transferrin receptor.
Anemia of Chronic Disease
- Reduced serum iron, transferrin, and transferrin with normal or elevated ferritin.
- Reduced iron stores in bone marrow.
- Often associated with chronic infections, inflammatory conditions, and autoimmune diseases.
Sideroblastic Anemia
- Increased serum iron, ferritin (iron storage overload), and transferrin saturation.
- Low transferrin
- Associated with genetic mutations or acquired conditions like alcoholism, B6 deficiency and various other medications.
Thalassemia, Abnormal Hemoglobin
- Abnormal hemoglobin studies (HbF/HbA2).
- Normal or elevated serum iron and ferritin.
- Low transferrin.
- Reduced MCV associated with abnormal haemoglobin
Hemolytic Anemia (Normochromic Normocytic Anemia)
- Intrinsic: Hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria (PNH), G6PD deficiency, pyruvate kinase deficiency, sickle cell anemia, and HbC disease.
- Extrinsic: Microangiopathic hemolytic anemia (MAHA), macroangiopathic hemolytic anemia (Macro-AH), autoimmune hemolytic anemia (AIHA) , and other infectious agents and chemicals.
Non-Hemolytic Anemia (Normochromic Normocytic Anemia)
- Causes include iron deficiency, anemia of chronic disease, chronic kidney disease, and Aplastic anemia
Megaloblastic Anemia
- MCV greater than 100 fL.
- Impaired DNA synthesis resulting from vitamin B12 or folate deficiency
- Symptoms include fatigue, headache, palpitations, dyspnea, neurological symptoms (e.g., paresthesias), and macrocytic red blood cells with oval morphology.
- Laboratory findings include high LDH and indirect bilirubin, low haptoglobin, high or normal reticulocytes, hypersegmented neutrophils.
Blast Cells
- Erythroid maturation: Proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, orthochromatic erythroblast, reticulocyte, erythrocyte
- Granulocytic maturation: myeloblast, promyelocyte, myelocyte, metamyelocyte, band neutrophil, neutrophil
- Lymphoid maturation
Myeloid Leukemia (Acute and Chronic)
- Acute Myeloid Leukemia (AML): Rapid onset; presence of immature myeloid blast cells; can present as different subtypes (M0-M7) based on microscopic features.
- Chronic Myeloid Leukemia (CML): Gradual onset, Mature myeloid cells at differential stages are increased, Philadelphia chromosome translocation (t(9;22)).
Lymphoid Leukemia (Acute and Chronic)
- Acute Lymphocytic Leukemia (ALL): Primarily affects children; characterized by lymphoblast cells; further classified as B-ALL or T-ALL based on specific markers.
- Chronic Lymphocytic Leukemia (CLL): Predominantly affects adults; characterized by mature lymphocytes, with 'smudge cells' (fragile B cells).
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Description
This quiz covers various types of anemia, including hypochromic microcytic anemia, iron deficiency anemia, anemia of chronic disease, and sideroblastic anemia. Each type's key features, symptoms, and laboratory findings are outlined for a comprehensive understanding. Test your knowledge on the causes and indicators of these anemic conditions.