18 Questions
What is the main immune mechanism involved in Cell-Mediated (Delayed) Hypersensitivity?
Interaction between sensitized T lymphocytes & specific antigens
Which type of T lymphocytes are involved in activating macrophages during Cell-Mediated (Delayed) Hypersensitivity?
CD4+ Th1 cells
Which of the following microbes is NOT a major immune response target in delayed type hypersensitivity reactions?
Streptococcus pyogenes
What is the time frame for the development of Cell-Mediated (Delayed) Hypersensitivity reactions?
Within 1-2 days
Which component plays NO role in Cell-Mediated (Delayed) Hypersensitivity reactions?
Antibodies
What is the main function of CD8+ CTLs in Cell-Mediated (Delayed) Hypersensitivity?
Directly kill infected cells
What type of cells are involved in the immunological features of Allergic contact dermatitis?
Langerhans cells
Which type of hypersensitivity reaction is indicative of Allergic contact dermatitis?
Type 4 HS
How is the diagnosis of Allergic contact dermatitis confirmed?
History and patch test
What is the characteristic feature of the acute form of allergic contact dermatitis?
Erythema, oedema, vesiculation
Which parts of the body can provide a clue for diagnosing Allergic contact dermatitis based on the site of the lesion?
Ear lobes, around neck, wrist
What is the main purpose of a patch test in diagnosing Allergic contact dermatitis?
To place a low dose of suspected Ag(s) on the skin
What is the main cause of allergic contact dermatitis?
Contact with sensitizing substances or antigens
Which of the following is NOT a common substance that can cause allergic contact dermatitis?
Vaccines
In allergic contact dermatitis, haptens can complex with skin proteins leading to:
Skin irritation
Which of the following groups of people are more likely to experience anergy in the context of allergic contact dermatitis?
Individuals with immunosuppressive illnesses
Which of the following is NOT a common plant that can cause allergic contact dermatitis?
Hemlock
What type of molecules are many substances that cause allergic contact dermatitis?
Haptens that complex with skin proteins
Test your knowledge on the immunological features and clinical manifestations of allergic contact dermatitis. Learn about the internalization of the complex by APC in the skin (Langerhans cells) and the activation of sensitized Tdth cells. Understand the T-cell mediated eczematous disease characterized by a delayed eczematous response to the application of antigens.
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