Anemia Overview and Classifications
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Questions and Answers

Which of the following best describes the reticulocyte count in Aplastic Anemia?

  • Increased reticulocyte count
  • Normal reticulocyte count
  • Fluctuating reticulocyte count
  • Decreased reticulocyte count (correct)

What is a significant feature of Normocytic, Normochromic Anemias?

  • Decreased hematocrit
  • High mean corpuscular volume (MCV)
  • Normal or decreased reticulocyte count (correct)
  • Increased hemoglobin levels

Which condition is NOT categorized under the associated conditions of increased reticulocyte count?

  • Paroxysmal Nocturnal Hemoglobinuria (PNH)
  • Sickle Cell Anemia
  • Acute Blood Loss (correct)
  • Porphyria

Which of the following correctly defines anemia?

<p>A decrease below normal in red blood cells, hemoglobin, or hematocrit (C)</p> Signup and view all the answers

Which of the following conditions is characterized by bone marrow hypocellularity?

<p>Aplastic Anemia (D)</p> Signup and view all the answers

Flashcards

Elevated ESR

An elevated erythrocyte sedimentation rate (ESR) is a sign of inflammation in the body.

Anemia

A condition where there's a deficiency of red blood cells, hemoglobin, or packed red blood cell volume (hematocrit).

Normocytic, Normochromic Anemia

A type of anemia where the red blood cell size (mean corpuscular volume - MCV) and hemoglobin content per cell (mean corpuscular hemoglobin - MCHC) are normal.

Aplastic Anemia

A rare and potentially serious bone marrow failure syndrome characterized by a decrease in all blood cell types (pancytopenia) and low reticulocyte count.

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Reticulocyte count

A measure of newly produced red blood cells.

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Pancytopenia

A condition with a decrease in red blood cells, white blood cells, and platelets.

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Reticulocytopenia

A decrease in the number of reticulocytes (immature red blood cells) in the blood.

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Bone marrow hypocellularity

A decrease in the number of cells in the bone marrow.

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Hemolytic Anemia

A group of disorders in which red blood cells are destroyed faster than they can be produced.

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Study Notes

Anemia Overview

  • Anemia is not a disease, but a manifestation of a disease
  • Defined as a decrease below normal of one or more of the following:
    • Number of red blood cells
    • Hemoglobin
    • Packed red blood cell volume (hematocrit)

Classifications of Anemias

Normocytic, Normochromic Anemias

  • MCV and MCHC are both normal
  • Associated conditions:
    • Normal or decreased reticulocyte count
    • Aplastic anemia (rare, potentially deadly bone marrow failure)
    • Kidney disease
    • Acute blood loss
    • Increased reticulocyte count:
      • Paroxysmal nocturnal hemoglobinuria (PNH)
      • PCH (Donath-Landsteiner hemolytic anemia)
      • Sickle cell disease
      • Porphyria
      • Enzyme deficiencies (G6PD, PK)
      • Other hemolytic anemias

Aplastic Anemia

  • Described as a rare but potentially deadly bone marrow failure syndrome
  • Characteristic features:
    • Pancytopenia (marked decrease in RBCs, WBCs, and platelets)
    • Reticulocytopenia
    • Bone marrow hypocellularity
    • Depletion of hematopoietic stem cells

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Description

Explore the different types and classifications of anemia, including normocytic, normochromic anemias, and aplastic anemia. Understand the underlying conditions and laboratory findings associated with these disorders. This quiz is essential for anyone looking to deepen their knowledge of hematology.

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