10 Questions
What is the therapeutic index of lithium?
Narrow
What is the mechanism of action of pregabalin in prophylaxis of manic depressive psychoses?
Blockade of calcium channels, which prevents release of glutamate
What is the recommended time for monitoring lithium levels after initiating treatment or changing the dose?
7 days after initiating treatment or changing the dose
What is the half-life of lithium?
7-20 hours
What is a common side effect of lithium therapy?
Metallic taste in mouth
What is the dose of sodium valproate?
20 mg/kg body weight
What is the indication for sodium valproate?
Treatment of acute manic phase of bipolar affective disorder
What is the laboratory monitoring required for lithium therapy?
Lithium levels, thyroid function tests, and renal function tests
What is the benefit of combining lithium with other mood stabilizers?
Improved efficacy in treatment-resistant cases
What is a rare but serious side effect of lithium therapy?
Nephrogenic diabetes insipidus
Learn about the drugs used to treat affective disorders, including depression, and the monoamine hypothesis. Understand how antidepressants work to elevate neurotransmitter levels. Test your knowledge of selective serotonin reuptake inhibitors, SNRI, and tricyclic antidepressants.
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