10 Questions
What is the mechanism of action of Aducanumab?
Bind to the N-terminus of AB (residues 3-7)
What is the benefit of Aducanumab in clinical trials?
Reduced amyloid beta plaques
What is the current status of Aducanumab?
Approved by FDA for mild AD
What is the mechanism of action of Lecanemab?
Recognize protofibrils and prevent amyloid beta deposition
What is the current status of Lecanemab?
FDA approval in July 2023
What is the benefit of Lecanemab in clinical trials?
Reduced amyloid beta plaques
What is the mechanism of action of Domanemab?
Target the soluble and insoluble plaque build up
What is the current status of Domanemab?
In review by FDA
What is the benefit of Domanemab in clinical trials?
Slowed the pace of AD by 35%
What is a common side effect of Aducanumab?
Amyloid related imaging abnormalities (ARIA)
Test your knowledge on Alzheimer's disease, including the cholinergic hypothesis, Ach neurotransmission, and current treatment options such as AchE inhibitors and NMDA antagonists. Learn about the effects of AChE inhibition and popular medications like Tacrine, Donepezil, and Galantamine.
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