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Questions and Answers
What is the mechanism of action of Aducanumab?
What is the mechanism of action of Aducanumab?
- Bind to soluble monomeric AB
- Prevent AB from being processed into plaques
- Inhibit AChE enzyme
- Bind to the N-terminus of AB (residues 3-7) (correct)
What is the benefit of Aducanumab in clinical trials?
What is the benefit of Aducanumab in clinical trials?
- Increased risk of ARIA
- Reduced amyloid beta plaques (correct)
- Improved cognitive function
- Increased risk of cerebral oedema
What is the current status of Aducanumab?
What is the current status of Aducanumab?
- Rejected by FDA
- Approved for phase 3 trials
- Discontinued in 2024
- Approved by FDA for mild AD (correct)
What is the mechanism of action of Lecanemab?
What is the mechanism of action of Lecanemab?
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What is the current status of Lecanemab?
What is the current status of Lecanemab?
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What is the benefit of Lecanemab in clinical trials?
What is the benefit of Lecanemab in clinical trials?
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What is the mechanism of action of Domanemab?
What is the mechanism of action of Domanemab?
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What is the current status of Domanemab?
What is the current status of Domanemab?
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What is the benefit of Domanemab in clinical trials?
What is the benefit of Domanemab in clinical trials?
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What is a common side effect of Aducanumab?
What is a common side effect of Aducanumab?
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