Alcoholic Hepatitis Treatment Options
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Questions and Answers

Which of the following is a cause of cirrhosis mentioned in the text?

  • Lung cancer
  • Cystic fibrosis (correct)
  • Diabetes mellitus
  • Rheumatoid arthritis
  • What is the main factor responsible for the development of fibrosis in cirrhosis?

  • Decreased blood flow
  • Autoimmune response
  • Excessive alcohol consumption
  • Activation of hepatic stellate cells (correct)
  • Which condition can lead to reversal of fibrosis in cirrhosis?

  • Autoimmune hepatitis
  • Hemochromatosis (correct)
  • Chronic hepatitis B
  • Primary sclerosing cholangitis
  • What is the result of the development of fibrosis in cirrhosis?

    <p>Formation of regenerative nodules</p> Signup and view all the answers

    What is the relationship between the severity of liver disease and clinical features of cirrhosis?

    <p>They are directly proportional</p> Signup and view all the answers

    Which of the following is NOT a complication of decompensated cirrhosis?

    <p>Jaundice</p> Signup and view all the answers

    What is the most common cause of cirrhosis-related deaths in the United States?

    <p>Alcohol-associated cirrhosis</p> Signup and view all the answers

    Which enzyme system is responsible for the metabolism of alcohol in the liver?

    <p>All of the above</p> Signup and view all the answers

    What is the main site of ethanol absorption in the body?

    <p>Small intestine</p> Signup and view all the answers

    Which of the following is NOT a type of chronic liver disease caused by excessive alcohol use?

    <p>Hemochromatosis</p> Signup and view all the answers

    Which therapy has shown modest evidence of survival benefit in alcoholic hepatitis if the DF is >32?

    <p>Intravenous N-acetylcysteine plus glucocorticoids</p> Signup and view all the answers

    Which therapy is NOT recommended for alcoholic hepatitis?

    <p>Colchicine</p> Signup and view all the answers

    What is recommended to achieve better survival in alcoholic hepatitis?

    <p>Achieving better caloric intake</p> Signup and view all the answers

    In highly selected patients with good social support structure who fail other treatments for alcoholic hepatitis, what can be an effective treatment?

    <p>Early liver transplant</p> Signup and view all the answers

    Which virus is a noncytopathic virus that causes liver damage through immune-mediated mechanisms?

    <p>Hepatitis C virus (HCV)</p> Signup and view all the answers

    Which of the following is NOT a clinical feature of alcohol-associated liver disease?

    <p>Hemolytic anemia</p> Signup and view all the answers

    What is the primary cause of liver contraction and shrinkage in alcohol-associated liver disease?

    <p>Hepatocyte loss</p> Signup and view all the answers

    What is the ratio of AST to ALT levels typically seen in patients with alcohol-associated liver disease?

    <p>2:1</p> Signup and view all the answers

    When is liver biopsy generally performed in the diagnosis of alcohol-associated liver disease?

    <p>When there is suspicion of an alternative diagnosis</p> Signup and view all the answers

    What is the formula to calculate the Discriminant Function (DF) in severe alcoholic hepatitis?

    <p>Serum total bilirubin plus the difference in prothrombin time multiplied by 4.6</p> Signup and view all the answers

    Which antiviral therapy is preferred for treating chronic hepatitis B due to its reduced risk of viral resistance?

    <p>Telbivudine</p> Signup and view all the answers

    Which therapy has revolutionized the treatment of hepatitis C in recent years, with a high success rate, good tolerability, and short duration?

    <p>Direct-acting antiviral protocols</p> Signup and view all the answers

    Which autoimmune markers are typically positive in patients with autoimmune hepatitis (AIH) presenting with established cirrhosis?

    <p>Both ASMA and ANA</p> Signup and view all the answers

    Which chronic cholestatic syndrome is clinically distinguished from other syndromes by antibody testing, cholangiographic findings, and clinical presentation?

    <p>Primary biliary cholangitis (PBC)</p> Signup and view all the answers

    Which histopathologic features are shared by primary biliary cholangitis (PBC), autoimmune cholangitis (AIC), primary sclerosing cholangitis (PSC), and idiopathic adulthood ductopenia?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is true about primary biliary cholangitis (PBC)?

    <p>Liver transplantation is the first-line treatment for PBC.</p> Signup and view all the answers

    What is the first-line treatment for primary biliary cholangitis (PBC)?

    <p>Ursodeoxycholic acid (UDCA)</p> Signup and view all the answers

    What is the significance of antimitochondrial antibodies (AMAs) in PBC?

    <p>They are useful markers for making a diagnosis.</p> Signup and view all the answers

    Which of the following is a clinical feature of primary biliary cholangitis (PBC)?

    <p>Jaundice and hepatomegaly</p> Signup and view all the answers

    What are the laboratory findings in primary biliary cholangitis (PBC)?

    <p>Hyperbilirubinemia once cirrhosis has developed</p> Signup and view all the answers

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