ANCA-associated Glomerulonephritis Overview

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What is the commonest form of crescentic or rapidly progressive glomerulonephritis?

ANCA-associated glomerulonephritis (correct)

IgA nephropathy

Membranous nephropathy

Lupus nephritis

What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?

Proliferative glomerulonephritis

Membranous glomerulonephritis

Pauci-immune glomerulonephritis (correct)

Diffuse glomerulonephritis

Which specific antibody reactivity pattern is associated with a serine proteinase called proteinase 3 (PR3)?

Not associated with any specific pattern

Generalized cytoplasmic staining (cANCA) (correct)

Perinuclear pattern (pANCA)

Antigens other than PR3/MPO

In which condition are raised ANCA titres generally detectable during active disease, and rising titres may herald a relapse?

Granulomatosis with polyangiitis Signup and view all the answers

What is the debated role of ANCAs in vasculitis?

Both pathogenic and a marker Signup and view all the answers

Which pattern of ANCA reactivity is associated with a perinuclear pattern (pANCA)?

Generalized cytoplasmic staining (cANCA) Signup and view all the answers

What is the most common form of vasculitic process seen in ANCA-associated glomerulonephritis?

Systemic vasculitic process with pulmonary involvement Signup and view all the answers

What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?

Lack of deposits of immunoglobulin or complement in the kidney Signup and view all the answers

Which condition is associated with some cANCA/pANCA positive sera reacting with neutrophil antigens other than PR3/MPO?

Inflammatory bowel disease Signup and view all the answers

What do rising ANCA titres generally indicate in granulomatosis with polyangiitis?

Heralding a relapse Signup and view all the answers

ANCA-associated Glomerulonephritis Overview

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Questions and Answers

What is the commonest form of crescentic or rapidly progressive glomerulonephritis?

What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?

Which specific antibody reactivity pattern is associated with a serine proteinase called proteinase 3 (PR3)?

In which condition are raised ANCA titres generally detectable during active disease, and rising titres may herald a relapse?

What is the debated role of ANCAs in vasculitis?

Which pattern of ANCA reactivity is associated with a perinuclear pattern (pANCA)?

What is the most common form of vasculitic process seen in ANCA-associated glomerulonephritis?

What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?

Which condition is associated with some cANCA/pANCA positive sera reacting with neutrophil antigens other than PR3/MPO?

What do rising ANCA titres generally indicate in granulomatosis with polyangiitis?

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