7 Questions
Which process is responsible for the increase in antibody affinity after prolonged exposure to an antigen?
Affinity maturation
Which type of antigens does affinity maturation occur in response to?
Protein antigens
Which cells are critical in the process of affinity maturation?
Helper T cells
Which of the following is true about somatic hypermutation in germinal center B cells?
Somatic hypermutation results in the introduction of nucleotides other than the original mutated cytosine.
Which of the following is true about the frequency of Ig gene mutations compared to other genes?
The frequency of Ig gene mutations is higher than the mutation rate in most other genes.
What happens to germinal center B cells that do not undergo somatic hypermutation?
They undergo apoptosis.
What is the role of follicular dendritic cells (FDCs) in the selection of B cells in germinal centers?
FDCs display antigens and select B cells that recognize the antigen to survive.
Test your knowledge on affinity maturation and its role in increasing antibody affinity. Learn about the process, its impact on antibody binding, and the role of point mutations.
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