30 Questions
Which of the following is a cause of cirrhosis mentioned in the text?
Cystic fibrosis
What is the main factor responsible for the development of fibrosis in cirrhosis?
Activation of hepatic stellate cells
Which condition can lead to reversal of fibrosis in cirrhosis?
Hemochromatosis
What is the result of the development of fibrosis in cirrhosis?
Formation of regenerative nodules
What is the relationship between the severity of liver disease and clinical features of cirrhosis?
They are directly proportional
Which of the following is NOT a complication of decompensated cirrhosis?
Jaundice
What is the most common cause of cirrhosis-related deaths in the United States?
Alcohol-associated cirrhosis
Which enzyme system is responsible for the metabolism of alcohol in the liver?
All of the above
What is the main site of ethanol absorption in the body?
Small intestine
Which of the following is NOT a type of chronic liver disease caused by excessive alcohol use?
Hemochromatosis
Which therapy has shown modest evidence of survival benefit in alcoholic hepatitis if the DF is >32?
Intravenous N-acetylcysteine plus glucocorticoids
Which therapy is NOT recommended for alcoholic hepatitis?
Colchicine
What is recommended to achieve better survival in alcoholic hepatitis?
Achieving better caloric intake
In highly selected patients with good social support structure who fail other treatments for alcoholic hepatitis, what can be an effective treatment?
Early liver transplant
Which virus is a noncytopathic virus that causes liver damage through immune-mediated mechanisms?
Hepatitis C virus (HCV)
Which of the following is NOT a clinical feature of alcohol-associated liver disease?
Hemolytic anemia
What is the primary cause of liver contraction and shrinkage in alcohol-associated liver disease?
Hepatocyte loss
What is the ratio of AST to ALT levels typically seen in patients with alcohol-associated liver disease?
2:1
When is liver biopsy generally performed in the diagnosis of alcohol-associated liver disease?
When there is suspicion of an alternative diagnosis
What is the formula to calculate the Discriminant Function (DF) in severe alcoholic hepatitis?
Serum total bilirubin plus the difference in prothrombin time multiplied by 4.6
Which antiviral therapy is preferred for treating chronic hepatitis B due to its reduced risk of viral resistance?
Telbivudine
Which therapy has revolutionized the treatment of hepatitis C in recent years, with a high success rate, good tolerability, and short duration?
Direct-acting antiviral protocols
Which autoimmune markers are typically positive in patients with autoimmune hepatitis (AIH) presenting with established cirrhosis?
Both ASMA and ANA
Which chronic cholestatic syndrome is clinically distinguished from other syndromes by antibody testing, cholangiographic findings, and clinical presentation?
Primary biliary cholangitis (PBC)
Which histopathologic features are shared by primary biliary cholangitis (PBC), autoimmune cholangitis (AIC), primary sclerosing cholangitis (PSC), and idiopathic adulthood ductopenia?
All of the above
Which of the following is true about primary biliary cholangitis (PBC)?
Liver transplantation is the first-line treatment for PBC.
What is the first-line treatment for primary biliary cholangitis (PBC)?
Ursodeoxycholic acid (UDCA)
What is the significance of antimitochondrial antibodies (AMAs) in PBC?
They are useful markers for making a diagnosis.
Which of the following is a clinical feature of primary biliary cholangitis (PBC)?
Jaundice and hepatomegaly
What are the laboratory findings in primary biliary cholangitis (PBC)?
Hyperbilirubinemia once cirrhosis has developed
Quiz: Treatment options for alcoholic hepatitis Test your knowledge on the various treatment options available for alcoholic hepatitis. Explore the evidence behind intravenous N-acetylcysteine plus glucocorticoids, oral pentoxifylline, TNF-α inhibitors, anabolic steroids, and more. Discover which therapies have shown potential for survival benefit in patients with a DF >3
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