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Questions and Answers
Which type of infections are aminoglycosides usually used to treat?
Which type of infections are aminoglycosides usually used to treat?
Why are aminoglycosides not given orally?
Why are aminoglycosides not given orally?
What adverse reactions are associated with aminoglycosides?
What adverse reactions are associated with aminoglycosides?
How often are aminoglycosides usually administered to enhance synergy?
How often are aminoglycosides usually administered to enhance synergy?
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What is the main reason aminoglycosides are not given orally?
What is the main reason aminoglycosides are not given orally?
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Which adverse reaction associated with aminoglycosides is usually reversible?
Which adverse reaction associated with aminoglycosides is usually reversible?
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In pediatric population, aminoglycosides are commonly used to treat which of the following conditions?
In pediatric population, aminoglycosides are commonly used to treat which of the following conditions?
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What is the primary mechanism of action of aminoglycosides?
What is the primary mechanism of action of aminoglycosides?
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Which of the following is a bactericidal drug that prevents protein synthesis by binding to the 30S ribosome?
Which of the following is a bactericidal drug that prevents protein synthesis by binding to the 30S ribosome?
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What is the primary reason for not administering aminoglycosides orally?
What is the primary reason for not administering aminoglycosides orally?
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Which of the following are commonly monitored with aminoglycoside medications?
Which of the following are commonly monitored with aminoglycoside medications?
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What are the indications for using aminoglycosides in treating infections?
What are the indications for using aminoglycosides in treating infections?
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How often are aminoglycosides usually administered to enhance synergy?
How often are aminoglycosides usually administered to enhance synergy?
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Which adverse reaction associated with aminoglycosides is usually reversible?
Which adverse reaction associated with aminoglycosides is usually reversible?
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What is a common adverse reaction associated with aminoglycosides that is not reversible?
What is a common adverse reaction associated with aminoglycosides that is not reversible?
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Which of the following is a common adverse reaction associated with aminoglycosides that is usually reversible?
Which of the following is a common adverse reaction associated with aminoglycosides that is usually reversible?
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What is the primary reason aminoglycosides are not given orally?
What is the primary reason aminoglycosides are not given orally?
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How often are aminoglycosides usually administered to enhance synergy?
How often are aminoglycosides usually administered to enhance synergy?
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Which of the following is a bactericidal drug that prevents protein synthesis by binding to the 30S ribosome?
Which of the following is a bactericidal drug that prevents protein synthesis by binding to the 30S ribosome?
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In pediatric population, aminoglycosides are commonly used to treat which of the following conditions?
In pediatric population, aminoglycosides are commonly used to treat which of the following conditions?
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What adverse reaction associated with aminoglycosides is not reversible and not as common?
What adverse reaction associated with aminoglycosides is not reversible and not as common?
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Which type of infections are aminoglycosides usually used to treat?
Which type of infections are aminoglycosides usually used to treat?
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Study Notes
Aminoglycosides
- Aminoglycosides are usually used to treat life-threatening infections, particularly those caused by Gram-negative bacteria, such as Pseudomonas aeruginosa and Klebsiella pneumoniae.
- Aminoglycosides are not given orally because they are not well-absorbed from the gastrointestinal tract and may cause gastrointestinal disturbances.
Mechanism of Action and Administration
- The primary mechanism of action of aminoglycosides is to prevent protein synthesis by binding to the 30S ribosome, making them bactericidal.
- Aminoglycosides are usually administered every 8 hours to enhance synergy with other antibiotics.
Adverse Reactions
- Aminoglycosides are associated with adverse reactions such as ototoxicity (hearing loss) and nephrotoxicity (kidney damage).
- Ototoxicity is usually not reversible, while nephrotoxicity is usually reversible.
- Aminoglycosides can also cause neuromuscular blockade, which can lead to respiratory failure.
Pediatric Use and Monitoring
- In pediatric population, aminoglycosides are commonly used to treat meningitis, sepsis, and Pseudomonas infections.
- Peak and trough levels of aminoglycosides, as well as renal function, are commonly monitored during treatment.
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Description
Test your knowledge of aminoglycoside antibiotics with this quiz. Learn about their bactericidal action, potency against gram-negative and some gram-positive bacteria, administration route, need for therapeutic drug monitoring, and potential side effects like ototoxicity and nephrotoxicity.
