Podcast
Questions and Answers
What is the primary motor sign of Parkinson's disease?
What is the primary motor sign of Parkinson's disease?
- Sleep problems
- Cognitive decline
- Olfactory dysfunction
- Tremor of the hands, arms, legs, jaw, and face (correct)
What is a non-motor sign of Parkinson's disease?
What is a non-motor sign of Parkinson's disease?
- Stiffness of the limbs and trunk
- Bradykinesia or slowness of movement
- Constipation (correct)
- Impaired balance and coordination
What is the pathological hallmark of Parkinson's disease?
What is the pathological hallmark of Parkinson's disease?
- Alpha-synuclein aggregation
- Formation and activity of dopamine
- Olfactory dysfunction
- Lewy bodies in neurons (correct)
Which brain region is primarily affected by the death of dopamine-generating cells in Parkinson's disease?
Which brain region is primarily affected by the death of dopamine-generating cells in Parkinson's disease?
What is the role of alpha-synuclein in Parkinson's disease?
What is the role of alpha-synuclein in Parkinson's disease?
How do the Lewy bodies' distribution correlate with Parkinsonian symptoms?
How do the Lewy bodies' distribution correlate with Parkinsonian symptoms?
What is the primary causative agent according to the majority of researchers?
What is the primary causative agent according to the majority of researchers?
Which gene mutations can cause early onset Alzheimer's disease?
Which gene mutations can cause early onset Alzheimer's disease?
What structure collapses due to tau changes in Alzheimer's disease?
What structure collapses due to tau changes in Alzheimer's disease?
What is the role of beta-secretase in Alzheimer's disease development?
What is the role of beta-secretase in Alzheimer's disease development?
Which protein helps stabilize microtubules in neurons?
Which protein helps stabilize microtubules in neurons?
What is the main hypothesis that links amyloid-β accumulation to Alzheimer's disease?
What is the main hypothesis that links amyloid-β accumulation to Alzheimer's disease?
What is the most common form of dementia prevalent in the elderly?
What is the most common form of dementia prevalent in the elderly?
Which neurotransmitter is proposed by the cholinergic hypothesis to have reduced synthesis in Alzheimer's Disease?
Which neurotransmitter is proposed by the cholinergic hypothesis to have reduced synthesis in Alzheimer's Disease?
What results from the overproduction and reduced clearance of Beta amyloid in Alzheimer's Disease?
What results from the overproduction and reduced clearance of Beta amyloid in Alzheimer's Disease?
Which protein is derived from amyloid precursor protein (APP) and is implicated in Alzheimer's Disease?
Which protein is derived from amyloid precursor protein (APP) and is implicated in Alzheimer's Disease?
What role does acetylcholine play in learning and memory?
What role does acetylcholine play in learning and memory?
What leads to memory impairments according to the cholinergic hypothesis?
What leads to memory impairments according to the cholinergic hypothesis?
