Affinity Maturation
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Questions and Answers

Which process is responsible for the increase in antibody affinity after prolonged exposure to an antigen?

  • Isotype switching
  • Germinal center formation
  • Affinity maturation (correct)
  • Somatic hypermutation
  • Which type of antigens does affinity maturation occur in response to?

  • Protein antigens (correct)
  • Carbohydrate antigens
  • Lipid antigens
  • DNA antigens
  • Which cells are critical in the process of affinity maturation?

  • Helper T cells (correct)
  • Plasma cells
  • B cells
  • T cells
  • Which of the following is true about somatic hypermutation in germinal center B cells?

    <p>Somatic hypermutation results in the introduction of nucleotides other than the original mutated cytosine.</p> Signup and view all the answers

    Which of the following is true about the frequency of Ig gene mutations compared to other genes?

    <p>The frequency of Ig gene mutations is higher than the mutation rate in most other genes.</p> Signup and view all the answers

    What happens to germinal center B cells that do not undergo somatic hypermutation?

    <p>They undergo apoptosis.</p> Signup and view all the answers

    What is the role of follicular dendritic cells (FDCs) in the selection of B cells in germinal centers?

    <p>FDCs display antigens and select B cells that recognize the antigen to survive.</p> Signup and view all the answers

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