Aminoglycosides Antibiotics
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Questions and Answers

What is the mode of action of aminoglycosides?

  • Disruption of cell wall synthesis
  • Prevention of RNA transcription
  • Interference with bacterial protein synthesis (correct)
  • Inhibition of DNA synthesis

Which of the following is NOT a member of the aminoglycoside group of antibiotics?

  • Penicillin (correct)
  • Apramycin
  • Tobramycin
  • Streptomycin

How do aminoglycosides cause cell death in bacteria?

  • By interfering with ribosomal subunits (correct)
  • By damaging the bacterial DNA
  • By preventing RNA synthesis
  • By inhibiting cell wall formation

What effect do aminoglycosides have on cell membrane permeability?

<p>They disrupt the membrane due to abnormal protein channels (C)</p> Signup and view all the answers

Why are aminoglycosides considered bactericidal?

<p>They have an intracellular bactericidal effect (A)</p> Signup and view all the answers

What is the source of beta-lactam antibiotics like cephalosporins?

<p>Obtained from molds of cephalosporium (C)</p> Signup and view all the answers

What is the primary mode of action of beta-lactam antibiotics like cephalosporins?

<p>Inhibit bacterial cell wall synthesis (D)</p> Signup and view all the answers

What is the antibacterial activity of beta-lactam antibiotics like cephalosporins?

<p>Bactericidal on growing cells (A)</p> Signup and view all the answers

What is the spectrum of activity for beta-lactam antibiotics like cephalosporins?

<p>Narrow, mainly active against Gram-positive bacteria (C)</p> Signup and view all the answers

What is a key property of beta-lactam antibiotics like cephalosporins?

<p>Short half-lives (except cefotetan &amp; ceftriaxone) (A)</p> Signup and view all the answers

What is a key advantage of using cephalosporins?

<p>Useful in infections of soft tissue and bone due to bacteria resistant to other antimicrobials (C)</p> Signup and view all the answers

Which of the following is the most toxic aminoglycoside antibiotic?

<p>Neomycin (A)</p> Signup and view all the answers

Which aminoglycoside antibiotic is the least toxic but more expensive?

<p>Amikacin (B)</p> Signup and view all the answers

Which of the following is a common side effect of prolonged administration of aminoglycoside antibiotics?

<p>Neuromuscular blockage (C)</p> Signup and view all the answers

Which aminoglycoside antibiotic is particularly effective against Pseudomonas infections?

<p>Tobramycin (C)</p> Signup and view all the answers

Which of the following is a common use of aminoglycoside antibiotics in poultry?

<p>Prevention of early bacterial infections in chicks (A)</p> Signup and view all the answers

Which combination of aminoglycoside and other antibiotic class is commonly used for the treatment of G-positive mastitis in large animals?

<p>Aminoglycoside + Cephalosporin (B)</p> Signup and view all the answers

What is a possible side effect of cephalosporins when given orally?

<p>Nephrotoxicity (A)</p> Signup and view all the answers

Which antibiotic resistance mechanism involves the production of beta-lactamase?

<p>Most importantly (D)</p> Signup and view all the answers

How do aminoglycosides cause disruption of cell membrane permeability in bacteria?

<p>Formation of abnormal protein channels (D)</p> Signup and view all the answers

Which type of bacteria does methicillin-resistant S. aureus (MRSA) show resistance against?

<p>All beta-lactams except 5th generation (A)</p> Signup and view all the answers

What is the main mode of action of aminoglycosides on bacterial protein synthesis?

<p>Interference with mRNA reading (A)</p> Signup and view all the answers

Which antibiotic enhances the penetration of aminoglycosides by disrupting the cell wall?

<p>Cephalexin (B)</p> Signup and view all the answers

What is the purpose of combining Streptomycin with other aminoglycosides?

<p>To prevent the development of resistance (B)</p> Signup and view all the answers

What is the main mechanism of aminoglycoside resistance?

<p>Modification of the aminoglycoside structure to prevent ribosomal binding (C)</p> Signup and view all the answers

What is the primary mode of action of macrolide antibiotics?

<p>Inhibition of bacterial protein synthesis (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the antibacterial activity of macrolides?

<p>Highly active against most aerobic Gram-negative bacteria (C)</p> Signup and view all the answers

What is the primary reason for the use of enteric-coated tablets for macrolide antibiotics?

<p>To protect the antibiotic from gastric destruction (D)</p> Signup and view all the answers

What is the main route of excretion for macrolides like Tylosin?

<p>Unchanged in urine &amp; bile (D)</p> Signup and view all the answers

Apart from their antibacterial activity, what additional properties do macrolides have?

<p>Anti-inflammatory properties (D)</p> Signup and view all the answers

Which of the following is a therapeutic use of macrolides in large animals?

<p>Treatment of mastitis and pneumonia (A)</p> Signup and view all the answers

What is the drug of choice for treating enteritis caused by Campylobacter jejuni?

<p>Erythromycin (D)</p> Signup and view all the answers

How often is Erythroprim administered when used as a treatment?

<p>Once or twice a day (D)</p> Signup and view all the answers

What makes Erythroprim different from erythromycin?

<p>More active on mycoplasma in poultry (D)</p> Signup and view all the answers

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