Lecture 3 - Innate Immune Response
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Questions and Answers

Which of the following is NOT a type of epithelial surface mentioned as a barrier against infection in the text?

  • Gut epithelium
  • Kidney epithelium (correct)
  • Respiratory epithelium
  • Skin

What is the main function of antimicrobial peptides such as Defensins mentioned in the text?

  • Create a friendly environment for microorganisms
  • Destroy microorganisms (correct)
  • Provide protective substances
  • Maintain acidic pH

Which of the following is a function of saliva, hair, mucus, and tears as mentioned in the text?

  • Enhancing microbial growth
  • Creating a friendly environment for pathogens
  • Weakening the body's defense system
  • Providing innate immunity (correct)

Which type of microorganism is E.coli based on the information provided in the text?

<p>Gram negative (D)</p> Signup and view all the answers

What provides the first barrier against infection according to the text?

<p><strong>Skin</strong> (B)</p> Signup and view all the answers

What must a pathogen do to cause an infection according to the text?

<p><strong>Breach one of the barriers</strong> (B)</p> Signup and view all the answers

Which of the following is NOT emphasized as a protective measure provided by epithelial layers in the text?

<p><strong>Hair</strong> (B)</p> Signup and view all the answers

What characteristic of the respiratory tract lining makes it susceptible to entry by airborne microorganisms?

<p><strong>Epithelial layers</strong> (C)</p> Signup and view all the answers

What role do mucosal membranes play in preventing infections according to the text?

<p><strong>Providing innate immunity</strong> (A)</p> Signup and view all the answers

Which cellular elements are responsible for mediating phagocytosis?

<p>Neutrophils &amp; dendritic cells (C)</p> Signup and view all the answers

What is the function of opsonins in phagocytosis?

<p>Enhance phagocytosis by binding to microbial surfaces (A)</p> Signup and view all the answers

What is the primary function of ligands in phagocytosis?

<p>Prompt membrane protrusions for pathogen internalization (B)</p> Signup and view all the answers

Which type of granules in neutrophils aid in attacking microorganisms within phagolysosomes?

<p>Primary granules (D)</p> Signup and view all the answers

What is the main role of antimicrobial enzymes like lysozyme during phagocytosis?

<p>Digest peptidoglycan of pathogens (A)</p> Signup and view all the answers

What is the significance of pseudopodia during the process of phagocytosis?

<p>Extend membrane protrusions for pathogen engulfment (C)</p> Signup and view all the answers

Which cells contain cytoplasmic granules that aid in attacking microorganisms within phagolysosomes?

<p>Neutrophils (A)</p> Signup and view all the answers

What is the primary mechanism employed by phagocytes to damage microbial membranes and intracellular components?

<p>Production of reactive oxygen species (ROS) (A)</p> Signup and view all the answers

Which organelle is highlighted as important for both innate and adaptive immunity processes?

<p>Phagolysosome (A)</p> Signup and view all the answers

What signal do dead or dying cells express to be recognized and engulfed by phagocytes?

<p>'Eat me' signals (A)</p> Signup and view all the answers

What is the role of protein CD47 in the context of phagocytosis?

<p>Inhibit phagocytosis of healthy cells (A)</p> Signup and view all the answers

Which cell type is known for producing neutrophil extracellular traps (NETs) to trap microorganisms?

<p>Neutrophils (A)</p> Signup and view all the answers

What is the primary function of CNS-resident microglia?

<p>Establish proper neuronal connections (D)</p> Signup and view all the answers

In the context of neurological homeostasis & disease, what is a characteristic of multiple sclerosis?

<p>Toxic debris in brain lesion microenvironments (A)</p> Signup and view all the answers

What is the purpose of measuring fluorescence in macrophages in the experimental set-up described?

<p>To determine the impact of different conditions on phagocytosis (B)</p> Signup and view all the answers

'Phagocytosis inhibitors result in higher pH and less fluorescence' - What can be inferred about the relationship between pH levels and phagocytosis?

<p>'Lower pH enhances phagocytosis' (D)</p> Signup and view all the answers

'Neutrophils are not tissue-resident and are always circulating' - How does this continuous circulation benefit immune responses?

<p>Ensures immediate response to any infection at a distant site (A)</p> Signup and view all the answers

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