Affective Disorders Treatment: Antidepressants
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Questions and Answers

What is the therapeutic index of lithium?

  • Narrow (correct)
  • Moderate
  • Wide
  • Unknown

What is the mechanism of action of pregabalin in prophylaxis of manic depressive psychoses?

  • Enhancement of GABA activity
  • Inhibition of sodium channels
  • Inhibition of downstream signal transduction cascade
  • Blockade of calcium channels, which prevents release of glutamate (correct)

What is the recommended time for monitoring lithium levels after initiating treatment or changing the dose?

  • 7 days after initiating treatment or changing the dose (correct)
  • 1 month after initiating treatment
  • 2-3 days after initiating treatment
  • 12 hours after the last dose

What is the half-life of lithium?

<p>7-20 hours (A)</p> Signup and view all the answers

What is a common side effect of lithium therapy?

<p>Metallic taste in mouth (D)</p> Signup and view all the answers

What is the dose of sodium valproate?

<p>20 mg/kg body weight (D)</p> Signup and view all the answers

What is the indication for sodium valproate?

<p>Treatment of acute manic phase of bipolar affective disorder (A)</p> Signup and view all the answers

What is the laboratory monitoring required for lithium therapy?

<p>Lithium levels, thyroid function tests, and renal function tests (C)</p> Signup and view all the answers

What is the benefit of combining lithium with other mood stabilizers?

<p>Improved efficacy in treatment-resistant cases (B)</p> Signup and view all the answers

What is a rare but serious side effect of lithium therapy?

<p>Nephrogenic diabetes insipidus (D)</p> Signup and view all the answers

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