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Alzheimer's Disease Causative Pathway and Current Clinical Trials

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Alzheimer's Disease Causative Pathway and Current Clinical Trials

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Questions and Answers

What is a major issue contributing to the lack of success in Alzheimer's disease clinical trials?

Difficulty in designing appropriate clinical trials (correct)

Too many participants in the trials

Overwhelming success of previous clinical trials

Lack of funding for clinical trials

Which type of therapy focuses on targeting tau in Alzheimer's disease?

Microglia activation therapy

Solanezumab

Gantenerumab (correct)

Anti-Aβ antibodies

What was the outcome of the clinical trials with Solanezumab and Gantenerumab?

Only Solanezumab showed positive results

Both drugs showed significant improvement in cognitive decline

Neither drug demonstrated significant benefits (correct)

Only Gantenerumab showed positive results

Why do researchers face challenges in designing clinical trials for Alzheimer's disease therapies?

Variability in disease progression and diagnosis Signup and view all the answers

What is a common focus of therapeutic approaches for addressing Alzheimer's disease?

Targeting neuroinflammation pathways Signup and view all the answers

What are the key therapeutic targets for Alzheimer's disease pathology?

Aβ antibodies Signup and view all the answers

Which drug is a non-competitive antagonist at NMDA, 5HT3, and nicotinic acetylcholine receptors?

Memantine Signup and view all the answers

What is the mode of action of Solanezumab in Alzheimer's disease?

Anti-Aβ antibodies Signup and view all the answers

Gantenerumab primarily targets which aspect of Alzheimer's disease pathology?

Aβ plaques Signup and view all the answers

Which treatment option aims to reduce glutamate excitotoxicity in Alzheimer's disease?

Memantine Signup and view all the answers

What is a common feature of Phase II and III trials for Alzheimer's disease treatments?

Targeting disease pathomechanisms Signup and view all the answers

What do tau tangles correlate better with, in terms of cognitive dysfunction, compared to plaques?

Memory impairment Signup and view all the answers

What is the primary focus of Aβ immunotherapies?

Neutralizing the target to prevent aggregation Signup and view all the answers

What is the main purpose of attracting immune cells in Aβ immunotherapies?

To degrade Aβ through microglia Signup and view all the answers

In what phase of clinical trials are anti-Aβ antibodies like Solanezumab and Gantenerumab commonly evaluated?

Phase II and III trials Signup and view all the answers

Which of the following is NOT a proposed mechanism of action for Aβ immunotherapies?

Reducing tau tangles formation Signup and view all the answers

What is the key difference between an active and passive immunization approach to Aβ immunotherapies?

Passive immunization stimulates antibody production, while active directly treats with antibodies. Signup and view all the answers