23 Questions
Which type of receptor is coupled to activation of adenylyl cyclase?
β-adrenergic receptors
What enzyme is activated by DAG binding?
Protein kinase C
What are the products of PIP2 hydrolysis by PLC?
Inositol trisphosphate (IP3)
What binds to receptors on the surface of the endoplasmic reticulum, leading to the release of Ca2+ ions?
IP3
What subunits of phosphorylase kinase interact with Ca2+ ions and cause its activation?
Calmodulin subunits
What is the function of protein kinase C (PKC)?
Phosphorylation of glycogen synthase
Which G-proteins are α-adrenergic receptors coupled through?
Gαs
What is the role of Ca2+ ions in conjunction with DAG?
Activate PKC
What is the function of inositol trisphosphate (IP3)?
Bind to receptors on the surface of the endoplasmic reticulum
What enzyme is phosphorylated by PKC?
Glycogen synthase
What is the function of phospholipase C (PLC)?
Hydrolysis of membrane phosphatidylinositol 4,5-bisphosphate (PIP2)
Which type of receptor is coupled to activation of adenylyl cyclase?
β-adrenergic receptors
What enzyme is activated by DAG binding?
Protein kinase C
What is the product of PIP2 hydrolysis by PLC?
Inositol trisphosphate (IP3)
What binds to receptors on the surface of the endoplasmic reticulum, leading to the release of Ca2+ ions?
IP3
What subunits of phosphorylase kinase are activated by Ca2+ ions?
Calmodulin subunits
What is the function of protein kinase C (PKC)?
Phosphorylation of glycogen synthase
Which G-proteins are α-adrenergic receptors coupled through?
Gαq/11
What is the role of Ca2+ ions in conjunction with DAG?
Activate PKC
What is the function of inositol trisphosphate (IP3)?
Bind to receptors on the surface of the endoplasmic reticulum
What is the product of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by PLC?
Diacylglycerol (DAG)
What enzyme is phosphorylated by PKC?
Glycogen synthase
What is the function of phospholipase C (PLC)?
Hydrolysis of membrane phosphatidylinositol 4,5-bisphosphate (PIP2)
Test your knowledge on the differences between β-adrenergic and α-adrenergic receptors in this quiz. Brush up on the mechanisms of G-protein coupling, adenylyl cyclase activation, and phospholipase C activation. Explore the effects of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and the resulting products, inositol trisphosphate (IP3) and diacylglycerol. Challenge
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