24 Questions
Which enzyme is activated by DAG in α-adrenergic receptor signaling?
Protein kinase C
What are the products of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis in α-adrenergic receptor signaling?
Inositol trisphosphate (IP3) and diacylglycerol (DAG)
What is the role of inositol trisphosphate (IP3) in α-adrenergic receptor signaling?
It binds to receptors on the surface of the endoplasmic reticulum leading to release of Ca2+ ions
What is the role of Ca2+ ions in α-adrenergic receptor signaling?
They interact with the calmodulin subunits of phosphorylase kinase resulting in its activation
Which type of G-protein is involved in α-adrenergic receptor signaling?
Gq
What is the endoplasmic reticulum's role in α-adrenergic receptor signaling?
It binds to inositol trisphosphate (IP3)
What is the role of diacylglycerol (DAG) in α-adrenergic receptor signaling?
It activates protein kinase C (PKC)
Which enzyme is phosphorylated by protein kinase C (PKC) in α-adrenergic receptor signaling?
Glycogen synthase
What is the product of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis in α-adrenergic receptor signaling?
Diacylglycerol (DAG)
What is the role of calmodulin in α-adrenergic receptor signaling?
It interacts with the calmodulin subunits of phosphorylase kinase resulting in its activation
What is the role of phosphorylase kinase in α-adrenergic receptor signaling?
It interacts with the calmodulin subunits of phosphorylase kinase resulting in its activation
What is the role of G-proteins in α-adrenergic receptor signaling?
They activate phospholipase C
Which of the following is true regarding β-adrenergic receptors?
They are coupled to activation of adenylyl cyclase
What is the main enzyme activated by DAG?
Protein kinase C
What is the product of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis?
Inositol trisphosphate (IP3)
What is the main function of Ca2+ ions in the α-adrenergic receptor pathway?
To activate protein kinase C
What is the main function of IP3 in the α-adrenergic receptor pathway?
To bind to receptors on the surface of the endoplasmic reticulum
What is the main function of DAG in the α-adrenergic receptor pathway?
To activate protein kinase C
What is the main function of phospholipase C in the α-adrenergic receptor pathway?
To hydrolyze PIP2
Which of the following is true regarding α-adrenergic receptors?
They are coupled to activation of phospholipase C
What is the function of Ca2+ ions in the phosphorylase kinase pathway?
To activate phosphorylase kinase
What is the function of phosphorylase kinase in the α-adrenergic receptor pathway?
To activate glycogen synthase
What is the function of glycogen synthase in the α-adrenergic receptor pathway?
To synthesize glycogen
What is the function of PKC in the α-adrenergic receptor pathway?
To hydrolyze PIP2
Test your knowledge of β-adrenergic and α-adrenergic receptors in this quiz! Learn about the differences between these two receptor types and their coupling mechanisms, including the activation of adenylyl cyclase and phospholipase C. Discover the effects of increased hydrolysis of membrane phosphatidylinositol 4,5-bisphosphate and the products of inositol trisphosphate and diacylglycerol. Perfect for students of pharmacology or
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