Amoxicillin/Clavulanate Flashcards

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Questions and Answers

What are the trade names for amoxicillin/clavulanate?

Augmentin (correct)

Augmentin ES 600 (correct)

Augmentin XR (correct)

Amocian (correct)

What class does amoxicillin/clavulanate belong to?

Aminopenicillin

What is the mechanism of action of amoxicillin/clavulanate?

Inhibits bacteria cell wall synthesis, Beta lactam inhibitor

What are the common indications for using amoxicillin/clavulanate?

Community acquired Pneumonia Signup and view all the answers

Which of the following are contraindications for amoxicillin/clavulanate?

Hypersensitivity to clavulanate Signup and view all the answers

What dosage forms are available for amoxicillin/clavulanate?

Tablet Signup and view all the answers

What are the typical doses for amoxicillin/clavulanate?

875/125 BID, 500/125 2-3 times a day Signup and view all the answers

The dosage forms of amoxicillin/clavulanate are interchangeable.

False Signup and view all the answers

What are some common side effects of amoxicillin/clavulanate?

Nausea, vomiting, diarrhea, loose stool Signup and view all the answers

How should amoxicillin/clavulanate be administered?

Take at the start of a meal Signup and view all the answers

Amoxicillin/clavulanate affects oral contraceptive effectiveness.

True Signup and view all the answers

Is amoxicillin/clavulanate renally eliminated?

Yes Signup and view all the answers

What is the Gram-positive activity of amoxicillin/clavulanate?

<ul> <li></li> </ul> Signup and view all the answers

What is the Gram-negative activity of amoxicillin/clavulanate?

++ Signup and view all the answers

What is the activity of amoxicillin/clavulanate against anaerobes?

<ul> <li></li> </ul> Signup and view all the answers

What is the activity of amoxicillin/clavulanate against atypical bacteria?

0 Signup and view all the answers

What is the importance of amoxicillin/clavulanate?

Broader spectrum of antibiotic activity compared to amoxicillin because clavulanate is a beta-lactamase inhibitor that prevents amoxicillin degradation by beta-lactamases. Signup and view all the answers

Study Notes

Amoxicillin/Clavulanate Overview

Also known as Augmentin, Augmentin ES 600, Augmentin XR, and Amocian.
Classified as an aminopenicillin.

Mechanism of Action

Inhibits bacterial cell wall synthesis.
Functions as a beta-lactam inhibitor.

Common Indications

Used to treat various bacterial infections.
Effective for acute otitis media.
Prescribed for community-acquired pneumonia.

Contraindications and Black Box Warning

Not safe for individuals with hypersensitivity to amoxicillin, clavulanate, or other beta-lactam antibiotics.
Contraindicated in patients with severe renal impairment.

Dosage Forms

Available in tablet and suspension forms.

Dosage Information

Typical dosing is 875/125 mg twice daily or 500/125 mg two to three times daily.

Important Consideration

Different dosage forms are not interchangeable.

Side Effects

May cause nausea, vomiting, diarrhea, or loose stools.

Administration Guidelines

Should be taken at the start of a meal to enhance absorption.
May decrease the effectiveness of oral contraceptives.

Renal Elimination

Yes, amoxicillin/clavulanate is primarily eliminated through the kidneys.

Spectrum of Activity

Effective against Gram-positive bacteria (positive).
Strong activity against Gram-negative bacteria (double positive).
Active against anaerobes (positive).
Not effective against atypical bacteria (zero).

Clinical Importance

Amoxicillin/clavulanate offers a broader spectrum of antibiotic activity than amoxicillin alone, thanks to clavulanate, which inhibits the degradation of amoxicillin by beta-lactamases.

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Description

Test your knowledge on Amoxicillin/Clavulanate with these flashcards. This quiz covers definitions, classifications, mechanisms of action, common indications, and contraindications for this important antibiotic medication. Perfect for pharmacology students and healthcare professionals.