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Alzheimer's Disease: Cholinergic Hypothesis and Treatment

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Alzheimer's Disease: Cholinergic Hypothesis and Treatment

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Questions and Answers

What is the mechanism of action of Aducanumab?

Bind to soluble monomeric AB

Prevent AB from being processed into plaques

Inhibit AChE enzyme

Bind to the N-terminus of AB (residues 3-7) (correct)

What is the benefit of Aducanumab in clinical trials?

Increased risk of ARIA

Reduced amyloid beta plaques (correct)

Improved cognitive function

Increased risk of cerebral oedema

What is the current status of Aducanumab?

Rejected by FDA

Approved for phase 3 trials

Discontinued in 2024

Approved by FDA for mild AD (correct)

What is the mechanism of action of Lecanemab?

Recognize protofibrils and prevent amyloid beta deposition Signup and view all the answers

What is the current status of Lecanemab?

FDA approval in July 2023 Signup and view all the answers

What is the benefit of Lecanemab in clinical trials?

Reduced amyloid beta plaques Signup and view all the answers

What is the mechanism of action of Domanemab?

Target the soluble and insoluble plaque build up Signup and view all the answers

What is the current status of Domanemab?

In review by FDA Signup and view all the answers

What is the benefit of Domanemab in clinical trials?

Slowed the pace of AD by 35% Signup and view all the answers

What is a common side effect of Aducanumab?

Amyloid related imaging abnormalities (ARIA) Signup and view all the answers