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Questions and Answers
What are the trade names for amoxicillin/clavulanate?
What are the trade names for amoxicillin/clavulanate?
- Augmentin (correct)
- Augmentin ES 600 (correct)
- Augmentin XR (correct)
- Amocian (correct)
What class does amoxicillin/clavulanate belong to?
What class does amoxicillin/clavulanate belong to?
Aminopenicillin
What is the mechanism of action of amoxicillin/clavulanate?
What is the mechanism of action of amoxicillin/clavulanate?
Inhibits bacteria cell wall synthesis, Beta lactam inhibitor
What are the common indications for using amoxicillin/clavulanate?
What are the common indications for using amoxicillin/clavulanate?
Which of the following are contraindications for amoxicillin/clavulanate?
Which of the following are contraindications for amoxicillin/clavulanate?
What dosage forms are available for amoxicillin/clavulanate?
What dosage forms are available for amoxicillin/clavulanate?
What are the typical doses for amoxicillin/clavulanate?
What are the typical doses for amoxicillin/clavulanate?
The dosage forms of amoxicillin/clavulanate are interchangeable.
The dosage forms of amoxicillin/clavulanate are interchangeable.
What are some common side effects of amoxicillin/clavulanate?
What are some common side effects of amoxicillin/clavulanate?
How should amoxicillin/clavulanate be administered?
How should amoxicillin/clavulanate be administered?
Amoxicillin/clavulanate affects oral contraceptive effectiveness.
Amoxicillin/clavulanate affects oral contraceptive effectiveness.
Is amoxicillin/clavulanate renally eliminated?
Is amoxicillin/clavulanate renally eliminated?
What is the Gram-positive activity of amoxicillin/clavulanate?
What is the Gram-positive activity of amoxicillin/clavulanate?
What is the Gram-negative activity of amoxicillin/clavulanate?
What is the Gram-negative activity of amoxicillin/clavulanate?
What is the activity of amoxicillin/clavulanate against anaerobes?
What is the activity of amoxicillin/clavulanate against anaerobes?
What is the activity of amoxicillin/clavulanate against atypical bacteria?
What is the activity of amoxicillin/clavulanate against atypical bacteria?
What is the importance of amoxicillin/clavulanate?
What is the importance of amoxicillin/clavulanate?
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Study Notes
Amoxicillin/Clavulanate Overview
- Also known as Augmentin, Augmentin ES 600, Augmentin XR, and Amocian.
- Classified as an aminopenicillin.
Mechanism of Action
- Inhibits bacterial cell wall synthesis.
- Functions as a beta-lactam inhibitor.
Common Indications
- Used to treat various bacterial infections.
- Effective for acute otitis media.
- Prescribed for community-acquired pneumonia.
Contraindications and Black Box Warning
- Not safe for individuals with hypersensitivity to amoxicillin, clavulanate, or other beta-lactam antibiotics.
- Contraindicated in patients with severe renal impairment.
Dosage Forms
- Available in tablet and suspension forms.
Dosage Information
- Typical dosing is 875/125 mg twice daily or 500/125 mg two to three times daily.
Important Consideration
- Different dosage forms are not interchangeable.
Side Effects
- May cause nausea, vomiting, diarrhea, or loose stools.
Administration Guidelines
- Should be taken at the start of a meal to enhance absorption.
- May decrease the effectiveness of oral contraceptives.
Renal Elimination
- Yes, amoxicillin/clavulanate is primarily eliminated through the kidneys.
Spectrum of Activity
- Effective against Gram-positive bacteria (positive).
- Strong activity against Gram-negative bacteria (double positive).
- Active against anaerobes (positive).
- Not effective against atypical bacteria (zero).
Clinical Importance
- Amoxicillin/clavulanate offers a broader spectrum of antibiotic activity than amoxicillin alone, thanks to clavulanate, which inhibits the degradation of amoxicillin by beta-lactamases.
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