Anemia Types Overview
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Questions and Answers

Which of the following is a characteristic of hemolytic anemia caused by disseminated intravascular coagulation (DIC)?

  • Spherocytes
  • Target cells
  • Heinz bodies
  • Schistocytes (correct)
  • What is a common clinical feature of Heinz body anemia?

  • Thrombocytopenia
  • Neonatal jaundice
  • Hemolytic anemia (correct)
  • Splenomegaly
  • Which of the following is a cause of Microangiopathic Hemolytic Anemia (MAHA)?

  • Congenital spherocytosis
  • Thrombotic thrombocytopenic purpura (TTP) (correct)
  • Autoimmune hemolytic anemia (AIHA)
  • All of the above
  • Which of the following is a type of red blood cell fragment associated with Microangiopathic Hemolytic Anemia (MAHA)?

    <p>Schistocyte (C)</p> Signup and view all the answers

    Which of the following is a characteristic of hemolytic anemia caused by congenital spherocytosis?

    <p>Spherocytes (A)</p> Signup and view all the answers

    Which of the following conditions typically causes a prolonged and severe form of hemolytic anemia?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is a clinical manifestation of hemolytic anemia caused by congenital spherocytosis?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following are considered extrinsic causes of hemolytic anemia?

    <p>Microangiopathic hemolytic anemia (MAHA) (C)</p> Signup and view all the answers

    Which of the following is a possible treatment for autoimmune hemolytic anemia (AIHA)?

    <p>All of the above (D)</p> Signup and view all the answers

    What is a common feature associated with autoimmune hemolytic anemia (AIHA)?

    <p>Presence of spherocytes (A)</p> Signup and view all the answers

    Which clinical feature is indicative of warm AIHA?

    <p>Extravascular hemolysis (A)</p> Signup and view all the answers

    What does a positive direct antiglobulin test (DAT) indicate in hemolytic anemia?

    <p>Presence of antibodies on the surface of red blood cells (B)</p> Signup and view all the answers

    Megaloblastic anemia is characterized by which laboratory finding?

    <p>Increased MCV (&gt;100 fL) (B)</p> Signup and view all the answers

    In acute myeloid leukemia (AML), which type of cells is predominant?

    <p>Immature blast cells (B)</p> Signup and view all the answers

    Which of the following statements about megaloblastic anemia is true?

    <p>It is associated with a lack of intrinsic factor. (C)</p> Signup and view all the answers

    What is a characteristic cytological finding in someone with acute lymphoblastic leukemia?

    <p>Condensed nuclear chromatin in lymphoblasts (A)</p> Signup and view all the answers

    Which of the following findings is NOT typical of hemolytic anemia?

    <p>Low indirect bilirubin (B)</p> Signup and view all the answers

    What is the significance of detecting antigastric parietal cell autoantibodies?

    <p>They suggest megaloblastic anemia due to intrinsic factor deficiency. (A)</p> Signup and view all the answers

    Which type of anemia is associated with splenomegaly?

    <p>Autoimmune hemolytic anemia (A)</p> Signup and view all the answers

    What effect does methyl dopa therapy have in relation to hemolytic anemia?

    <p>Induces autoimmune response leading to hemolysis (B)</p> Signup and view all the answers

    What typifies chronic hemolytic anemia?

    <p>Presence of reticulocytes (A)</p> Signup and view all the answers

    In megaloblastic anemia, what should be anticipated in a bone marrow biopsy?

    <p>Hypercellularity (C)</p> Signup and view all the answers

    Which of the following is a hallmark finding in patients with acute myeloid leukemia?

    <p>Blasts with fine azurophilic granules (B)</p> Signup and view all the answers

    Which feature is NOT associated with hypochromic microcytic anemia?

    <p>Increased ferritin levels (C)</p> Signup and view all the answers

    What condition is typically characterized by a deficiency of heme synthesis due to genetic mutation?

    <p>Sideroblastic anemia (C)</p> Signup and view all the answers

    Which laboratory finding is expected in intrinsic hemolytic anemia?

    <p>Increased reticulocyte count (A)</p> Signup and view all the answers

    Which anemia is characterized by a chronic inflammatory state leading to normal or increased ferritin levels?

    <p>Anemia of chronic disease (A)</p> Signup and view all the answers

    What symptom is commonly associated with sickle cell anemia?

    <p>Swelling of joints (C)</p> Signup and view all the answers

    What laboratory finding is typically elevated in thalassemia?

    <p>Serum ferritin (D)</p> Signup and view all the answers

    In G6PD deficiency, what type of blood cell findings are often seen?

    <p>Fragmented cells (D)</p> Signup and view all the answers

    Which of the following is a feature of hereditary spherocytosis?

    <p>Increased reticulocyte count (D)</p> Signup and view all the answers

    Which type of anemia is least likely to show increased total iron binding capacity (TIBC)?

    <p>Anemia of chronic disease (C)</p> Signup and view all the answers

    What is a common finding in microcytic anemia due to iron deficiency?

    <p>Decreased mean corpuscular volume (MCV) (D)</p> Signup and view all the answers

    Which type of anemia is associated with an increase in target cells?

    <p>Thalassemia (D)</p> Signup and view all the answers

    What is a typical characteristic of macrocytic anemia?

    <p>Increased MCV (B)</p> Signup and view all the answers

    Which condition can lead to a reduced viability of erythrocytes, specifically noted in hemolytic anemias?

    <p>Autoimmune hemolytic anemia (B)</p> Signup and view all the answers

    What is a clinical manifestation commonly seen in iron deficiency anemia?

    <p>Nail deformities (A)</p> Signup and view all the answers

    Flashcards

    Hemolytic Anemia

    A condition where red blood cells are destroyed faster than they can be made.

    Spherocytes

    Abnormally round red blood cells that can lead to hemolytic anemia.

    Heinz bodies

    Aggregates of denatured hemoglobin in red blood cells, indicating damage.

    Microangiopathic Hemolytic Anemia (MAHA)

    A type of hemolytic anemia caused by small blood vessel damage.

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    Thrombotic Thrombocytopenic Purpura (TTP)

    A rare blood disorder causing clots that can lead to MAHA.

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    Autoimmune Hemolytic Anemia

    A condition where the immune system attacks its own red blood cells.

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    Disseminated Intravascular Coagulation (DIC)

    A serious condition that leads to widespread clotting and bleeding.

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    Schistocyte

    Fragmented red blood cells seen in certain types of hemolytic anemia.

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    Acute Hemolytic Anemia

    A rapid type of hemolytic anemia that occurs suddenly.

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    Extrinsic Hemolytic Anemia

    Hemolytic anemia caused by external factors outside the red blood cells.

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    Warm AIHA

    Autoimmune hemolytic anemia that occurs at body temperature.

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    Positive DAT

    Direct Coombs test showing antibodies on RBCs.

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    Megaloblastic Anemia

    Macrocytic anemia due to impaired DNA synthesis.

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    Macro-ovalocytes

    Large oval-shaped red blood cells seen in megaloblastic anemia.

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    Hypercellularity

    Increased number of cells in the bone marrow.

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    Reticulocytes

    Immature red blood cells with ribosomal RNA.

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    LDH Increase

    Lactate dehydrogenase levels rise in hemolysis.

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    Indirect Bilirubin Increase

    Byproduct of hemoglobin breakdown, elevated in hemolysis.

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    Neutropenia

    Low levels of neutrophils in the blood.

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    Acute Leukemia

    Rapid onset cancer from immature blood cells.

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    Nucleated Red Blood Cells

    Immature red blood cells still containing a nucleus.

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    Myeloblast

    Immature white blood cells from myeloid lineage.

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    Blast Cells

    Immature cells indicative of various blood cancers.

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    Hypochromic Microcytic Anemia

    Anemia characterized by low MCV (<80 fL) and low MCHC (<32 g/dL), often due to iron deficiency.

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    Microcytosis

    Condition where red blood cells are smaller than normal, typically seen in iron deficiency anemia.

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    Iron Deficiency

    Common cause of hypochromic microcytic anemia due to lack of iron intake or absorption.

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    Teardrop Cells

    Abnormally shaped red blood cells often seen in anemia of chronic disorders.

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    Ferritin

    A protein that stores iron in the body; low levels indicate iron deficiency.

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    Total Iron Binding Capacity (TIBC)

    Test measuring the blood's capacity to bind iron with transferrin; often increased in iron deficiency.

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    Erythroblast

    A precursor to red blood cells involved in iron metabolism; abnormal levels suggest anemia issues.

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    Sideroblastic Anemia

    Anemia caused by the body's inability to properly incorporate iron into hemoglobin despite adequate iron stores.

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    Thalassemia

    Genetic disorder that results in abnormal hemoglobin production, leading to hemolytic anemia.

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    Normochromic Normocytic Anemia

    Anemia with normal MCV and MCHC; often occurs in chronic diseases.

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    Hereditary Spherocytosis

    Genetic condition causing red blood cells to be spherical and fragile.

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    Sickle Cell Anemia

    A genetic disorder where red blood cells become rigid and sickle-shaped, leading to blockages in blood flow.

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    G6PD Deficiency

    Enzyme deficiency that can lead to hemolytic anemia under oxidative stress.

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    Jaundice

    Yellowing of skin and eyes due to excess bilirubin from RBC breakdown, often seen in hemolytic anemia.

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    Study Notes

    Hypochromic Microcytic Anemia

    • Key features: Mean corpuscular hemoglobin (MCH) below 32 g/dL, Mean corpuscular volume (MCV) below 80 fL.

    Iron Deficiency Anemia

    • Most common type of hypochromic microcytic anemia.
    • Symptoms include fatigue, pallor, brittle nails, and pica (craving non-food items).
    • Low serum iron, ferritin, and transferrin saturation.
    • Bone marrow iron stores are reduced.
    • Laboratory tests will show decreased serum iron, ferritin, and transferrin saturation, and elevated serum transferrin receptor.

    Anemia of Chronic Disease

    • Reduced serum iron, transferrin, and transferrin with normal or elevated ferritin.
    • Reduced iron stores in bone marrow.
    • Often associated with chronic infections, inflammatory conditions, and autoimmune diseases.

    Sideroblastic Anemia

    • Increased serum iron, ferritin (iron storage overload), and transferrin saturation.
    • Low transferrin
    • Associated with genetic mutations or acquired conditions like alcoholism, B6 deficiency and various other medications.

    Thalassemia, Abnormal Hemoglobin

    • Abnormal hemoglobin studies (HbF/HbA2).
    • Normal or elevated serum iron and ferritin.
    • Low transferrin.
    • Reduced MCV associated with abnormal haemoglobin

    Hemolytic Anemia (Normochromic Normocytic Anemia)

    • Intrinsic: Hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria (PNH), G6PD deficiency, pyruvate kinase deficiency, sickle cell anemia, and HbC disease.
    • Extrinsic: Microangiopathic hemolytic anemia (MAHA), macroangiopathic hemolytic anemia (Macro-AH), autoimmune hemolytic anemia (AIHA) , and other infectious agents and chemicals.

    Non-Hemolytic Anemia (Normochromic Normocytic Anemia)

    • Causes include iron deficiency, anemia of chronic disease, chronic kidney disease, and Aplastic anemia

    Megaloblastic Anemia

    • MCV greater than 100 fL.
    • Impaired DNA synthesis resulting from vitamin B12 or folate deficiency
    • Symptoms include fatigue, headache, palpitations, dyspnea, neurological symptoms (e.g., paresthesias), and macrocytic red blood cells with oval morphology.
    • Laboratory findings include high LDH and indirect bilirubin, low haptoglobin, high or normal reticulocytes, hypersegmented neutrophils.

    Blast Cells

    • Erythroid maturation: Proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, orthochromatic erythroblast, reticulocyte, erythrocyte
    • Granulocytic maturation: myeloblast, promyelocyte, myelocyte, metamyelocyte, band neutrophil, neutrophil
    • Lymphoid maturation

    Myeloid Leukemia (Acute and Chronic)

    • Acute Myeloid Leukemia (AML): Rapid onset; presence of immature myeloid blast cells; can present as different subtypes (M0-M7) based on microscopic features.
    • Chronic Myeloid Leukemia (CML): Gradual onset, Mature myeloid cells at differential stages are increased, Philadelphia chromosome translocation (t(9;22)).

    Lymphoid Leukemia (Acute and Chronic)

    • Acute Lymphocytic Leukemia (ALL): Primarily affects children; characterized by lymphoblast cells; further classified as B-ALL or T-ALL based on specific markers.
    • Chronic Lymphocytic Leukemia (CLL): Predominantly affects adults; characterized by mature lymphocytes, with 'smudge cells' (fragile B cells).

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    Anemia & Leukemia PDF

    Description

    This quiz covers various types of anemia, including hypochromic microcytic anemia, iron deficiency anemia, anemia of chronic disease, and sideroblastic anemia. Each type's key features, symptoms, and laboratory findings are outlined for a comprehensive understanding. Test your knowledge on the causes and indicators of these anemic conditions.

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