Aminoglycosides Antibiotics
34 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the mode of action of aminoglycosides?

  • Disruption of cell wall synthesis
  • Prevention of RNA transcription
  • Interference with bacterial protein synthesis (correct)
  • Inhibition of DNA synthesis

    • Which of the following is NOT a member of the aminoglycoside group of antibiotics?

  • Penicillin (correct)
  • Apramycin
  • Tobramycin
  • Streptomycin

    • How do aminoglycosides cause cell death in bacteria?

  • By interfering with ribosomal subunits (correct)
  • By damaging the bacterial DNA
  • By preventing RNA synthesis
  • By inhibiting cell wall formation

    • What effect do aminoglycosides have on cell membrane permeability?

    <p>They disrupt the membrane due to abnormal protein channels</p> Signup and view all the answers

    Why are aminoglycosides considered bactericidal?

    <p>They have an intracellular bactericidal effect</p> Signup and view all the answers

    What is the source of beta-lactam antibiotics like cephalosporins?

    <p>Obtained from molds of cephalosporium</p> Signup and view all the answers

    What is the primary mode of action of beta-lactam antibiotics like cephalosporins?

    <p>Inhibit bacterial cell wall synthesis</p> Signup and view all the answers

    What is the antibacterial activity of beta-lactam antibiotics like cephalosporins?

    <p>Bactericidal on growing cells</p> Signup and view all the answers

    What is the spectrum of activity for beta-lactam antibiotics like cephalosporins?

    <p>Narrow, mainly active against Gram-positive bacteria</p> Signup and view all the answers

    What is a key property of beta-lactam antibiotics like cephalosporins?

    <p>Short half-lives (except cefotetan &amp; ceftriaxone)</p> Signup and view all the answers

    What is a key advantage of using cephalosporins?

    <p>Useful in infections of soft tissue and bone due to bacteria resistant to other antimicrobials</p> Signup and view all the answers

    Which of the following is the most toxic aminoglycoside antibiotic?

    <p>Neomycin</p> Signup and view all the answers

    Which aminoglycoside antibiotic is the least toxic but more expensive?

    <p>Amikacin</p> Signup and view all the answers

    Which of the following is a common side effect of prolonged administration of aminoglycoside antibiotics?

    <p>Neuromuscular blockage</p> Signup and view all the answers

    Which aminoglycoside antibiotic is particularly effective against Pseudomonas infections?

    <p>Tobramycin</p> Signup and view all the answers

    Which of the following is a common use of aminoglycoside antibiotics in poultry?

    <p>Prevention of early bacterial infections in chicks</p> Signup and view all the answers

    Which combination of aminoglycoside and other antibiotic class is commonly used for the treatment of G-positive mastitis in large animals?

    <p>Aminoglycoside + Cephalosporin</p> Signup and view all the answers

    What is a possible side effect of cephalosporins when given orally?

    <p>Nephrotoxicity</p> Signup and view all the answers

    Which antibiotic resistance mechanism involves the production of beta-lactamase?

    <p>Most importantly</p> Signup and view all the answers

    How do aminoglycosides cause disruption of cell membrane permeability in bacteria?

    <p>Formation of abnormal protein channels</p> Signup and view all the answers

    Which type of bacteria does methicillin-resistant S. aureus (MRSA) show resistance against?

    <p>All beta-lactams except 5th generation</p> Signup and view all the answers

    What is the main mode of action of aminoglycosides on bacterial protein synthesis?

    <p>Interference with mRNA reading</p> Signup and view all the answers

    Which antibiotic enhances the penetration of aminoglycosides by disrupting the cell wall?

    <p>Cephalexin</p> Signup and view all the answers

    What is the purpose of combining Streptomycin with other aminoglycosides?

    <p>To prevent the development of resistance</p> Signup and view all the answers

    What is the main mechanism of aminoglycoside resistance?

    <p>Modification of the aminoglycoside structure to prevent ribosomal binding</p> Signup and view all the answers

    What is the primary mode of action of macrolide antibiotics?

    <p>Inhibition of bacterial protein synthesis</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the antibacterial activity of macrolides?

    <p>Highly active against most aerobic Gram-negative bacteria</p> Signup and view all the answers

    What is the primary reason for the use of enteric-coated tablets for macrolide antibiotics?

    <p>To protect the antibiotic from gastric destruction</p> Signup and view all the answers

    What is the main route of excretion for macrolides like Tylosin?

    <p>Unchanged in urine &amp; bile</p> Signup and view all the answers

    Apart from their antibacterial activity, what additional properties do macrolides have?

    <p>Anti-inflammatory properties</p> Signup and view all the answers

    Which of the following is a therapeutic use of macrolides in large animals?

    <p>Treatment of mastitis and pneumonia</p> Signup and view all the answers

    What is the drug of choice for treating enteritis caused by Campylobacter jejuni?

    <p>Erythromycin</p> Signup and view all the answers

    How often is Erythroprim administered when used as a treatment?

    <p>Once or twice a day</p> Signup and view all the answers

    What makes Erythroprim different from erythromycin?

    <p>More active on mycoplasma in poultry</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser