Podcast
Questions and Answers
What is the role of acetylcholine (ACh) in Alzheimer's Disease progression?
What is the role of acetylcholine (ACh) in Alzheimer's Disease progression?
- It catalyzes the hydrolysis of choline to acetic acid
- It is closely associated with early cognitive decline (correct)
- It leads to beta-amyloid protein aggregation
- It is responsible for mitochondrial damage in neurons
Which process results in the hydrolysis of acetylcholine to choline and acetic acid?
Which process results in the hydrolysis of acetylcholine to choline and acetic acid?
- Acetylcholinesterase catalysis (correct)
- Neuroinflammation
- Beta-amyloid protein aggregation
- Cation binding to tryptophan residue
Why is acetylcholine (ACh) highly prone to hydrolysis?
Why is acetylcholine (ACh) highly prone to hydrolysis?
- It has an electron-deficient carbon (correct)
- It has a positively charged nitrogen
- It forms cation-pi interactions
- It interacts with serine amino acid residues
Which neurotransmitter is depleted in Alzheimer's Disease?
Which neurotransmitter is depleted in Alzheimer's Disease?
What is the primary function of acetylcholinesterase (AChE) in the context of Alzheimer's Disease?
What is the primary function of acetylcholinesterase (AChE) in the context of Alzheimer's Disease?
Which amino acid residue acts as a base and removes a proton during the hydrolysis process of acetylcholine by acetylcholinesterase?
Which amino acid residue acts as a base and removes a proton during the hydrolysis process of acetylcholine by acetylcholinesterase?
Which medication acts on the glutamatergic system by blocking NMDA receptors?
Which medication acts on the glutamatergic system by blocking NMDA receptors?
Which medication is a potent allosteric potentiating ligand of human nicotinic acetylcholine receptors?
Which medication is a potent allosteric potentiating ligand of human nicotinic acetylcholine receptors?
Which medication is a centrally acting reversible acetylcholinesterase inhibitor with CNS selectivity?
Which medication is a centrally acting reversible acetylcholinesterase inhibitor with CNS selectivity?
Which medication is obtained synthetically or from the bulbs and flowers of Galanthus caucasicus?
Which medication is obtained synthetically or from the bulbs and flowers of Galanthus caucasicus?
Which medication shows weak competitive and reversible cholinesterase inhibition in all areas of the body?
Which medication shows weak competitive and reversible cholinesterase inhibition in all areas of the body?
Which medication is used for the treatment of mild to moderate Alzheimer's disease and memory impairments of vascular origin?
Which medication is used for the treatment of mild to moderate Alzheimer's disease and memory impairments of vascular origin?
Which class of drugs is commonly used to treat Alzheimer's Disease (AD)?
Which class of drugs is commonly used to treat Alzheimer's Disease (AD)?
What is the primary cognitive function affected by Alzheimer's Disease (AD)?
What is the primary cognitive function affected by Alzheimer's Disease (AD)?
Which of the following is NOT a non-cognitive function often affected by Alzheimer's Disease (AD)?
Which of the following is NOT a non-cognitive function often affected by Alzheimer's Disease (AD)?
What type of drugs are carbamate cholinesterase inhibitors?
What type of drugs are carbamate cholinesterase inhibitors?
What is the most common single cause of dementia in the ageing society?
What is the most common single cause of dementia in the ageing society?
What is the main function of anticholinesterases in alleviating symptoms of Alzheimer's Disease?
What is the main function of anticholinesterases in alleviating symptoms of Alzheimer's Disease?
What is the significance of the carbamate group in AChE inhibitors like Rivastigmine?
What is the significance of the carbamate group in AChE inhibitors like Rivastigmine?
Why is Rivastigmine considered a 'pseudo-irreversible' AChE inhibitor?
Why is Rivastigmine considered a 'pseudo-irreversible' AChE inhibitor?
Why is Neostigmine preferred over Miotine despite both drugs being developed to address 'miotine problems'?
Why is Neostigmine preferred over Miotine despite both drugs being developed to address 'miotine problems'?
How do nerve agents cause death?
How do nerve agents cause death?
What is one reason for the limited medicinal use of physostigmine?
What is one reason for the limited medicinal use of physostigmine?
Why are benzene rings considered important in AChE inhibitors like Carbamates?
Why are benzene rings considered important in AChE inhibitors like Carbamates?
'Smart drugs' are often associated with which class of compounds despite lacking evidence of general memory improvement?
'Smart drugs' are often associated with which class of compounds despite lacking evidence of general memory improvement?
What is the role of tertiary nitrogen in AChE inhibitors such as Rivastigmine?
What is the role of tertiary nitrogen in AChE inhibitors such as Rivastigmine?
What effect does Rivastigmine have on plasma proteins?
What effect does Rivastigmine have on plasma proteins?
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