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ANCA-associated Glomerulonephritis Overview
10 Questions
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ANCA-associated Glomerulonephritis Overview

Created by
@RefreshedForethought

Questions and Answers

What is the commonest form of crescentic or rapidly progressive glomerulonephritis?

  • ANCA-associated glomerulonephritis (correct)
  • IgA nephropathy
  • Membranous nephropathy
  • Lupus nephritis

    • What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?

  • Proliferative glomerulonephritis
  • Membranous glomerulonephritis
  • Pauci-immune glomerulonephritis (correct)
  • Diffuse glomerulonephritis

    • Which specific antibody reactivity pattern is associated with a serine proteinase called proteinase 3 (PR3)?

  • Not associated with any specific pattern
  • Generalized cytoplasmic staining (cANCA) (correct)
  • Perinuclear pattern (pANCA)
  • Antigens other than PR3/MPO

    • In which condition are raised ANCA titres generally detectable during active disease, and rising titres may herald a relapse?

    <p>Granulomatosis with polyangiitis</p> Signup and view all the answers

    What is the debated role of ANCAs in vasculitis?

    <p>Both pathogenic and a marker</p> Signup and view all the answers

    Which pattern of ANCA reactivity is associated with a perinuclear pattern (pANCA)?

    <p>Generalized cytoplasmic staining (cANCA)</p> Signup and view all the answers

    What is the most common form of vasculitic process seen in ANCA-associated glomerulonephritis?

    <p>Systemic vasculitic process with pulmonary involvement</p> Signup and view all the answers

    What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?

    <p>Lack of deposits of immunoglobulin or complement in the kidney</p> Signup and view all the answers

    Which condition is associated with some cANCA/pANCA positive sera reacting with neutrophil antigens other than PR3/MPO?

    <p>Inflammatory bowel disease</p> Signup and view all the answers

    What do rising ANCA titres generally indicate in granulomatosis with polyangiitis?

    <p>Heralding a relapse</p> Signup and view all the answers

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