Alzheimer's Drug Treatment Overview

<p>Discontinue drugs that can worsen dementia</p> Signup and view all the answers

<p>Start an acetylcholinesterase inhibitor</p> Signup and view all the answers

<p>All of the above</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>Acetylcholinesterase inhibitors (e.g., donepezil)</p> Signup and view all the answers

<p>Nausea, diarrhea, dizziness</p> Signup and view all the answers

<p>If there is no improvement or if side effects are intolerable</p> Signup and view all the answers

<p>Step 1: Non-Drug Interventions to Keep the Brain Healthy, Step 2: Drug Treatment: Mild-Moderate Alzheimer's Disease, Step 3: Disease Worsens</p> Signup and view all the answers

<p>Nausea, diarrhea, and dizziness</p> Signup and view all the answers

<p>Antipsychotics are used off-label for delusions and agitation</p> Signup and view all the answers

<p>Acetylcholinesterase inhibitors = Mainstay of treatment, used alone or with memantine Memantine (Namenda) = Used alone or with donepezil for moderate-to-severe disease Namzaric = Combination of donepezil and memantine Antidepressants (e.g., sertraline, citalopram, escitalopram) = Used to treat related depression and anxiety</p> Signup and view all the answers

<p>Acetylcholinesterase inhibitors = Can cause nausea, diarrhea, dizziness and should be monitored for both improvement and side effects Donepezil = Taken at bedtime to reduce nausea Memantine (Namenda) = Approved for use alone or with donepezil for moderate-to-severe disease Antidepressants (e.g., sertraline, citalopram, escitalopram) = Used to treat related depression and anxiety</p> Signup and view all the answers

<p>Patients stabilized on this medication can be switched to Namzaric = Donepezil This is a combination of donepezil and memantine = Namzaric These are used alone or with memantine in more advanced stages of the disease = Acetylcholinesterase inhibitors These can be used to treat related depression and anxiety = Antidepressants (e.g., sertraline, citalopram, escitalopram)</p> Signup and view all the answers

<p>Step 1 = Non-drug interventions like exercise, healthy diet, controlling blood glucose, blood pressure and cholesterol, and brain-stimulating activities Step 2 = Drug treatment starting with an acetylcholinesterase Inhibitor for mild-moderate Alzheimer's Disease, and adding memantine for moderate-severe Alzheimer's Disease Step 3 = Use combination treatment of acetylcholinesterase inhibitor + memantine when disease worsens</p> Signup and view all the answers

<p>Mild-Moderate = Start an acetylcholinesterase Inhibitor (donepezil, rivastigmine, galantamine) Moderate-Severe = Start an acetylcholinesterase Inhibitor (donepezil, rivastigmine, galantamine) and/or memantine</p> Signup and view all the answers

<p>Acetylcholinesterase inhibitors = Mainstay of treatment, used in all stages of the disease Memantine = Used alone or in combination with acetylcholinesterase inhibitors, more likely to delay the progression of disease than monotherapy Antipsychotics = Used off-label for delusions and agitation, but with an increased risk of death in elderly patients</p> Signup and view all the answers