Anemia Classification and Causes

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15 Questions

Which factor is NOT considered an intrinsic factor leading to anemia?

Malignancy

What blood index value indicates Normocytic Anemia?

25 – 32 pg

Which infection is NOT listed as an extrinsic factor causing anemia?

Hepatitis

What is the average volume of a single RBC in cubic micron (μ3) that indicates Microcytic Anemia?

Less than 80 μ3

Which drug is NOT mentioned as a potential cause of anemia in the text?

Penicillin

What is the classification of anemia based on the size of RBCs and their hemoglobin content?

Normocytic Normochromic Anemia

What causes Microcytic Hypochromic Anemia?

Iron deficiency

What is the cause of Macrocytic Anemia?

Vitamin B12 or folic acid deficiency

What leads to Normocytic Normochromic Anemia?

Acute blood loss

Which type of anemia is characterized by a normal size and hemoglobin content of RBCs but a decreased number of RBCs?

Normocytic Normochromic Anemia

In the osmotic fragility test, what happens to red blood cells in a hypotonic solution?

They burst

What is the normal shape of red blood cells in 0.9% NaCl solution?

They are normal biconcave disc shaped

At what percentage of NaCl does hemolysis begin in normal red blood cells according to the text?

0.45%

At what percentage of NaCl does hemolysis begin in spherocytosis according to the text?

0.7%

In which condition is osmotic fragility increased according to the text?

Hereditary spherocytosis

Study Notes

Anemia Factors

  • Age is NOT considered an intrinsic factor leading to anemia.

Anemia Classification

  • Anemia is classified based on the size of RBCs and their hemoglobin content.

Types of Anemia

  • Microcytic Anemia: characterized by a lower than normal RBC volume (average volume < 80 μ3).
  • Microcytic Hypochromic Anemia: caused by iron deficiency or thalassemia.
  • Macrocytic Anemia: caused by vitamin B12 or folate deficiency.
  • Normocytic Normochromic Anemia: characterized by a normal size and hemoglobin content of RBCs but a decreased number of RBCs.

Osmotic Fragility Test

  • In a hypotonic solution, red blood cells swell and eventually lyse.
  • In a 0.9% NaCl solution, red blood cells maintain their normal shape.
  • Hemolysis begins in normal red blood cells at around 0.48% NaCl.
  • Hemolysis begins in spherocytosis at around 0.32% NaCl.
  • Osmotic fragility is increased in spherocytosis.

Learn about the classification and causes of anemia, including the types based on the size of red blood cells and their hemoglobin content. Explore iron deficiency anemia and its impact on the body's oxygen-carrying capacity.

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