5 Questions
Which type of organisms do aminoglycosides have a broad spectrum of activity against?
Mycobacteria
Which of the following are examples of drugs within the aminoglycoside class?
Gentamicin, tobramycin, amikacin
For which condition are aminoglycosides indicated for empiric therapy?
Infective endocarditis
In which type of patients should aminoglycosides be used for empiric therapy?
Patients with severe illness
What is a notable characteristic of aminoglycosides in terms of drug resistance?
They have demonstrated effectiveness in multi-drug resistant Gram-negative pathogens
Study Notes
Aminoglycosides
- Aminoglycosides have a broad spectrum of activity against gram-negative aerobic bacteria, including Pseudomonas aeruginosa.
Examples of Aminoglycosides
- Examples of drugs within the aminoglycoside class include gentamicin, tobramycin, amikacin, and streptomycin.
Indication for Empiric Therapy
- Aminoglycosides are indicated for empiric therapy in severe infections, including sepsis, malignant otitis externa, and endocarditis.
Patient Selection for Empiric Therapy
- Aminoglycosides should be used for empiric therapy in immunocompromised patients, including those with neutropenia or HIV/AIDS.
Notable Characteristic: Drug Resistance
- A notable characteristic of aminoglycosides is that they are minimally affected by beta-lactamases, making them useful against bacteria resistant to beta-lactam antibiotics.
Test your knowledge of aminoglycosides with this quiz. Explore the spectrum of activity, clinical value, and different drugs within this class, such as gentamicin, tobramycin, amikacin, neomycin, plazomicin, paromomycin, and more.
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