Podcast Beta
Questions and Answers
Which type of infections are aminoglycosides usually used to treat?
Why are aminoglycosides not given orally?
What adverse reactions are associated with aminoglycosides?
How often are aminoglycosides usually administered to enhance synergy?
Signup and view all the answers
What is the main reason aminoglycosides are not given orally?
Signup and view all the answers
Which adverse reaction associated with aminoglycosides is usually reversible?
Signup and view all the answers
In pediatric population, aminoglycosides are commonly used to treat which of the following conditions?
Signup and view all the answers
What is the primary mechanism of action of aminoglycosides?
Signup and view all the answers
Which of the following is a bactericidal drug that prevents protein synthesis by binding to the 30S ribosome?
Signup and view all the answers
What is the primary reason for not administering aminoglycosides orally?
Signup and view all the answers
Which of the following are commonly monitored with aminoglycoside medications?
Signup and view all the answers
What are the indications for using aminoglycosides in treating infections?
Signup and view all the answers
How often are aminoglycosides usually administered to enhance synergy?
Signup and view all the answers
Which adverse reaction associated with aminoglycosides is usually reversible?
Signup and view all the answers
What is a common adverse reaction associated with aminoglycosides that is not reversible?
Signup and view all the answers
Which of the following is a common adverse reaction associated with aminoglycosides that is usually reversible?
Signup and view all the answers
What is the primary reason aminoglycosides are not given orally?
Signup and view all the answers
How often are aminoglycosides usually administered to enhance synergy?
Signup and view all the answers
Which of the following is a bactericidal drug that prevents protein synthesis by binding to the 30S ribosome?
Signup and view all the answers
In pediatric population, aminoglycosides are commonly used to treat which of the following conditions?
Signup and view all the answers
What adverse reaction associated with aminoglycosides is not reversible and not as common?
Signup and view all the answers
Which type of infections are aminoglycosides usually used to treat?
Signup and view all the answers
Study Notes
Aminoglycosides
- Aminoglycosides are usually used to treat life-threatening infections, particularly those caused by Gram-negative bacteria, such as Pseudomonas aeruginosa and Klebsiella pneumoniae.
- Aminoglycosides are not given orally because they are not well-absorbed from the gastrointestinal tract and may cause gastrointestinal disturbances.
Mechanism of Action and Administration
- The primary mechanism of action of aminoglycosides is to prevent protein synthesis by binding to the 30S ribosome, making them bactericidal.
- Aminoglycosides are usually administered every 8 hours to enhance synergy with other antibiotics.
Adverse Reactions
- Aminoglycosides are associated with adverse reactions such as ototoxicity (hearing loss) and nephrotoxicity (kidney damage).
- Ototoxicity is usually not reversible, while nephrotoxicity is usually reversible.
- Aminoglycosides can also cause neuromuscular blockade, which can lead to respiratory failure.
Pediatric Use and Monitoring
- In pediatric population, aminoglycosides are commonly used to treat meningitis, sepsis, and Pseudomonas infections.
- Peak and trough levels of aminoglycosides, as well as renal function, are commonly monitored during treatment.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge of aminoglycoside antibiotics with this quiz. Learn about their bactericidal action, potency against gram-negative and some gram-positive bacteria, administration route, need for therapeutic drug monitoring, and potential side effects like ototoxicity and nephrotoxicity.
