87 Questions
Which medication should be taken with breakfast and dinner?
Galantamine IR
What is the mechanism of action of memantine?
Blocks NMDA receptors
Which formulation of memantine can be mixed with liquid?
Oral solution
What is the starting dose of memantine IR in the combination product Namzaric?
7 mg PO daily
What is the maximum daily dose of memantine for patients with CrCI < 30 ml/min?
5 mg PO BID (IR)
What are the common side effects of memantine?
Dizziness, confusion, headache, constipation, syncope
How should the ER capsule and Namzaric be taken?
Swallowed whole
What is the brand name of the combination product containing memantine and donepezil?
Namzaric
Which medication should be switched to Namzaric if stable on donepezil 10 mg?
Donepezil 10 mg
What does the brand name NaMenDA indicate about the medication?
It has NMDA embedded in the name
Which enzyme do acetylcholinesterase inhibitors inhibit?
Centrally-active acetylcholinesterase
Which drug is a combination of Donepezil and memantine?
Donepezil + memantine (Namzaric)
What is the dosing recommendation for Donepezil + memantine (Namzaric) in moderate-to-severe disease?
Start with 23 mg QHS
What is the dosing recommendation for Rivastigmine (Exelon) in capsule form?
Start with 1.5 mg BID
What is the maximum patch dose for Rivastigmine (Exelon) in patients with hepatic impairment?
4.6 mg/24 hrs
What is the initial dosing recommendation for Galantamine (Razadyne, Razadyne ER) in IR tablet or solution form?
Start with 4 mg BID
What should be avoided in patients with severe hepatic or renal impairment when using Galantamine (Razadyne, Razadyne ER)?
Applying the patch
What are the warnings associated with acetylcholinesterase inhibitors?
Cardiac effects
What are the common side effects of acetylcholinesterase inhibitors?
Nausea
Which acetylcholinesterase inhibitor is dosed QHS to help decrease nausea?
Donepezil (Arlcept)
Acetylcholinesterase inhibitors increase the breakdown of acetylcholine in the brain.
False
Galantamine is available in tablet, capsule, and solution forms.
True
Donepezil is the only acetylcholinesterase inhibitor that should be taken with food.
False
Rivastigmine can be administered through a patch or a capsule.
True
The starting dose of Donepezil + memantine (Namzaric) is 5 mg once daily.
True
Patients with severe hepatic or renal impairment should avoid using Galantamine.
True
Cardiac effects, including bradycardia and syncope, are common side effects of acetylcholinesterase inhibitors.
False
Nausea and diarrhea are common side effects of Donepezil.
True
Exelon patch should be applied to the same site for 14 days before rotating to a new site.
False
Memantine is an acetylcholinesterase inhibitor.
False
True or false: Memantine blocks NMDA receptors, which inhibits glutamate from binding and decreases abnormal neuron activation?
True
True or false: Galantamine IR should be taken with breakfast and dinner, while galantamine ER should be taken with breakfast?
True
True or false: Galantamine solution can be mixed with liquid and should be consumed immediately?
True
True or false: If stable on donepezil 10 mg, it is recommended to switch to Namzaric (memantine 7 mg/donepezil 10 mg QHS) and titrate weekly?
True
True or false: Memantine is available in tablet, capsule, and oral solution forms?
True
True or false: It is possible to switch from memantine IR 10 mg BID to memantine ER 28 mg daily?
True
True or false: The maximum dose of memantine for patients with CrCI < 30 ml/min is 5 mg PO BID (IR) or 14 mg PO daily (ER)?
True
True or false: Caution should be exercised when using memantine with drugs or conditions that increase urine pH, as it may decrease clearance of memantine?
True
True or false: Memantine is generally well-tolerated but can cause side effects such as dizziness, confusion, headache, constipation, and syncope?
True
True or false: ER capsules and Namzaric should not be crushed or chewed, but capsules can be opened and sprinkled on applesauce?
True
What is the mechanism of action of memantine?
Memantine blocks NMDA receptors, which inhibits glutamate from binding and decreases abnormal neuron activation.
What is the dosing recommendation for Galantamine (Razadyne, Razadyne ER) in IR tablet or solution form?
The initial dosing recommendation for Galantamine (Razadyne, Razadyne ER) in IR tablet or solution form is 5 mg PO daily, titrated weekly to 10 mg PO BID.
What is the maximum daily dose of memantine for patients with CrCI < 30 ml/min?
The maximum daily dose of memantine for patients with CrCI < 30 ml/min is 5 mg PO BID (IR) or 14 mg PO daily (ER).
What is the brand name of the combination product containing memantine and donepezil?
The brand name of the combination product containing memantine and donepezil is Namzaric.
What are the warnings associated with acetylcholinesterase inhibitors?
The warnings associated with acetylcholinesterase inhibitors include caution with drugs/conditions that increase urine pH, which decreases clearance of memantine (e.g., sodium bicarbonate, acetazolamide, renal tubular acidosis).
True or false: Galantamine solution can be mixed with liquid and should be consumed immediately?
True
True or false: If stable on donepezil 10 mg, it is recommended to switch to Namzaric (memantine 7 mg/donepezil 10 mg QHS) and titrate weekly?
True
What is the starting dose of memantine IR in the combination product Namzaric?
The starting dose of memantine IR in the combination product Namzaric is 5 mg PO daily, titrated weekly to 10 mg PO BID.
True or false: ER capsules and Namzaric should not be crushed or chewed, but capsules can be opened and sprinkled on applesauce?
True
True or false: Galantamine IR should be taken with breakfast and dinner, while galantamine ER should be taken with breakfast?
True
What is the mechanism of action of acetylcholinesterase inhibitors?
Acetylcholinesterase inhibitors inhibit the enzyme responsible for hydrolysis of acetylcholine, leading to an increase in acetylcholine levels.
What are the generic and brand names of the acetylcholinesterase inhibitor that is a combination of donepezil and memantine?
The generic name is Donepezil + memantine and the brand name is Namzaric.
What is the dosing recommendation for Rivastigmine (Exelon) in capsule form?
The initial dose is 1.5 mg twice daily, which can be increased every 2 weeks to a maximum dose of 6 mg twice daily.
What are the warnings associated with acetylcholinesterase inhibitors?
The warnings include cardiac effects such as bradycardia and syncope, anorexia/weight loss, and rare occurrences of neuroleptic malignant syndrome and rhabdomyolysis.
What are the common side effects of acetylcholinesterase inhibitors?
The common side effects include nausea, diarrhea, insomnia, and decreased appetite/weight loss.
How should the Exelon patch be used?
The Exelon patch should be applied to a new site every 14 days, and the first patch should be applied the day after the last oral dose of Exelon.
What is the starting dose of Galantamine (Razadyne, Razadyne ER) in immediate-release tablet or solution form?
The starting dose is 4 mg twice daily.
What should be avoided in patients with severe hepatic or renal impairment when using Galantamine (Razadyne, Razadyne ER)?
The use of Galantamine should be avoided in patients with severe hepatic or renal impairment.
What is the starting dose of Donepezil (Aricept) orally disintegrating tablet (ODT)?
The starting dose of Donepezil ODT is 4 mg once daily.
What is the maximum patch dose of Rivastigmine (Exelon) in patients with hepatic impairment?
The maximum patch dose in patients with hepatic impairment is 4.6 mg/24 hours.
Match the following medications with their administration instructions:
Exelon capsules and galantamine IR = Taken with breakfast and dinner Galantamine ER = Taken with breakfast Memantine + donepezil (Namzaric) IR = Start with 5 mg PO daily, titrate weekly to 10 mg PO BID Memantine ER = Start with 7 mg PO daily, titrate weekly to 28 mg PO daily
Match the following medications with their forms:
Memantine = Tablet, capsule, oral solution Namzaric = Memantine + donepezil Namenda = Memantine Namenda XR = Memantine
Match the following medications with their maximum dose for CrCI < 30 ml/min:
Memantine IR = 5 mg PO BID Memantine ER = 14 mg PO daily
Match the following medications with their warnings:
Memantine = Caution with drugs/conditions that increases urine pH, which decreases clearance of memantine
Match the following medications with their side effects:
Memantine = Dizziness, confusion, headache, constipation, syncope
Match the following medications with their notes on administration:
ER capsule and Namzaric = Do not crush or chew; capsules can be opened and sprinkled on applesauce Galantamine solution = Can be mixed with liquid; drink immediately
Match the following medications with their mechanism of action:
Memantine = Blocks NMDA receptors, which inhibits glutamate from binding and decreases abnormal neuron activation
Match the following brand names with their embedded drug name:
NaMenDA = NMDA
Match the following medications with their instructions for switching forms:
Memantine IR 10 mg BID = Can switch to Memantine ER 28 mg daily
Match the following medications with their instructions for switching to a combination product:
Donepezil 10 mg = Can switch to Namzaric (memantine 7 mg/donepezil 10 mg QHS) and titrate weekly
Match the following acetylcholinesterase inhibitors with their brand names:
Donepezil = Aricept Donepezil + memantine = Namzaric Rivastigmine = Exelon Galantamine = Razadyne, Razadyne ER
Match the following acetylcholinesterase inhibitors with their initial dosing recommendations:
Donepezil = 5 mg QHS Donepezil + memantine = 5 mg QHS Rivastigmine = 1.5 mg BID Galantamine = 4 mg BID
Match the following acetylcholinesterase inhibitors with their maximum dosing recommendations for patients with hepatic impairment:
Donepezil = No specific recommendation Donepezil + memantine = No specific recommendation Rivastigmine = 4.6 mg/24 hrs Galantamine = Do not use
Match the following acetylcholinesterase inhibitors with the conditions they are used to treat:
Donepezil = Alzheimer's disease Donepezil + memantine = Moderate-to-severe Alzheimer's disease Rivastigmine = Alzheimer's disease Galantamine = Alzheimer's disease
Match the following acetylcholinesterase inhibitors with their common side effects:
Donepezil = Nausea, diarrhea, insomnia, decreased appetite/weight loss Donepezil + memantine = Nausea, diarrhea, insomnia, decreased appetite/weight loss Rivastigmine = Nausea, diarrhea, insomnia, decreased appetite/weight loss Galantamine = Nausea, diarrhea, insomnia, decreased appetite/weight loss
Match the following acetylcholinesterase inhibitors with their administration forms:
Donepezil = ODT, tablet Donepezil + memantine = Tablet Rivastigmine = Capsule, patch Galantamine = Tablet, capsule, solution
Match the acetylcholinesterase inhibitors with their warnings:
Donepezil = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis Donepezil + memantine = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis Rivastigmine = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis Galantamine = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis
Match the acetylcholinesterase inhibitors with their mechanisms of action:
Donepezil = Inhibit acetylcholinesterase Donepezil + memantine = Inhibit acetylcholinesterase Rivastigmine = Inhibit acetylcholinesterase Galantamine = Inhibit acetylcholinesterase
Match the acetylcholinesterase inhibitors with their dosing schedules:
Donepezil = Dosed QHS Donepezil + memantine = Dosed QHS Rivastigmine = Dosed BID Galantamine = Dosed BID
Match the acetylcholinesterase inhibitors with their notes about administration:
Donepezil = Dosed QHS to help decrease nausea Donepezil + memantine = No specific notes Rivastigmine = Patch is changed daily, do not use same site for 14 days Galantamine = No specific notes
Which of the following drugs can potentially reduce the efficacy of acetylcholinesterase inhibitors?
Beta-blockers
Which of the following drugs should be used with caution due to the risk of GI bleeding when taken with acetylcholinesterase inhibitors?
NSAIDs
Which of the following drugs should be used with caution due to their potential to cause dizziness when taken with acetylcholinesterase inhibitors?
Skeletal muscle relaxants
True or false: Acetylcholinesterase inhibitors can reduce the efficacy of drugs with anticholinergic effects?
True
True or false: NSAIDs should be used cautiously with acetylcholinesterase inhibitors due to the risk of GI bleeding?
True
True or false: Discontinuing incontinence drugs is recommended if there is no benefit?
True
Match the following drugs with their interactions when used with acetylcholinesterase inhibitors:
Beta-blockers, diltiazem, verapamil, digoxin = Can lower heart rate Antipsychotics, alpha-blockers, skeletal muscle relaxants, hypnotics, opioids = Can cause dizziness Drugs with anticholinergic effects = Can reduce the efficacy of acetylcholinesterase inhibitors NSAIDs = Can increase risk of GI bleeding due to increased gastric acid secretion
Test your knowledge on Alzheimer's disease drugs! This quiz will cover the mechanism of action and generic and brand names of acetylcholinesterase inhibitors such as Donepezil, Memantine, Rivastigmine, and Galantamine.
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