Alzheimer's Drug Quiz
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Questions and Answers

Which medication should be taken with breakfast and dinner?

  • Galantamine solution
  • Galantamine IR (correct)
  • Exelon capsules
  • Galantamine ER

    • What is the mechanism of action of memantine?

  • Blocks NMDA receptors (correct)
  • Inhibits glutamate binding
  • Increases abnormal neuron activation
  • Decreases abnormal neuron activation

    • Which formulation of memantine can be mixed with liquid?

  • Namzaric
  • Tablet
  • Capsule
  • Oral solution (correct)

    • What is the starting dose of memantine IR in the combination product Namzaric?

    <p>7 mg PO daily</p> Signup and view all the answers

    What is the maximum daily dose of memantine for patients with CrCI < 30 ml/min?

    <p>5 mg PO BID (IR)</p> Signup and view all the answers

    What are the common side effects of memantine?

    <p>Dizziness, confusion, headache, constipation, syncope</p> Signup and view all the answers

    How should the ER capsule and Namzaric be taken?

    <p>Swallowed whole</p> Signup and view all the answers

    What is the brand name of the combination product containing memantine and donepezil?

    <p>Namzaric</p> Signup and view all the answers

    Which medication should be switched to Namzaric if stable on donepezil 10 mg?

    <p>Donepezil 10 mg</p> Signup and view all the answers

    What does the brand name NaMenDA indicate about the medication?

    <p>It has NMDA embedded in the name</p> Signup and view all the answers

    Which enzyme do acetylcholinesterase inhibitors inhibit?

    <p>Centrally-active acetylcholinesterase</p> Signup and view all the answers

    Which drug is a combination of Donepezil and memantine?

    <p>Donepezil + memantine (Namzaric)</p> Signup and view all the answers

    What is the dosing recommendation for Donepezil + memantine (Namzaric) in moderate-to-severe disease?

    <p>Start with 23 mg QHS</p> Signup and view all the answers

    What is the dosing recommendation for Rivastigmine (Exelon) in capsule form?

    <p>Start with 1.5 mg BID</p> Signup and view all the answers

    What is the maximum patch dose for Rivastigmine (Exelon) in patients with hepatic impairment?

    <p>4.6 mg/24 hrs</p> Signup and view all the answers

    What is the initial dosing recommendation for Galantamine (Razadyne, Razadyne ER) in IR tablet or solution form?

    <p>Start with 4 mg BID</p> Signup and view all the answers

    What should be avoided in patients with severe hepatic or renal impairment when using Galantamine (Razadyne, Razadyne ER)?

    <p>Applying the patch</p> Signup and view all the answers

    What are the warnings associated with acetylcholinesterase inhibitors?

    <p>Cardiac effects</p> Signup and view all the answers

    What are the common side effects of acetylcholinesterase inhibitors?

    <p>Nausea</p> Signup and view all the answers

    Which acetylcholinesterase inhibitor is dosed QHS to help decrease nausea?

    <p>Donepezil (Arlcept)</p> Signup and view all the answers

    Acetylcholinesterase inhibitors increase the breakdown of acetylcholine in the brain.

    <p>False</p> Signup and view all the answers

    Galantamine is available in tablet, capsule, and solution forms.

    <p>True</p> Signup and view all the answers

    Donepezil is the only acetylcholinesterase inhibitor that should be taken with food.

    <p>False</p> Signup and view all the answers

    Rivastigmine can be administered through a patch or a capsule.

    <p>True</p> Signup and view all the answers

    The starting dose of Donepezil + memantine (Namzaric) is 5 mg once daily.

    <p>True</p> Signup and view all the answers

    Patients with severe hepatic or renal impairment should avoid using Galantamine.

    <p>True</p> Signup and view all the answers

    Cardiac effects, including bradycardia and syncope, are common side effects of acetylcholinesterase inhibitors.

    <p>False</p> Signup and view all the answers

    Nausea and diarrhea are common side effects of Donepezil.

    <p>True</p> Signup and view all the answers

    Exelon patch should be applied to the same site for 14 days before rotating to a new site.

    <p>False</p> Signup and view all the answers

    Memantine is an acetylcholinesterase inhibitor.

    <p>False</p> Signup and view all the answers

    True or false: Memantine blocks NMDA receptors, which inhibits glutamate from binding and decreases abnormal neuron activation?

    <p>True</p> Signup and view all the answers

    True or false: Galantamine IR should be taken with breakfast and dinner, while galantamine ER should be taken with breakfast?

    <p>True</p> Signup and view all the answers

    True or false: Galantamine solution can be mixed with liquid and should be consumed immediately?

    <p>True</p> Signup and view all the answers

    True or false: If stable on donepezil 10 mg, it is recommended to switch to Namzaric (memantine 7 mg/donepezil 10 mg QHS) and titrate weekly?

    <p>True</p> Signup and view all the answers

    True or false: Memantine is available in tablet, capsule, and oral solution forms?

    <p>True</p> Signup and view all the answers

    True or false: It is possible to switch from memantine IR 10 mg BID to memantine ER 28 mg daily?

    <p>True</p> Signup and view all the answers

    True or false: The maximum dose of memantine for patients with CrCI < 30 ml/min is 5 mg PO BID (IR) or 14 mg PO daily (ER)?

    <p>True</p> Signup and view all the answers

    True or false: Caution should be exercised when using memantine with drugs or conditions that increase urine pH, as it may decrease clearance of memantine?

    <p>True</p> Signup and view all the answers

    True or false: Memantine is generally well-tolerated but can cause side effects such as dizziness, confusion, headache, constipation, and syncope?

    <p>True</p> Signup and view all the answers

    True or false: ER capsules and Namzaric should not be crushed or chewed, but capsules can be opened and sprinkled on applesauce?

    <p>True</p> Signup and view all the answers

    What is the mechanism of action of memantine?

    <p>Memantine blocks NMDA receptors, which inhibits glutamate from binding and decreases abnormal neuron activation.</p> Signup and view all the answers

    What is the dosing recommendation for Galantamine (Razadyne, Razadyne ER) in IR tablet or solution form?

    <p>The initial dosing recommendation for Galantamine (Razadyne, Razadyne ER) in IR tablet or solution form is 5 mg PO daily, titrated weekly to 10 mg PO BID.</p> Signup and view all the answers

    What is the maximum daily dose of memantine for patients with CrCI < 30 ml/min?

    <p>The maximum daily dose of memantine for patients with CrCI &lt; 30 ml/min is 5 mg PO BID (IR) or 14 mg PO daily (ER).</p> Signup and view all the answers

    What is the brand name of the combination product containing memantine and donepezil?

    <p>The brand name of the combination product containing memantine and donepezil is Namzaric.</p> Signup and view all the answers

    What are the warnings associated with acetylcholinesterase inhibitors?

    <p>The warnings associated with acetylcholinesterase inhibitors include caution with drugs/conditions that increase urine pH, which decreases clearance of memantine (e.g., sodium bicarbonate, acetazolamide, renal tubular acidosis).</p> Signup and view all the answers

    True or false: Galantamine solution can be mixed with liquid and should be consumed immediately?

    <p>True</p> Signup and view all the answers

    True or false: If stable on donepezil 10 mg, it is recommended to switch to Namzaric (memantine 7 mg/donepezil 10 mg QHS) and titrate weekly?

    <p>True</p> Signup and view all the answers

    What is the starting dose of memantine IR in the combination product Namzaric?

    <p>The starting dose of memantine IR in the combination product Namzaric is 5 mg PO daily, titrated weekly to 10 mg PO BID.</p> Signup and view all the answers

    True or false: ER capsules and Namzaric should not be crushed or chewed, but capsules can be opened and sprinkled on applesauce?

    <p>True</p> Signup and view all the answers

    True or false: Galantamine IR should be taken with breakfast and dinner, while galantamine ER should be taken with breakfast?

    <p>True</p> Signup and view all the answers

    What is the mechanism of action of acetylcholinesterase inhibitors?

    <p>Acetylcholinesterase inhibitors inhibit the enzyme responsible for hydrolysis of acetylcholine, leading to an increase in acetylcholine levels.</p> Signup and view all the answers

    What are the generic and brand names of the acetylcholinesterase inhibitor that is a combination of donepezil and memantine?

    <p>The generic name is Donepezil + memantine and the brand name is Namzaric.</p> Signup and view all the answers

    What is the dosing recommendation for Rivastigmine (Exelon) in capsule form?

    <p>The initial dose is 1.5 mg twice daily, which can be increased every 2 weeks to a maximum dose of 6 mg twice daily.</p> Signup and view all the answers

    What are the warnings associated with acetylcholinesterase inhibitors?

    <p>The warnings include cardiac effects such as bradycardia and syncope, anorexia/weight loss, and rare occurrences of neuroleptic malignant syndrome and rhabdomyolysis.</p> Signup and view all the answers

    What are the common side effects of acetylcholinesterase inhibitors?

    <p>The common side effects include nausea, diarrhea, insomnia, and decreased appetite/weight loss.</p> Signup and view all the answers

    How should the Exelon patch be used?

    <p>The Exelon patch should be applied to a new site every 14 days, and the first patch should be applied the day after the last oral dose of Exelon.</p> Signup and view all the answers

    What is the starting dose of Galantamine (Razadyne, Razadyne ER) in immediate-release tablet or solution form?

    <p>The starting dose is 4 mg twice daily.</p> Signup and view all the answers

    What should be avoided in patients with severe hepatic or renal impairment when using Galantamine (Razadyne, Razadyne ER)?

    <p>The use of Galantamine should be avoided in patients with severe hepatic or renal impairment.</p> Signup and view all the answers

    What is the starting dose of Donepezil (Aricept) orally disintegrating tablet (ODT)?

    <p>The starting dose of Donepezil ODT is 4 mg once daily.</p> Signup and view all the answers

    What is the maximum patch dose of Rivastigmine (Exelon) in patients with hepatic impairment?

    <p>The maximum patch dose in patients with hepatic impairment is 4.6 mg/24 hours.</p> Signup and view all the answers

    Match the following medications with their administration instructions:

    <p>Exelon capsules and galantamine IR = Taken with breakfast and dinner Galantamine ER = Taken with breakfast Memantine + donepezil (Namzaric) IR = Start with 5 mg PO daily, titrate weekly to 10 mg PO BID Memantine ER = Start with 7 mg PO daily, titrate weekly to 28 mg PO daily</p> Signup and view all the answers

    Match the following medications with their forms:

    <p>Memantine = Tablet, capsule, oral solution Namzaric = Memantine + donepezil Namenda = Memantine Namenda XR = Memantine</p> Signup and view all the answers

    Match the following medications with their maximum dose for CrCI < 30 ml/min:

    <p>Memantine IR = 5 mg PO BID Memantine ER = 14 mg PO daily</p> Signup and view all the answers

    Match the following medications with their warnings:

    <p>Memantine = Caution with drugs/conditions that increases urine pH, which decreases clearance of memantine</p> Signup and view all the answers

    Match the following medications with their side effects:

    <p>Memantine = Dizziness, confusion, headache, constipation, syncope</p> Signup and view all the answers

    Match the following medications with their notes on administration:

    <p>ER capsule and Namzaric = Do not crush or chew; capsules can be opened and sprinkled on applesauce Galantamine solution = Can be mixed with liquid; drink immediately</p> Signup and view all the answers

    Match the following medications with their mechanism of action:

    <p>Memantine = Blocks NMDA receptors, which inhibits glutamate from binding and decreases abnormal neuron activation</p> Signup and view all the answers

    Match the following brand names with their embedded drug name:

    <p>NaMenDA = NMDA</p> Signup and view all the answers

    Match the following medications with their instructions for switching forms:

    <p>Memantine IR 10 mg BID = Can switch to Memantine ER 28 mg daily</p> Signup and view all the answers

    Match the following medications with their instructions for switching to a combination product:

    <p>Donepezil 10 mg = Can switch to Namzaric (memantine 7 mg/donepezil 10 mg QHS) and titrate weekly</p> Signup and view all the answers

    Match the following acetylcholinesterase inhibitors with their brand names:

    <p>Donepezil = Aricept Donepezil + memantine = Namzaric Rivastigmine = Exelon Galantamine = Razadyne, Razadyne ER</p> Signup and view all the answers

    Match the following acetylcholinesterase inhibitors with their initial dosing recommendations:

    <p>Donepezil = 5 mg QHS Donepezil + memantine = 5 mg QHS Rivastigmine = 1.5 mg BID Galantamine = 4 mg BID</p> Signup and view all the answers

    Match the following acetylcholinesterase inhibitors with their maximum dosing recommendations for patients with hepatic impairment:

    <p>Donepezil = No specific recommendation Donepezil + memantine = No specific recommendation Rivastigmine = 4.6 mg/24 hrs Galantamine = Do not use</p> Signup and view all the answers

    Match the following acetylcholinesterase inhibitors with the conditions they are used to treat:

    <p>Donepezil = Alzheimer's disease Donepezil + memantine = Moderate-to-severe Alzheimer's disease Rivastigmine = Alzheimer's disease Galantamine = Alzheimer's disease</p> Signup and view all the answers

    Match the following acetylcholinesterase inhibitors with their common side effects:

    <p>Donepezil = Nausea, diarrhea, insomnia, decreased appetite/weight loss Donepezil + memantine = Nausea, diarrhea, insomnia, decreased appetite/weight loss Rivastigmine = Nausea, diarrhea, insomnia, decreased appetite/weight loss Galantamine = Nausea, diarrhea, insomnia, decreased appetite/weight loss</p> Signup and view all the answers

    Match the following acetylcholinesterase inhibitors with their administration forms:

    <p>Donepezil = ODT, tablet Donepezil + memantine = Tablet Rivastigmine = Capsule, patch Galantamine = Tablet, capsule, solution</p> Signup and view all the answers

    Match the acetylcholinesterase inhibitors with their warnings:

    <p>Donepezil = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis Donepezil + memantine = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis Rivastigmine = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis Galantamine = Cardiac effects, anorexia/weight loss, neuroleptic malignancy syndrome, rhabdomyolysis</p> Signup and view all the answers

    Match the acetylcholinesterase inhibitors with their mechanisms of action:

    <p>Donepezil = Inhibit acetylcholinesterase Donepezil + memantine = Inhibit acetylcholinesterase Rivastigmine = Inhibit acetylcholinesterase Galantamine = Inhibit acetylcholinesterase</p> Signup and view all the answers

    Match the acetylcholinesterase inhibitors with their dosing schedules:

    <p>Donepezil = Dosed QHS Donepezil + memantine = Dosed QHS Rivastigmine = Dosed BID Galantamine = Dosed BID</p> Signup and view all the answers

    Match the acetylcholinesterase inhibitors with their notes about administration:

    <p>Donepezil = Dosed QHS to help decrease nausea Donepezil + memantine = No specific notes Rivastigmine = Patch is changed daily, do not use same site for 14 days Galantamine = No specific notes</p> Signup and view all the answers

    Which of the following drugs can potentially reduce the efficacy of acetylcholinesterase inhibitors?

    <p>Beta-blockers</p> Signup and view all the answers

    Which of the following drugs should be used with caution due to the risk of GI bleeding when taken with acetylcholinesterase inhibitors?

    <p>NSAIDs</p> Signup and view all the answers

    Which of the following drugs should be used with caution due to their potential to cause dizziness when taken with acetylcholinesterase inhibitors?

    <p>Skeletal muscle relaxants</p> Signup and view all the answers

    True or false: Acetylcholinesterase inhibitors can reduce the efficacy of drugs with anticholinergic effects?

    <p>True</p> Signup and view all the answers

    True or false: NSAIDs should be used cautiously with acetylcholinesterase inhibitors due to the risk of GI bleeding?

    <p>True</p> Signup and view all the answers

    True or false: Discontinuing incontinence drugs is recommended if there is no benefit?

    <p>True</p> Signup and view all the answers

    Match the following drugs with their interactions when used with acetylcholinesterase inhibitors:

    <p>Beta-blockers, diltiazem, verapamil, digoxin = Can lower heart rate Antipsychotics, alpha-blockers, skeletal muscle relaxants, hypnotics, opioids = Can cause dizziness Drugs with anticholinergic effects = Can reduce the efficacy of acetylcholinesterase inhibitors NSAIDs = Can increase risk of GI bleeding due to increased gastric acid secretion</p> Signup and view all the answers

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