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Affective Disorders Treatment: Antidepressants

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Affective Disorders Treatment: Antidepressants

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Questions and Answers

What is the therapeutic index of lithium?

Narrow (correct)

Moderate

Wide

Unknown

What is the mechanism of action of pregabalin in prophylaxis of manic depressive psychoses?

Enhancement of GABA activity

Inhibition of sodium channels

Inhibition of downstream signal transduction cascade

Blockade of calcium channels, which prevents release of glutamate (correct)

What is the recommended time for monitoring lithium levels after initiating treatment or changing the dose?

7 days after initiating treatment or changing the dose (correct)

1 month after initiating treatment

2-3 days after initiating treatment

12 hours after the last dose

What is the half-life of lithium?

7-20 hours (A) Signup and view all the answers

What is a common side effect of lithium therapy?

Metallic taste in mouth (D) Signup and view all the answers

What is the dose of sodium valproate?

20 mg/kg body weight (D) Signup and view all the answers

What is the indication for sodium valproate?

Treatment of acute manic phase of bipolar affective disorder (A) Signup and view all the answers

What is the laboratory monitoring required for lithium therapy?

Lithium levels, thyroid function tests, and renal function tests (C) Signup and view all the answers

What is the benefit of combining lithium with other mood stabilizers?

Improved efficacy in treatment-resistant cases (B) Signup and view all the answers

What is a rare but serious side effect of lithium therapy?

Nephrogenic diabetes insipidus (D) Signup and view all the answers