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Questions and Answers
What is the commonest form of crescentic or rapidly progressive glomerulonephritis?
What is the commonest form of crescentic or rapidly progressive glomerulonephritis?
- ANCA-associated glomerulonephritis (correct)
- IgA nephropathy
- Membranous nephropathy
- Lupus nephritis
What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?
What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?
- Proliferative glomerulonephritis
- Membranous glomerulonephritis
- Pauci-immune glomerulonephritis (correct)
- Diffuse glomerulonephritis
Which specific antibody reactivity pattern is associated with a serine proteinase called proteinase 3 (PR3)?
Which specific antibody reactivity pattern is associated with a serine proteinase called proteinase 3 (PR3)?
- Not associated with any specific pattern
- Generalized cytoplasmic staining (cANCA) (correct)
- Perinuclear pattern (pANCA)
- Antigens other than PR3/MPO
In which condition are raised ANCA titres generally detectable during active disease, and rising titres may herald a relapse?
In which condition are raised ANCA titres generally detectable during active disease, and rising titres may herald a relapse?
What is the debated role of ANCAs in vasculitis?
What is the debated role of ANCAs in vasculitis?
Which pattern of ANCA reactivity is associated with a perinuclear pattern (pANCA)?
Which pattern of ANCA reactivity is associated with a perinuclear pattern (pANCA)?
What is the most common form of vasculitic process seen in ANCA-associated glomerulonephritis?
What is the most common form of vasculitic process seen in ANCA-associated glomerulonephritis?
What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?
What is the main characteristic of the renal lesion in ANCA-associated glomerulonephritis?
Which condition is associated with some cANCA/pANCA positive sera reacting with neutrophil antigens other than PR3/MPO?
Which condition is associated with some cANCA/pANCA positive sera reacting with neutrophil antigens other than PR3/MPO?
What do rising ANCA titres generally indicate in granulomatosis with polyangiitis?
What do rising ANCA titres generally indicate in granulomatosis with polyangiitis?
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